1 electrons receptor. Medical search. Frequent questions

Herein, we present five cryo-electron microscopy structures of S1PRs bound to diverse drug agonists and the heterotrimeric Gi protein. (rcsb.org)
Within the TEM field, cryo-electron microscopy (cryo-EM) allows visualization of intact molecules/complexes under near native conditions. (utmb.edu)
Further, the development of cryo-electron microscopy tomographic techniques (cryo-ET) has made it possible to image structurally heterogeneous objects such as cells and organelles to nanometer resolution. (utmb.edu)
Their pioneering work on the use of cryo-electron microscopy to solve high-resolution structures of biomolecules has provided unprecedented insights into the complexity of life. (nature.com)
Single-particle cryo-electron microscopy has enabled the structures of large proteins to be elucidated. (nature.com)
Single-particle cryo-electron microscopy (cryo-EM) has emerged over the last two decades as a technique capable of studying the structure of challenging systems. (nature.com)
The structures of AMPA receptors in complex with auxiliary proteins are resolved by cryo-electron microscopy, and reveal conformational and permeation pathway changes that are associated with activation and desensitization of ionotropic glutamate receptors. (nature.com)
We used cryo-electron microscopy to capture the epithelial calcium channel TRPV6 (transient receptor potential vanilloid subfamily member 6) inactivated by CaM. (columbia.edu)

2018). Deletion of in adult mice impairs basal AMPA receptor transmission and LTP in hippocampal CA1 pyramidal neurons. (tcdb.org)
Chen X, Jia B, Araki Y , Liu B , Ye F, Huganir R , Zhang M. Arc weakens synapses by dispersing AMPA receptors from postsynaptic density via modulating PSD phase separation. (neurotree.org)
Visualizing synaptic plasticity in vivo by large-scale imaging of endogenous AMPA receptors. (neurotree.org)

Insulin receptor substrate (IRS) proteins play essential roles in mediating insulin/IGF signaling by recruiting a series of downstream effectors 23 . (nature.com)
Since these intrinsically disordered regions, which are conformationally dynamic and do not adopt stable secondary or tertiary structures, are often essential for mediating the phase transition of proteins 9 , it is therefore of interest to consider if the C-terminus of IRS-1 is involved in phase separation and to further delineate such implications upon insulin/IGF signaling. (nature.com)
IRS-1 protein binds to several oncogene proteins. (biomedcentral.com)
The insulin receptor substrate (IRS) proteins are a family of cytoplasmic adaptor proteins recognized for their role in insulin signaling. (biomedcentral.com)
Sorting nexins (SNXs) are phox homology (PX) domain-containing proteins thought to regulate endosomal sorting of internalized receptors. (nih.gov)
New insights into the role of sequestosome 1/p62 mutant proteins in the pathogenesis of Paget's disease of bone. (msdmanuals.com)
Image analysis of the matched maps identified 7 proteins that were either over- or down-expressed: activated protein kinase c receptor (LACK), alpha tubulin (×2), prostaglandin f2-alpha synthase, protein disulfide isomerase, vesicular transport protein and a hypothetical protein. (who.int)
Our preliminary study using 2D isolates were recovered from liq- new cases throughout the world cu- gel electrophoresis in drug sensitive/ uid nitrogen, and sub-cultured in taneous leishmaniasis (CL) remains resistant strains of L. tropica showed RPMI1640 medium (Gibco/BRL) a serious public health problem in that some proteins were differentially supplemented with 10% fetal bovine numerous countries [1,2]. (who.int)

SARS-CoV-2 S protein binds to the ACE2 receptor at the surface of host cells, initially through the S1 RBD. (abcam.com)

rather it specifically perturbs endosome-to-trans Golgi network (TGN) transport of the cation-independent mannose-6-phosphate receptor (CI-MPR). (nih.gov)

Fast inhibition in the CNS is principally mediated by the neurotransmitter GABA acting on GABA A and GABA C ionotropic receptors ( Macdonald and Olsen, 1994 ). (jneurosci.org)
glutamate receptor, ionotropic, NMDA1. (wikigenes.org)

Given the critical nature of receptor internalization and endosomal signaling for FSHR activity, we assessed whether these compounds exhibit differential abilities to alter receptor endosomal trafficking and signaling within the VEE. (frontiersin.org)
All compounds exhibited a similar requirement for receptor internalization to increase cAMP and proportion of FSHR endosomes with active Gαs, suggesting regulation of cAMP signaling induced by T1 may be altered. (frontiersin.org)
The compounds were studied both in 1 : 1 (v/v) methanol/water and water by UV-visible absorption and steady-state fluorescence spectroscopy. (rsc.org)
Many of the older non-phenoxybenzyl Type 1 compounds ( e.g ., bioallethrin, tetramethrin) are unstable in the environment and this characteristic prevented their use in row crops, but they found wide application for use indoors. (umn.edu)
Compounds in which components share electrons are known as covalent compounds. (parpreceptor.com)

These data suggest that the activation of VMH EphA5 receptors by ephrinA5 may act in concert with β-cell Eph receptor forward signaling to restore glucose homeostasis during acute hypoglycemia via alterations in glutamate/glutamine cycling ( 7 , 8 ). (diabetesjournals.org)

Membrane trafficking of G protein-coupled receptors (GPCRs) tightly orchestrates the signaling from this superfamily of signaling receptors. (frontiersin.org)
The nicotinic acetylcholine receptor controls electrical signalling between nerve and muscle cells by opening and closing a gated, membrane-spanning pore. (proteopedia.org)
This reaction is accomplished by a flux of protons across the membrane as a result of electron transfer. (thermofisher.com)
however, it has recently been identified on the plasma membrane of several cell types including hepatocytes where it functions as the HDL receptor, on endothelial cells where it may act as the angiostatin receptor, and on the surface of cancer cells. (thermofisher.com)
BTK, a TEC-family tyrosine kinase activated by the B-cell antigen receptor, contains a variety of regulatory domains and it is subject to complex regulation by membrane phospholipids, protein ligands, phosphorylation, and dimerization. (elifesciences.org)

To assess tissue redox status, electron paramagnetic resonance and NOx measurements were performed, while inflammatory biomarkers were measured via multiplex assay. (cdc.gov)
Oxidant generation was assessed by electron paramagnetic resonance spectroscopy (EPR) and via flow cytometry. (cdc.gov)

a few axons penetrate to lamina V. At the ultrastructural level, 5-HT 1D receptors in the spinal cord dorsal horn are localized exclusively within dense core vesicles of synaptic terminals. (jneurosci.org)
Immunohistochemistry localized the ρ1 subunit to neurons at light and electron microscopic levels, where it was detected at synaptic junctions. (jneurosci.org)
Within the central nervous system, Eph receptors and their ligands, the ephrins, play a key role in cell-to-cell communication as well as in synaptic structure and function. (diabetesjournals.org)

Fast inhibition in the nervous system is commonly mediated by GABA A receptors comprised of 2α/2β/1γ subunits. (jneurosci.org)
Overexpression of IRS-1 resulted in inhibition of basal autophagy, and reduced oxidative stress-induced autophagy and cell death. (biomedcentral.com)
ROS decreased the mammalian target of rapamycin (mTOR)/p70 ribosomal protein S6 kinase signaling, while overexpression of IRS-1 attenuated this inhibition. (biomedcentral.com)
ROS-mediated autophagy may occur via inhibition of IRS-1/phosphatidylinositol 3-kinase/mTOR signaling. (biomedcentral.com)
One effort focuses on an unusual cholinergic receptor that mediates efferent inhibition of hair cells, driving discovery of the molecular mechanisms, and offering a target for protection against acoustic trauma. (hopkinsmedicine.org)

SNX1 is associated with early endosomes, from where it has been proposed to regulate the degradation of internalized epidermal growth factor (EGF) receptors through modulating endosomal-to-lysosomal sorting. (nih.gov)
Since epidermal growth factor receptor (EGFR)-tyrosine kinase inhibitors, including gefitinib (GEF) have been reported to induce the apoptosis of several cancer cell lines, in the present study, we examined whether the cytotoxic effects of GEF are further enhanced under amino acid starvation (AAS) culture conditions. (spandidos-publications.com)
Electron Murine epidermal Langerhans cells (LC) have been demonstrated to stimulate a vigorous T cell response to Leishmania major, a cause of human cutaneous leishmaniasis. (uni-wuerzburg.de)

In contrast, GABA C receptors containing onlyρ subunits (ρ1-ρ3) have been predominantly detected in the retina. (jneurosci.org)
We therefore tested the hypothesis that GABA A and GABA C subunits formed a heteromeric receptor. (jneurosci.org)
Immunohistochemistry indicated that ρ1 and α1 subunits were colocalized at light and electron microscopic levels. (jneurosci.org)
Taken together these separate lines of evidence suggest that the effects of GABA in central neurons can be mediated by heteromeric complexes of GABA A and GABA C receptor subunits. (jneurosci.org)
One explanation could be that ρ subunits assemble with subunits from other receptor subfamilies, but this hypothesis is contentious. (jneurosci.org)
This protein contains two subunits: the S1 subunit that contains the receptor-binding domain (RBD) and N-terminal domain (NTD), and a second S2 subunit that mediates the fusion of the viral and host cell membranes 4 . (abcam.com)

Electron microscopy demonstrated a poorly differentiated mesenchymal tumor with a multifocal giant cell component and evidence of neurosecretory-granules. (hindawi.com)
Electron microscopy demonstrated that the CAL 27 cells treated with GEF under AAS culture conditions exhibited swelling of the cytosol and organelles with an increased number of autophagosomes and autolysosomes, but without chromatin condensation and nuclear fragmentation. (spandidos-publications.com)

This group also found that while both receptor subtypes were seen in the membranes and cytoplasm of cell bodies, the β 2 receptor subtype, but not the β 1 , was localized to the nucleus. (frontiersin.org)
The sigma-2 receptor (σR2) subtype has been identified pharmacologically [ 7 ], but has yet to be cloned. (molvis.org)

The sigma-1 receptor (σR1), a ligand-operated chaperone, has been inferred to be neuroprotective in previous studies using σR1 ligands. (molvis.org)

To understand better the cellular mechanisms of NE and its adrenergic receptors in the LA, we used antibodies directed against dopamine beta-hydroxylase (DβH), the synthetic enzyme for NE, or against two different isoforms of the beta-adrenergic receptors (βARs), one that predominately recognizes neurons (βAR 248) and the other astrocytes (βAR 404), to characterize the microenvironments of DβH and βAR. (frontiersin.org)

Neuropeptides typically bind to G protein-coupled receptors (GPCRs) to modulate neural activity and other tissues like the gut, muscles, and heart. (wikipedia.org)
Most neuropeptides act on G-protein coupled receptors (GPCRs). (wikipedia.org)

Our structural and functional assays demonstrate the different binding modes of chemically distinct agonists of S1PRs, reveal the mechanical switch that activates these receptors, and provide a framework for understanding ligand selectivity and G protein coupling. (rcsb.org)
Agonists at serotonin 1D (5-HT 1D ) receptors relieve migraine headache but are not clinically used as general analgesics. (jneurosci.org)
The introduction of agonists that activate serotonin 1B (5-HT 1B ) and 5-HT 1D receptors (the "triptans") has revolutionized treatment for many migraineurs. (jneurosci.org)
Responses to GABA C agonists were also enhanced by the GABA A receptor modulator pentobarbitone (300 μM). (jneurosci.org)
Electrophysiology revealed that responses to GABA C receptor agonists were enhanced by the GABA A receptor modulator zolpidem (500 n m ), which acts on the α1 subunit when the γ2 subunit is also present. (jneurosci.org)

Adenovirus (types 1, 2, 3, and 5) commonly causing respiratory tract infections increased the binding of. (lu.se)
Adenovirus (types 1, 2, 3, and 5) commonly causing respiratory tract infections increased the binding of adherent S. pneumoniae strains to the cells. (lu.se)
This suggested that adenovirus infection upregulated receptors for S. pneumoniae. (lu.se)

Our finding, that 5-HT 1D receptors are distributed in nociceptors throughout the body, raises the possibility that triptans can regulate not only headache-associated pain but also nociceptive responses in extracranial tissues. (jneurosci.org)
another ER chaperone), and becomes available to regulate inositol trisphosphate (IP3) receptor-mediated Ca 2+ release to maintain mitochondrial Ca 2+ homeostasis. (molvis.org)
In turn, receptor signaling is known to drive or regulate GPCR trafficking. (frontiersin.org)

These changes may be mediated by the peroxisome proliferator-activated receptor γ coactivator-1 (PGC1) pathway. (diabetesjournals.org)
Several other mutations associated with Paget disease have been identified, many affecting the RANK (receptor activator of nuclear factor kappa-B) signaling pathway that is critical for osteoclast generation and activity. (msdmanuals.com)

The main IRS-1 downstream signaling pathways include type I phosphatidylinositol 3-kinase (PI3K)/Akt (PKB: protein kinase B), mammalian target of rapamycin (mTOR), and mitogen activated protein kinase (MAPK)/extracellular signal-regulated kinase (ERK). (biomedcentral.com)
The activation of both MAPK and PI3K signaling pathways has been implicated in the stimulation of proliferation by IRS-1 [ 11 ]. (biomedcentral.com)
The two conductance states are governed by the S-S bonds reaction with Au which controls the orientation of the protein in the circuit, and via which different electron pathways are created. (rsc.org)

Single-particle electron cryo-microscopy analysis of the mechanotransduction channel NOMPC reveals that it contains a bundle of four helical spring-shaped ankyrin repeat domains that undergo motion, potentially allowing mechanical movement of the cytoskeleton to be coupled to the opening of the channel. (nature.com)
The NS1 hexamer in crystal structures is similar to a solution hexamer visualized by single-particle electron microscopy. (nih.gov)

Freshly isolated LC, but not cultured LC, phagocytosed L. major and the uptake was inhibited by antibodies to the complement receptor type 3. (uni-wuerzburg.de)

2023 , 002 , p. 1-31 2023-002. (lu.se)

The VEE is a heterogeneous compartment containing the Adaptor Protein Phosphotyrosine Interacting with Pleckstrin homology Domain and Leucine Zipper 1 (APPL1) with distinct functions in regulating endosomal Gαs/cAMP signaling and rapid recycling. (frontiersin.org)

The presence of necrostatin-1, an inhibitor of receptor-interacting serine/threonine-protein kinase 1 (RIPK‑1), but not that of Z-VAD-fmk, attenuated the cytotoxic effects of GEF under AAS culture conditions. (spandidos-publications.com)
However, we could not detect any phosphorylation of RIPK-1 and mixed lineage kinase domain like pseudokinase (MLKL), as well as any necrosome formation. (spandidos-publications.com)
We have produced crystals of full-length BTK for the first time but despite efforts to stabilize the autoinhibited state, the diffraction data still reveals only the SH3-SH2-kinase core with no electron density visible for the PHTH-PRR segment. (elifesciences.org)
In addition to the cellular energy sensor AMP kinase, the peroxisome proliferator-activated receptor cofactors PGC1α ( 5 , 6 , 7 ) and possibly PGC1β ( 8 ) activate mitochondrial biogenesis and increase OXPHOS gene expression by increasing the transcription, translation, and activation of the transcription factors necessary for mitochondrial DNA (mtDNA) replication. (diabetesjournals.org)

This was largely due to 2 primary points of contention: (1) Which side of the nerve-muscle junction was the defect in MG (the presynaptic nerve endings or the postsynaptic motor end plate)? (medscape.com)
Here we present an atomic model of the closed pore, obtained by electron microscopy of crystalline postsynaptic membranes. (proteopedia.org)

Differential expression patterns of phospholipase D isoforms 1 and 2 in the mammalian brain and retina. (neurotree.org)

In this study, we examined whether recurrent hypoglycemia alters the capacity of the ephrinA5 ligand to activate VMH EphA5 receptors, and if so, whether these changes could contribute to pathogenesis of defective glucose counterregulation in response to a standard hypoglycemic stimulus. (diabetesjournals.org)
In conclusion, TSP-1 is an important ligand mediating MWCNT-induced microvascular dysfunction, and CD47 is a component of this dysregulation. (cdc.gov)

Under prolonged cellular stresses, the σR1 translocates to the extended ER network, whereby it interacts with and regulates the function of a variety of ion channels, receptors, or kinases. (molvis.org)
Indeed, the increased transmissibility of SARS-CoV-2 compared with SARS-CoV could potentially be explained by an increased number of cellular receptors allowing the virus to penetrate host cells. (abcam.com)

Under AAS culture conditions, the cell killing effect of GEF was synergistically pronounced in the EGFR-expressing cell lines, namely, CAL 27, Detroit 562, A549 and PANC-1 cells compared with those treated with either GEF or AAS alone. (spandidos-publications.com)

Membranes determine the integrity of a cell and what can and cannot pass through via receptor sites and the biochemical processes of the cell via cell signalling (2). (canceractive.com)

1994. Ah receptor in embryonic mouse palate and effects of TCDD on receptor expression. (cdc.gov)

IRS-1 contains no transmembrane domain but an amino-terminal pleckstrin homology (PH) and a phosphotyrosine-binding domain (PTB), followed by a carboxyl-terminal region which is enriched in Ser and Thr residues 28 . (nature.com)
The tripartite TLRs are type I integral transmembrane receptors that are involved in recognition and conveying of pathogens to the immune system. (tcdb.org)

By electron microscopy, βAR 248 was present in neuronal cell bodies, dendritic shafts and spines, and some axon terminals and astrocytes. (frontiersin.org)

Subsequent microscopic examination and immunohistochemical analysis revealed a phosphaturic mesenchymal tumor mixed connective tissue variant (PMTMCT) showing a positive expression of somatostatin receptor 2A (SSTR2A), CD68, and Periostin. (hindawi.com)
Electron microscopic studies revealed the presence of viable amastigotes within Le. (uni-wuerzburg.de)

1994. Polychlorinated biphenyls, 1,1,1-trichloro-2,2 bis(p-chlorophenyl)ethane (p,p'-DDT) and 1,1-dichloro-2,2-bis(p-chlorophenyl)-ethylene (p,p'-DDE) in human plasma related to fish consumption. (cdc.gov)

New colorimetric receptors R1 and R2 with varied positional substitution of a cyano and nitro signaling unit having a hydroxy functionality as the hydrogen bond donor site have been designed, synthesized and characterized by FTIR, 1 H NMR spectroscopy and mass spectrometry. (beilstein-journals.org)
Particle surface chemistry was characterized by X-ray photo electron spectroscopy (XPS) and Fourier-transform infrared spectroscopy (FTIR). (cdc.gov)

Increasing research interest on the selective and sensitive detection of anions has enriched the field of anion receptor chemistry with a wide array of design strategies [15-19] . (beilstein-journals.org)
Pyrethroid chemistry and action are classified as Type 1 or Type 2, depending on the alcohol substituent in the molecule. (umn.edu)

Lung tissue gene/protein response demonstrated distinct patterns that are better predicted by either particle dose/aerosol responses (IL-1, KC, TGF-) or particle reactivity (TSLP, IL13, IL-6). (cdc.gov)

The TEC kinases are the second largest sub-family of non-receptor tyrosine kinases in the human genome after the SRC family [ 1 - 3 ]. (elifesciences.org)

Moreover, tyrosine residues of YXXM motifs, which recruit downstream effectors, also contributed to IRS-1 self-association and LLPS. (nature.com)

Moreover, IRS-1 was found to form high-molecular-mass complexes in different types of cells 30 . (nature.com)
The formation of the receptor-anion complexes has been supported by UV-vis titration studies and confirmed through binding constant calculations. (beilstein-journals.org)

Electrochemical biosensors are normally based on enzymatic catalysis of a reaction that produces or consumes electrons (such enzymes are rightly called redox enzymes). (tek.com)

1991. Effects of polychlorinated biphenyls with Ah receptor affinity on lymphoid development in the thymus and the bursa of Fabricius on chick embryos in ovo and in mouse thymus anlagen in vitro . (cdc.gov)

Neuropeptide receptor affinity is in the nanomolar to micromolar range while neurotransmitter affinity is in the micromolar to millimolar range. (wikipedia.org)

Frequent episodes of acute hypoglycemia represent the principal obstacle to achieving optimal glycemic control during insulin treatment in patients with type 1 diabetes and long-standing type 2 diabetes ( 1 , 2 ). (diabetesjournals.org)
Immunolabeling detected this receptor in cells of both the ganglion cell layer and the photoreceptor cell layer in wild-type retinas. (molvis.org)
The knockdown of L-type amino acid transporter 1 (LAT-1) by siRNA also enhanced GEF-induced cytotoxicity. (spandidos-publications.com)
The Type 1 group is rather broadly defined and includes pyrethroids containing descyano-3-phenoxybenzyl or other alcohols. (umn.edu)
At the molecular and structural level, mitochondrial biogenesis and mitochondrial function are altered in diabetes, as well as in insulin-resistant relatives of type 2 diabetic subjects ( 1 , 2 ). (diabetesjournals.org)

For a specific biosensor, the sensor contains a receptor, which is a molecule that recognizes the target analyte. (tek.com)

Lipid peroxidation is where free radicals steal electrons in a chain reaction causing oxidation of the fats in cell membranes. (canceractive.com)
Similarly, PGC1α increases the transcription of enzymes necessary for substrate oxidation, electron transport, and ATP synthesis. (diabetesjournals.org)

The green fluorescence of 1-3 is modulated by photoinduced electron transfer (PET) and internal charge transfer (ICT) mechanisms, and by solvent polarity. (rsc.org)

By electron microscopy, most DβH terminals did not make synapses, but when they did, they formed both asymmetric and symmetric synapses. (frontiersin.org)

The following product was used in this experiment: ATPIF1 Polyclonal Antibody from Thermo Fisher Scientific, catalog # 12067-1-AP. (thermofisher.com)

1 It is also debated that coronaviruses can be transmitted by touching the surfaces that an infected person has coughed or sneezed on. (rsc.org)

however, Ferroptosis Suppressor Protein 1 is now known to block ferroptosis, but a changed amino acid metabolism, control of glucose and lipid levels along with minerals such as selenium appear to invoke change. (canceractive.com)

Evidence for GO induced autophagy includes increased levels of isoform B-II microtubule-associated protein 1 light chain 3 (LC3), aggregation of green fluorescence protein-tagged LC3, and increased numbers of autophagic vacuoles in cells. (biomedcentral.com)

Our findings delineate a mechanism in which LLPS of IRS-1-mediated signalosomes serves as an organizing center for insulin/IGF-1 signaling and implicate the role of aberrant IRS-1 LLPS in metabolic diseases. (nature.com)
The 1 H NMR titration and TDDFT studies provide full support of the binding mechanism. (beilstein-journals.org)
Structure and gating mechanism of the acetylcholine receptor pore. (proteopedia.org)
Miyazawa A, Fujiyoshi Y, Unwin N. Structure and gating mechanism of the acetylcholine receptor pore. (proteopedia.org)

In TIO most tumors overexpress the protein fibroblast growth factor-23 (FGF-23) inhibiting renal phosphate reabsorption in the proximal tubules and acting as a phosphaturic factor [ 1 , 3 , 11 ]. (hindawi.com)

Both electrostatic and hydrophobic interactions were seen to drive IRS-1 LLPS. (nature.com)
We previously reported that EphA5 receptor-ephrinA5 interactions within the ventromedial hypothalamus (VMH) influence counterregulatory hormone responses during acute hypoglycemia in nondiabetic rats. (diabetesjournals.org)

IGF-1 stimulation enhanced IRS-1 phase separation which then recruited downstream effectors to form insulin/IGF signalosomes. (nature.com)
We have previously reported that local stimulation of VMH EphA5 receptors by microinjection of ephrinA5-Fc or ephrinA5 overexpression increased, whereas knockdown of VMH ephrinA5 reduced, counterregulatory responses to hypoglycemia. (diabetesjournals.org)
IRS-1 was the first of these to be identified as a 185 kDa protein that is detectable by immunoblot analysis in response to insulin stimulation [ 1 ]. (biomedcentral.com)

we found that the IRS-1 overexpressing cells grow more rapidly than control cells do. (biomedcentral.com)
Our results suggest that overexpression of IRS-1 promotes cells growth, inhibits basal autophagy, reduces oxidative stress-induced autophagy, and diminishes oxidative stress-mediated autophagy-dependent cell death. (biomedcentral.com)
1999. Transactivation activity of human, zebrafish, and rainbow trout aryl hydrocarbon receptors expressed in COS-7 cells: Greater insight into species differences in toxic potency of polychlorinated dibenzo- p -dioxin, dibenzofuran, and biphenyl congeners. (cdc.gov)
A viral etiology, such as measles, has been proposed because nuclear inclusions in diseased osteoclasts that are similar to those seen in paramyxovirus-infected cells have been seen on electron microscopy. (msdmanuals.com)
We were probably the first to describe the electron microscopy finding of the SARS-CoV-2 virus in kidney proximal tubular cells and also in podocytes of the glomerulus. (medscape.com)

S1PRs are lipid-sensing receptors and are therapeutic targets for drug development, including potential treatment of COVID-19. (rcsb.org)
Many illnesses, but particularly degenerative diseases and organ injuries, exhibit lipid peroxidation (1). (canceractive.com)

As a critical node for insulin/IGF signaling, insulin receptor substrate 1 (IRS-1) is essential for metabolic regulation. (nature.com)

Anatomy27

Organisms18

Chemicals and Drugs107

Analytical, Diagnostic and Therapeutic Techniques and Equipment54

Phenomena and Processes44

Disciplines and Occupations8

Technology, Industry, Agriculture6

Information Science8

Health Care1

Cryo-electron m8

AMPA3

Proteins8

Binds1

Mannose-6-phosph1

Ionotropic2

Compounds5

Glutamate1

Membrane5

Paramagnetic resonance2

Synaptic3

Inhibition5

Epidermal3

Subunits6

Microscopy demonstrated2

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Ligands1

Neurons1

GPCRs2

Agonists5

Adenovirus3

Regulate3

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Pathways3

Single-particle2

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20231

Endosomal1

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Postsynaptic2

Isoforms1

Ligand2

Cellular2

EGFR1

Biochemical processes1

Embryonic1

Transmembrane2

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Microscopic2

19941

Spectroscopy2

Chemistry2

Tissue1

Kinases1

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Complexes2

Redox1

19911

Affinity1

Type5

Molecule1

Oxidation2

Mechanisms1

Synapses1

Antibody1

Coronaviruses1

Metabolism1

Green fluorescence1

Mechanism4

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Interactions2

Stimulation3

Cells5

Lipid2

Substrate1