MPTPParkinson's DiseaseNeuronsBrainAdministration of L-3,4-dihydroxyphenylalanineNeuroscience2020LesionMethamphetamineLevodopa10.1007ProteinsRats2019AgonistProtectiveSynapticNeurodegenerationMetabolicMDMAParkinson DiseaseMiceDiabetesDyskinesiaCompoundsDepartmentProteinDoseYearsSubsequentDeficitsSignificantly reducedIonsArticleGenesPathogenicSymptomsPatientsJournalResearchRegulatorFunctional
MPTP19
- In animal models of Parkinson's disease (PD), 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is one of the most widely used agents that damages the nigrostriatal dopaminergic pathway. (ewha.ac.kr)
- Here, we show that drinking H 2 -containing water significantly reduced the loss of dopaminergic neurons in PD model mice using both acute and chronic administration of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). (elsevierpure.com)
- MPTP-induced accumulation of cellular 8-oxoguanine (8-oxoG), a marker of DNA damage, and 4-hydroxynonenal (4-HNE), a marker of lipid peroxidation were significantly decreased in the nigro-striatal dopaminergic pathway in mice drinking H 2 -containing water, whereas production of superoxide (O 2 · - ) detected by intravascular injection of dihydroethidium (DHE) was not reduced significantly. (elsevierpure.com)
- 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) disrupts social memory/recognition processes in the male mouse. (omeka.net)
- In particular, the noradrenergic system and its potential involvement with memory/recognition processes in the CD-1 mouse appears to be very sensitive to the neurotoxic effects of MPTP. (omeka.net)
- MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) is an organic compound. (wikipedia.org)
- Once inside the brain, MPTP is metabolized into the toxic cation 1-methyl-4-phenylpyridinium (MPP+) by the enzyme monoamine oxidase B (MAO-B) of glial cells, specifically astrocytes. (wikipedia.org)
- In 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated, L-DOPA-primedcommonmarmosets,MDMAtransiently relieved motor disability but over a period of 60 min worsened motor symptoms. (erowid.org)
- 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) causes nigrostriatal dopaminergic neurotoxicity and behavioral impairment in rodents. (researchgate.net)
- Moreover, in the 1-methyl-4-phenyl-1,2,4,6-tetrahydropyridine (MPTP) mouse model, dopamine deficiency caused increased phosphorylation of both Tyr15-Cdk5 and Thr75-DARPP-32 in the striatum, which could be attenuated by administration of L-3,4-dihydroxyphenylalanine and imatinib (STI-571), a selective c-Abl inhibitor. (frontiersin.org)
- The effect of L-3,4-dihydroxyphenylalanine (L-DOPA) on dopamine receptor gene expression in the brain of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-lesioned monkeys was investigated using in situ hybridization histochemistry with measures of changes in relative absorbance. (aspetjournals.org)
- hypothesized that their patient had parkinsonism as a result of a delayed neurotoxic effect of 3,4-methylenedioxymethamphetamine (MDMA) on his basal ganglia and noted that his condition most closely resembled nigrostriatal damage induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). (erowid.org)
- The partial elucidation of the processes underlie the selective action of neurotoxic substances such as 6-hydroxydopamine (6-OHDA) or 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), has however revealed possible molecular mechanisms that give rise to neuronal death. (nih.gov)
- Attempts to synthesise pethidine have resulted in the accidental production of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), a compound which is metabolised in the brain by the monoamine oxidase system to a toxic intermediate (MPP+) which selectively destroys the sustantia nigra, resulting in the rapid onset of severe Parkinsonian symptoms. (erowid.org)
- Parkinsonin taudin eläinmallien, kuten 6-OHDA- (6-hydroksidopamiini) ja MPTP-mallin (1-metyyli-4-fenyyli-1,2,3,6-tetrahydropyridiini) mekanismeissa on samankaltaisuuksia. (helsinki.fi)
- The authors also showed that the presence of β-synuclein increased resistance to subchronic administration of the Parkinson's disease-inducing prodrug 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, or MPTP, in dopaminergic neurons of the substantia nigra pars compacta when one or both of the other synucleins are absent. (asbmb.org)
- Effects of (R)-ketamine, (S)-ketamine, and their metabolites on MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine)-induced reduction of dopamine transporter (DAT) and tyrosine hydroxylase (TH) in the mouse striatum and substantia nigra (SNr) were examined. (unboundmedicine.com)
- Here we describe the use of a neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), which produces a nigrostriatal lesion to elucidate the distinct contributions of LOX isozymes to neurodegeneration related to PD. (sri.com)
- We also studied genetic differences among 10 BXD recombinant inbred mouse strains to MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine), a proneurotoxicant (the active agent is the metabolite, MPP+ produced in astrocytes) used to model the pathophysiology of Parkinson's disease. (cdc.gov)
Parkinson's Disease2
- Parkinson's disease (PD) is a progressive neurodegenerative disorder featured by dopaminergic neuronal loss in the substantia nigra pars compacta (SNc) and accumulation of intracellular α-synuclein (α-syn)-containing Lewy bodies 1 . (nature.com)
- We investigated the influence of gender and oestrogen status on: (1) age at onset, (2) presenting symptom, (3) severity and progression of motor symptoms (Unified Parkinson's Disease Rating Scale III (UPDRS-III) scores) and (4) amount and progression of nigrostriatal degeneration ([ 123 I]FP-CIT single photon emission computed tomography measurements). (bmj.com)
Neurons4
- PSAP is decreased, and α-syn is increased in iPSC-derived DA neurons of sporadic PD patients 6 . (nature.com)
- Based on these observations, the dopamine neu- from dopamine neurons implanted into the brain pa- rons used for transplantation in these experiments renchyma with the goal of reinnervating the dener- were neuroblasts obtained from mid-trimester rat vated striatum.8,9 Rats with unilateral, 6-hydroxydo- fetuses. (lu.se)
- VM), showed that the recovery of motor functions induced implanted either (1) as a solid piece in the lateral ven- by the grafted fetal dopamine neurons was well cor- tricle6 or a cortical cavity8 adjacent to the denervated related with the extent of graft-derived reinnervation caudate-putamen, or (2) as a crude cell suspension of the host caudate-putamen. (lu.se)
- The 2 major neuropathologic findings in Parkinson disease are loss of pigmented dopaminergic neurons of the substantia nigra pars compacta and the presence of Lewy bodies and Lewy neurites. (medscape.com)
Brain7
- It has been shown that molecular hydrogen (H 2 ) acts as a therapeutic antioxidant and suppresses brain injury by buffering the effects of oxidative stress. (elsevierpure.com)
- Our results indicated that low concentration of H 2 in drinking water can reduce oxidative stress in the brain. (elsevierpure.com)
- Dopamine (DA) replacement therapies and deep brain stimulation relieve motor symptoms but do not slow down the progressive neurodegeneration 2 . (nature.com)
- For this purpose, WIN 55,212-2 was injected in pregnant wistar rats from gestation day 5 to 20 and a detailed analysis of the levels of the neurotrophin brain-derived neurotrophic factor (BDNF) as well as of the signaling molecules extracellular signal-regulated kinase (ERK)1/2 and alpha-calcium/calmodulin-dependent protein kinase II (alpha-CaMKII) was carried out in adult offspring. (researchgate.net)
- 1 And while the H1N1 flu strain couldn't cross the blood-brain barrier, it still caused central nervous system immune cells called microglia to flow into the substantia nigra and the hippocampus, causing inflammation and cell death in the area. (the-scientist.com)
- Brain Structure and Function, 1-19. (mbfbioscience.com)
- To assess inflammatory markers, which may demonstrate LOX isozyme-selective sensitivity, glial fibrillary acidic protein (GFAP) and Iba-1 immunohistochemistry are performed on brain sections containing substantia nigra, and GFAP Western blot analysis is performed on striatal homogenates. (sri.com)
Administration of L-3,4-dihydroxyphenylalanine1
- Changes of D1 and D2 dopamine receptor mRNA in the brains of monkeys lesioned with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: correction with chronic administration of L-3,4-dihydroxyphenylalanine. (aspetjournals.org)
Neuroscience1
- Journal of Neuroscience Research , 83 (4), pp. 680-693. (ntu.ac.uk)
20202
- 2020;237(1):83-92. (unboundmedicine.com)
- En los últimos años he compaginado mi labor investigadora con la actividad docente, y con labores de gestión: Subdirectora del Departamento de Farmacología, Universidad de Navarra (2009-12), Directora del Departamento de Farmacología y Toxicología, Universidad de Navarra (2012-2014) y Vicedecana (2014-2020) y Decana (2020- actualidad) de la Facultad de Farmacia y Nutrición, Universidad de Navarra. (unav.edu)
Lesion1
- In the cerebellar cortex, tenascin-C mRNA in Golgi epithelial cells was down-regulated 3 days after the lesion and returned to control values 80 days after the lesion. (researchgate.net)
Methamphetamine1
- Although most of these compounds are only of historical interest, amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine (MDA), and 3,4-methylenedioxymethamphetamine (MDMA) continue to be used recreationally. (erowid.org)
Levodopa1
10.10071
- 10.1007/978-1-4939-7665-2_13. (us.es)
Proteins3
- In particular, prenatal cannabinoid treatment reduced the phosphorylated levels of ERK1/2 in selected subcellular compartments of hippocampus, frontal and prefrontal cortex, whereas no changes were observed in the total levels of these proteins. (researchgate.net)
- The multifunctional regulator nuclear factor erythroid 2-related factor (Nrf2) is considered not only as a cytoprotective factor regulating the expression of genes coding for anti-oxidant, anti-inflammatory and detoxifying proteins, but it is also a powerful modulator of species longevity. (springer.com)
- The major characteristics of Nrf2 are to some extent mimicked by Nrf2-dependent genes and their proteins including heme oxygenase-1 (HO-1), which besides removing toxic heme, produces biliverdin, iron ions and carbon monoxide. (springer.com)
Rats1
- Furthermore, a robust reduction of total and phospho-alpha-CaMKII was found in the hippocampus of rats prenatally exposed to WIN 55,212-2. (researchgate.net)
20191
- 2019;113:1-9. (intramed.net)
Agonist4
- MDMA similarly alleviated dyskinesia induced by the selective dopamine D2/3 agonist pramipexole. (erowid.org)
- It has recently been demonstrated that prenatal exposure to the cannabinoid receptor 1 agonist (R)-(+)-[2,3-dihydro-5-methyl-3-(4-morpholinyl-methyl)pyrrolo[1,2,3-de]-1,4-benzoxazin-6-yl]-1-naphthalenylmethanone (WIN 55,212-2) produces memory deficit in adulthood, an effect associated with a reduced functionality of the glutamatergic system. (researchgate.net)
- The Effects of NLY01, a Novel Glucagon-Like Peptide-1 Receptor Agonist, on Cuprizone-Induced Demyelination and Remyelination: Challenges and Future Perspectives. (neurotree.org)
- We used (+)-PHNO, a selective D2 agonist, as the only treatment in 6 cynomolgus monkeys made parkinsonian by repeated 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine administration. (cun.es)
Protective2
- This review summarizes our knowledge about Nrf2 and HO-1 across different phyla suggesting their conservative role as stress-protective and anti-aging factors. (springer.com)
- encoded by Nfe2l2 gene) is a transcription factor responsible for the regulation of cellular redox balance and protective antioxidant and phase II detoxification responses in mammals [ 1 , 2 ]. (springer.com)
Synaptic2
- The aim of our study was to identify molecular changes produced by prenatal exposure to WIN 55,212-2 that might contribute to late disruption in synaptic plasticity and cognition. (researchgate.net)
- the donor.4,11 In the case of nerve cells obtained from either delivery of dopamine released from cells the developing central nervous system (CNS), the opti- implanted into the ventricle, adjacent to the stria- mal age was shown to be at, or close to, the cell-cycle tum,6,7 or restoration of synaptic dopamine release exit. (lu.se)
Neurodegeneration3
- Thus, drinking H 2 -containing water may be useful in daily life to prevent or minimize the risk of life style-related oxidative stress and neurodegeneration. (elsevierpure.com)
- On the other hand, the disturbances in the proper HO-1 level are associated with the pathogenesis of some age-dependent disorders, including neurodegeneration, cancer or macular degeneration. (springer.com)
- 3 - 6 In recent years, the involvement of FMOs in neurodegeneration and aging has emerged, 7 but the underlying mechanisms have not been elucidated. (xiahepublishing.com)
Metabolic1
- 2 FMOs are involved in the pathogenic process of trimethylaminuria, atherosclerosis, cardiovascular disease, diabetes, and metabolic disorders. (xiahepublishing.com)
MDMA1
- Ecstasy [3,4-methylenedioxymethamphetamine (MDMA)] was shown to prolong the action of L-3,4-dihydroxyphenylalanine (L-DOPA) while suppressing dyskinesia in a single patient with Parkinson s disease (PD). (erowid.org)
Parkinson Disease2
- Parkinson disease (PD) is one of the most common neurologic disorders, affecting approximately 1% of individuals older than 60 years and causing progressive disability that can be slowed, but not halted, by treatment. (medscape.com)
- Parkinson disease is recognized as one of the most common neurologic disorders, affecting approximately 1% of individuals older than 60 years. (medscape.com)
Mice1
- GM-CSF induces neuroprotective and anti-inflammatory responses in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine intoxicated mice. (mbfbioscience.com)
Diabetes1
- Your doctor may thirst for you to supervisor your blood sugar if you're taking clarithromycin with whole of these medicines for sort 2 diabetes. (janmille.ru)
Dyskinesia2
Compounds1
- Synthetic opioid derivatives, which represent the second major class of 'designer drugs', are derivatives of fentanyl (e.g. alpha-methylfentanyl, 3-methylfentanyl) or pethidine (meperidine) and are extremely potent compounds responsible for numerous overdose deaths. (erowid.org)
Department1
- 1 Department of Clinical Neurochemistry, University Neurological Clinic, University of Würzburg, Federal Republic of Germany. (nih.gov)
Protein2
- Nrf2 consists of six functional Neh domains (Neh1-Neh6), from which, the amino-terminal Neh2 domain controls binding Keap1-the inhibitor protein Kelch-like ECH-associated protein 1, that is responsible for the cytosolic sequestration of Nrf2 under physiological conditions (Fig. 2 a). (springer.com)
- Here, we show that ependyma-derived matricellular protein CCN1 (cellular communication network factor 1) negatively regulates niche capacity and NSC number in the adult ventricular-subventricular zone (V-SVZ). (stanford.edu)
Dose1
- Animals were divided into 3 groups: control group, moderate dose group (Ac MD) and high dose group (Ac HD). (preprints.org)
Years1
- Identical year later he of 47 patients with hip disease using a cementless graduated as MB BS in the University of London, system consisting of a Urist acetabular cup and within 2 more years had successfully negoti- machined to ?t precisely a hip prosthesis was ated the terrifying hurdles of the best years and important, because it demonstrated that the application of ?nal examinations for the treatment of the FRCS (Eng). (janmille.ru)
Subsequent2
- From a clinical point of view, AD has a strong impact on the lifestyle of patients which is characterized by a prodromal phase with a subsequent progressive loss of memory and decline of cognitive functions, leading to the need for continuous medical care [ 2 ]. (ijpsonline.com)
- The primary clinical features of AD are loss of memory and memory impairment at the early stage, subsequent topographical difficulties, loss of attention, confidence and judgment [ 3 ]. (ijpsonline.com)
Deficits2
- In summary, the present data suggest that deficits of BDNF levels and signaling through ERK1/2 and alpha-CaMKII might contribute to cognitive and neuroplastic defects associated with prenatal exposure to cannabinoids. (researchgate.net)
- AD is characterized by the presence of extracellular deposits of insoluble amyloidbeta (β) plaques, Neurofibrillary Tangles (NFT) and cholinergic deficits [ 1 ]. (ijpsonline.com)
Significantly reduced1
- We found that exposure to WIN 55,212-2 significantly reduced BDNF levels in hippocampus and frontal cortex. (researchgate.net)
Ions1
- Metal Ions in Biology, Vol. 4. (uga.edu)
Article2
- PLoS ONE , 13 (1), Article e0189804. (ewha.ac.kr)
- PloS one , 4 (9), Article e7247. (elsevierpure.com)
Genes2
- The discovery of the antioxidant response element (ARE) have led to the conclusion that the battery of genes, including glutamate-cysteine ligase (GCL), thioredoxin reductase 1 (Txnrd1), NAD(P)H-quinone oxidoreductase 1 (NQO1) and heme oxygenase-1 (HMOX1) is regulated through Nrf2 binding to this consensus binding sequence [ 3 ]. (springer.com)
- Nrf2 stabilization and increase in its half-life even to 200 min [ 9 ] allows nuclear translocation and activation of transcription of cytoprotective genes (Fig. 1 ). (springer.com)
Pathogenic1
- and (3) what is the pathogenic role of these abnormalities? (nih.gov)
Symptoms1
- PD patients are inflicted by motor symptoms and numerous non-motor symptoms 2 . (nature.com)
Patients1
- They reported dramatically positive results in 2 patients that received pieces of adrenal medulla placed in At this point the development took an unexpected a premade cavity in the head of the caudate nucleus on 1 and somewhat surprising turn. (lu.se)
Journal1
- In a study recently published in the Journal of Biological Chemistry , Charlotte B. Spliid of the University of California, San Diego, and Copenhagen University Hospital, Denmark, and an international teamperformed structural analysis of ofCS and found that both placenta- and tumor-derived ofCS had high N-acetylgalactosamine 4-O-sulfation levels. (asbmb.org)
Research2
- Neurochemical Research , 40 (6), 1283-1293. (elsevierpure.com)
- La estancia postdoctoral que disfruté en el Dementia Research Laboratory (King's College, Londres), me permitió, además de desarrollar mi habilidades técnicas e intelectuales, el ponerme en contacto y comenzar colaboraciones de investigación, que se mantiene a dia de hoy. (unav.edu)
Regulator1
- Zinc-finger E-box binding homeobox 1 (Zeb1) is a key regulator of epithelial-mesenchymal transition and cancer metastasis. (stanford.edu)
Functional1
- To investigate whether tenascin-C and tenascin-R may play important functional roles in the lesioned central nervous system, we have analysed their expression in the olivocerebellar system of the adult rat after 3-acetylpyridine-induced degeneration of nerve cells in the inferior olivary nucleus. (researchgate.net)