• Title : Technical update : Use of the Determine HIV 1/2 Ag/Ab combo test with serum or plasma in the laboratory algorithm for HIV diagnosis Corporate Authors(s) : Centers for Disease Control and Prevention (U.S.);Association of Public Health Laboratories. (cdc.gov)
  • This study examined pooled human plasma for fractionation to detect PARV4 DNA sequences. (cdc.gov)
  • Also, WF CXCL16 levels were 3-10 times greater than the corresponding plasma concentrations. (nih.gov)
  • If elevated ET-1 concentrations in the peripheral circulation induce RVO, one would suppose it to be experienced in many RVO cases-for example, in normal pressure glaucoma, which is frequently associated with elevated plasma ET-1 values. (bmj.com)
  • 4 Both of these conditions are characterised by normal venous ET-1 concentrations. (bmj.com)
  • The authors' main conclusion that RVOs cause a significant elevation in peripheral venous ET-1 concentrations seems to be relevant. (bmj.com)
  • The method (R/A + robust nanoLC-MS) was used to determine total OT plasma/serum levels to startlingly high concentrations (high pg/mL-ng/mL). (nature.com)
  • Vitamin C intake was assessed by 3-day dietary recall, and plasma and leukocyte vitamin C concentrations were measured colorimetrically. (who.int)
  • HDA was detected in 76% of plasma samples, as heptafluorobutyryl derivatives, and the range of HDA concentrations was or =0.02-0.92 microg l(-1). (cdc.gov)
  • The Thermal Dynamics Cutmaster 58 with 20 foot SL60QD™ 1Torch® is a 60 amp plasma cutter that is ideal for cutting mild steel up to 5/8 inch thick. (bakersgas.com)
  • Thermal Dynamics Cutmaster 60i Plasma Cutter w/20 ft. (cyberweld.com)
  • Suitable for all Thermal Dynamics® Cutmaster® series plasma cutters. (cyberweld.com)
  • This poster was presented at the 58th Annual Meeting of the APS Division of Plasma Physics, and provides an overview of magnetic compression experiments being conducted at General Fusion. (generalfusion.com)
  • These experiments are designed as repetitive non-destructive tests to study plasma physics applicable to General Fusion's magnetized target fusion concept. (generalfusion.com)
  • Plasma accelerators have immense promise for innovation of affordable and compact accelerators for various applications ranging from high energy physics to medical and industrial applications. (wikipedia.org)
  • The average window period of the most sensitive contemporary recombinant protein-based EIA for HIV-1 and HIV-2 antibodies is now 20 days less (4), yielding an average infectious window period of 25 days (95% CI=9-41 days) (5). (cdc.gov)
  • Seven-day-old MDMs were infected with HIV-1 R3A PTAP − YP − for a further 7 days, fixed and processed for cryosection immunolabelling with antibodies against p24/55, and protein A-gold as in Fig. 4 . (biomedcentral.com)
  • Results A panel of genes, proteins and metabolites, including SU 5416 supplier PGE2 and TNF-alpha, were recognized that describe a diclofenac-response network (68 genes in PBMC, 1 plasma protein and 4 plasma metabolites). (woofahs.com)
  • In preliminary experiments with a standard nanoLC-MS set-up (i.e. trap column for extraction + separation column), injecting protein precipitated pooled human plasma clogged the column(s) (see Fig. 1A ). (nature.com)
  • It's based off of our popular BT-1 plasma processing system sharing the same robust and reliable characteristics. (plasmaetch.com)
  • However, plasma accelerators can operate in many different regimes depending upon the characteristics of the plasmas used. (wikipedia.org)
  • Plasma surface modification is one of the processes with high potential that can be used to raise the utility of membrane materials in diverse technical applications. (hindawi.com)
  • Glow discharge plasma at low pressures is one of the several physical techniques utilized to modify the morphology and properties of polymeric membrane surfaces [ 1 ]. (hindawi.com)
  • The marked area from the intracellular plasma membrane-connected compartment (IPMC) is shown at higher magnification in ( b ). c View of the area marked in ( b ) to show the immature phenotype of the budding-arrested virus particles. (biomedcentral.com)
  • Function of Plasma Membrane V-ATPases in Breast Tumor Cell Invasion. (tufts.edu)
  • The a3 and a4 isoforms target V-ATPases to the plasma membrane of osteoclasts and renal intercalated cells, respectively. (tufts.edu)
  • MCF10CA1a cells expressed higher levels of the a3 isoform and higher levels of plasma membrane V-ATPases relative to MCF10a cells, and knockdown of a3 (but not other isoforms) using isoform-specific siRNAs inhibits invasion of MCF10CA1a cells. (tufts.edu)
  • Importantly, overexpression of the a3 isoform in the parental MCF10a cells significantly increased both the level of plasma membrane V-ATPases and in vitro invasion. (tufts.edu)
  • To determine whether expression of V-ATPases at the plasma membrane is important in breast cancer cell invasion, we have employed an inhibitory antibody that selectively blocks plasma membrane V-ATPase activity. (tufts.edu)
  • Inhibition of plasma membrane V-ATPases is shown to significantly reduce invasion of MDA-MB231 cells. (tufts.edu)
  • These studies suggest that human breast tumor cells employ particular a subunit isoforms to target V-ATPases to the plasma membrane, where they aid in tumor cell invasion. (tufts.edu)
  • In the discussion section of the study publication, the authors state that no frank histopathological changes were seen in the livers of the rats exposed to the binary mixture, and that this finding was similar to their previous results with chloroform alone, in which increased plasma ALT occurred without histopathological changes, perhaps due to slight cell membrane damage. (cdc.gov)
  • To study the metabolites of this compound in laboratory animals, we administered it to dogs and rats, and analyzed extracts from dog and rat urine, and from dog plasma, by GC-MS. The metabolic profiles were different in the rat and dog. (aspetjournals.org)
  • The results of present study may be beneficial to comprehend the interaction between two EASWs in laboratory, space and astrophysical plasmas. (frontiersin.org)
  • For example, an experimental laser plasma accelerator at Lawrence Berkeley National Laboratory accelerates electrons to 1 GeV over about 3.3 cm (5.4x1020 gn), and one conventional accelerator (highest electron energy accelerator) at SLAC requires 64 m to reach the same energy. (wikipedia.org)
  • In late 2014, researchers from SLAC National Accelerator Laboratory using the Facility for Advanced Accelerator Experimental Tests (FACET) published proof of the viability of plasma acceleration technology. (wikipedia.org)
  • Mass spectrometric identification of urinary and plasma metabolites of 6-(6'-carboxyhexyl)-7-n-hexyl-1,3-diazaspiro-[4-4]-nonan-2,4-dione, a new cytoprotective agent. (aspetjournals.org)
  • In the dog (plasma and urine), one metabolite was found, and in the rat urine two other metabolites were found. (aspetjournals.org)
  • Measured SU 5416 supplier guidelines included 80 plasma proteins, 300 plasma metabolites (lipids, free fatty acids, oxylipids and polar compounds) and an array of peripheral blood mononuclear cells (PBMC) gene manifestation products. (woofahs.com)
  • Using multiple sequence alignments of human erythroviruses and comparison with the sequence for PARV4 ( 1 ), we designed highly selective primers to the open reading frame 1 (ORF1) of PARV4, homologous to the nonstructural proteins of other parvoviruses. (cdc.gov)
  • Supplementary MaterialsAdditional file 1 Overview of plasma proteins. (woofahs.com)
  • Home / Uncategorized / Supplementary MaterialsAdditional file 1 Overview of plasma proteins. (woofahs.com)
  • OT binds strongly to plasma proteins, but a reduction/alkylation (R/A) procedure breaks this bond, enabling ample detection of total OT. (nature.com)
  • Production of plasma proteins for therapeutic use. (who.int)
  • When the Voyager 1 and 2 spacecraft fl ew through the Jovian system in March and July 1979, the Plasma Science instruments measured ions and electrons in the Io plasma torus and plasma sheet between 4.9 and 42 R J . The dominant ions in the Jovian magnetosphere comprise the fi rst few ionization states of atomic sulfur and oxygen. (mit.edu)
  • The propagation of linear and nonlinear electron acoustic waves (EAWs) in an unmagnetized plasma, comprising dynamical inertial electrons, hot ( r , q ) distributed electrons, warm electron beam, and immobile ions is studied. (frontiersin.org)
  • Plasma acceleration is a technique for accelerating charged particles, such as electrons, positrons, and ions, using the electric field associated with electron plasma wave or other high-gradient plasma structures (like shock and sheath fields). (wikipedia.org)
  • Under normal conditions the plasma will be macroscopically neutral (or quasi-neutral), an equal mix of electrons and ions in equilibrium. (wikipedia.org)
  • However, if a strong enough external electric or electromagnetic field is applied, the plasma electrons, which are very light in comparison to the background ions (by a factor of 1836), will separate spatially from the massive ions creating a charge imbalance in the perturbed region. (wikipedia.org)
  • Protons are 1 - 20% of the plasma between 5 and 30 R J with variable temperatures ranging by a factor of 10 warmer or colder than the heavy ions. (mit.edu)
  • We suggest that these protons, measured deep inside the magnetosphere, are consistent with a source from the ionosphere of ~1.5 - 7.5 × 10 27 protons s 1 (2.5 - 13 kg/s). (mit.edu)
  • Volume 7, Part B of Atomic and Plasma-Material Interaction Data for Fusion is devoted to a critical review of the erosion behaviour of fusion plasma-facing materials due to physical sputtering and radiation-enhanced sublimation, in particular for carbon, beryllium and tungsten. (iaea.org)
  • It is intended to provide fusion reactor designers with a detailed survey and parametrization of existing, critically assessed data for the physical sputtering and radiation-enhanced sublimation of plasma-facing materials by particle impact. (iaea.org)
  • Routine testing for p24 antigen in settings other than blood and plasma centers as a method for diagnosing HIV infection is discouraged because the estimated average time from detection of p24 antigen to detection of HIV antibody is 6 days, and not all recently infected persons have detectable levels of p24 antigen. (cdc.gov)
  • The authors conclude that elevated ET-1 concentration in the peripheral circulation in their patients may be a systemic marker for retinal venous occlusions. (bmj.com)
  • This latter conclusion seems to be unlikely since local retinal vasoconstriction is supposed to be influenced much more by the local ET-1 concentration than the elevation of the systemic venous ET-1 level. (bmj.com)
  • Severe hypertension does influence the systemic ET-1 level. (bmj.com)
  • Several medicines including antihypertensive drugs and, possibly, β receptor blocker eye drops have an influence on systemic ET-1 levels. (bmj.com)
  • Systemic and topical medications should have been compared between the groups in order to rule out their impact on the ET-1 level. (bmj.com)
  • One may speculate that, early after the development of RVO, systemic ET-1 level may increase, then decrease later till the onset of retinal neovascularisation, which might induce an increase again possibly via an increased expression of vascular endothelial growth factor (VEGF), since VEGF can cause an increased expression of endothelin converting enzyme. (bmj.com)
  • Moreover, both macrophages and adipocytes can to push out a selection of inflammatory markers, therefore contributing to an area and systemic condition of "low-grade" swelling [1,2]. (woofahs.com)
  • We conduct blinded, two-phase case-control plasma proteomics on the TEDDY study to identify biomarkers predictive of T1D development. (lu.se)
  • Samples were also collected on postoperative days (POD) 1 and 3 and at various late postoperative time points (POD 7-34). (nih.gov)
  • This prospective observational study aimed to measure pre- and postoperative plasma ascorbic acid levels and examine their association with delirium. (mdpi.com)
  • They are designed to monitor the accuracy and precision of analytical procedures in clinical diagnostics for the quantitative determination of benzodiazepines 1 in serum/plasma. (chromsystems.com)
  • Quantitative plasma biomarker analysis in HDI exposure assessment. (cdc.gov)
  • Samples of manufacturing plasma pools submitted to the National Institute for Biological Standards and Control for testing for hepatitis C virus RNA were stored at -70°C until analysis, in compliance with European regulatory requirements. (cdc.gov)
  • Samples in lanes 1-5 were amplified by using primers directed to open reading frame 1 (ORF1) of PARV4. (cdc.gov)
  • Plasma samples were collected preoperatively from all patients. (nih.gov)
  • Also, they think it possible that the elevated ET-1 level they found in the peripheral blood samples could directly promote the development of retinal vascular occlusions (RVOs). (bmj.com)
  • The proposed method was successfully applied to determination of tramadol in human plasma samples from 10 healthy volunteers after a single oral administration. (unboundmedicine.com)
  • These samples were then torched by the plasma jet for six, 12 or 18 seconds. (livescience.com)
  • The Cutmaster 1-5630-1X features a 20 foot, SL60QD™ 1Torch® with Black Series plasma electrode for up to 60% longer consumables life. (cyberweld.com)
  • The TT-1 is a surface modification system that has a rotating electrode designed to meet the needs of the wire bonding industry. (plasmaetch.com)
  • abstract = 'A gene-drug interaction has been indicated between beta-1 selective beta-blockers and the Arg389Gly polymorphism (rs1801253) in the adrenergic beta-1 receptor gene (ADRB1). (ku.dk)
  • These findings indicate that HDA concentration in hydrolyzed plasma may be used as a biomarker of cumulative inhalation and dermal exposure to HDI and for investigating the effectiveness of exposure controls in the workplace. (cdc.gov)
  • Particles ejected from the Sun that stream through the surrounding plasma of the solar wind are causing instabilities. (aanda.org)
  • Results showed that hydrophilic and gas separation properties of PSF/PEG membranes increased by plasma surface modification. (hindawi.com)
  • Addition of organic or inorganic particle as a third component of the casting solution is one of the most important chemical techniques, while the plasma surface modification is a physical (plasma treatment) and physicochemical (plasma polymerization and grafting) technique. (hindawi.com)
  • Blood donations in the United States have been screened for antibody to human immunodeficiency virus type 1 (HIV-1) since March 1985 and type 2 (HIV-2) since June 1992. (cdc.gov)
  • In the United States, the implementation of antibody testing in 1985 of all donated blood for human immunodeficiency virus type 1 (HIV-1) resulted in a substantial decrease in the transmission of HIV through blood transfusions (1,2). (cdc.gov)
  • To further decrease the risk for transmission of HIV by transfusion, the testing of all blood donations with a combination antibody test for HIV-1 and HIV type-2 (HIV-2) was implemented by June 1992. (cdc.gov)
  • The increased sensitivity of contemporary HIV-antibody EIAs, improved donor interviewing about behaviors associated with risk for HIV infection, and deferral of donors who test positive for HIV, hepatitis, human T-cell leukemia virus type 1 (HTLV-I), or syphilis have considerably improved the safety of the U.S. blood supply. (cdc.gov)
  • Type 1 diabetes (T1D) results from autoimmune destruction of β cells. (lu.se)
  • Plasma sialic acid level also rises in association with metabolic syndrome, including insulin resistance and type-2 diabetes, and appears to be a marker of acute micro vesicular endothelial damage [17-19]. (woofahs.com)
  • We evaluated various workplace factors and controls (i.e. location, personal protective equipment use and paint booth type) as modifiers of plasma HDA levels. (cdc.gov)
  • We report a novel parvovirus (PARV4) and related variants in pooled human plasma used in the manufacture of plasma-derived medical products. (cdc.gov)
  • Effects of direct current glow discharge plasma using argon as working gas on morphological structures and gas separation properties of membranes were studied. (hindawi.com)
  • Most glow discharge plasmas used for these aims are generated from radio frequency (13.56 MHz) and microwave (2.45 GHz) power sources. (hindawi.com)
  • Generally, etching and deposition processes occur at the same time when the polymeric membranes are treated with the discharge plasma from non-polymer forming gases [ 1 ]. (hindawi.com)
  • The DC pulse discharge could generate spark plasma, spark impact pressure, Joule heating, and an electrical field diffusion effect. (hindawi.com)
  • The MS instrument allows unambiguous identification/quantification of e.g. peptides, by first recording the molecular mass of a compound (single MS) and then creating a "molecular fingerprint" by fragmenting the compound to smaller parts (MS/MS). Separating compounds in a mixture (e.g. plasma) prior to MS detection further strengthens identification and sensitivity. (nature.com)
  • Fried and Gould first predicted the existence of electron acoustic waves (EAWs) while studying the numerical solutions of electrostatic dispersion relation in an unmagnetized, homogeneous plasma ( Fried and Gould, 1961 ). (frontiersin.org)
  • Plasma accelerators generally use wakefields generated by plasma density waves. (wikipedia.org)
  • It was also shown that the dosage of PEG and plasma treatment affected the morphological structures and mechanical and gas separation properties. (hindawi.com)
  • The plasma acceleration structures are created either using ultra-short laser pulses or energetic particle beams that are matched to the plasma parameters. (wikipedia.org)
  • These ions clearly come from the plasma interaction with Io ' s atmosphere, but the exact processes whereby atmospheric molecules escape Io and end up as ions well inside Io ' s orbit are not clear. (mit.edu)
  • The spatial regime for the two soliton interaction is found to vary in accordance with the variation of single soliton for various plasma parameters. (frontiersin.org)
  • This volume together with Part A is the result of a five year Co-ordinated Research Project on Plasma-Interaction Induced Erosion of Fusion Reactor Materials in the period 1992-1997. (iaea.org)
  • A positive significant correlation was found between plasma vitamin C and dietary vitamin C intake. (who.int)
  • After log-transformation of the data, the correlation between plasma HDA levels and HDI inhalation exposure measured on the same workday was low (N = 108, r = 0.22, P = 0.026) compared with the correlation between plasma HDA levels and inhalation exposure occurring approximately 20 to 60 days before blood collection (N = 29, r = 0.57, P = 0.0014). (cdc.gov)
  • The correlation between plasma HDA levels and HDI dermal exposure measured on the same workday, although statistically significant, was low (N = 108, r = 0.22, P = 0.040) while the correlation between HDA and dermal exposure occurring approximately 20 to 60 days before blood collection was slightly improved (N = 29, r = 0.36, P = 0.053). (cdc.gov)
  • Plasma alanine aminotransferase (ALT), measured at 24-hour intervals from 24-96 hours after dosing and evaluated as the area under the curve (AUC), was significantly lower in the mixture groups than predicted by the sum of measured responses to each chemical alone, indicating a less-than-effect-additive joint toxic action. (cdc.gov)
  • Plasma and leukocyte vitamin C levels were significantly lower in the asthma group. (who.int)
  • I think plasma will provide additional advantages [in treating cavities], namely by not drilling into or removing dentin so deeply," said Stefan Rupf, an assistant professor of dentistry at Saarland University in Germany and lead author of a study on the work in next month's issue of the Journal of Medical Microbiology. (livescience.com)
  • Because maintaining a safe blood supply is a public health priority, the Food and Drug Administration (FDA) recommended in August 1995 that all donated blood and plasma also be screened for HIV-1 p24 antigen, effective within 3 months of licensure of a test labeled for such use. (cdc.gov)
  • 1995 ) Association of endothelin-1 with normal tension glaucoma: clinical and fundamental studies. (bmj.com)
  • The Cutmaster 1-5830-1 features a 20 foot, SL60QD™ 1Torch. (bakersgas.com)
  • In August 2020 scientists reported the achievement of a milestone in the development of laser-plasma accelerators and demonstrate their longest stable operation of 30 hours. (wikipedia.org)
  • an adjunct study assessed wound fluid (WF) and plasma CXCL16 levels in a separate group of CRC patients. (nih.gov)
  • WF study: In the adjunct study, plasma and WF CXCL16 levels were determined for 23 CRC MICR pts. (nih.gov)
  • WF levels at all time points were significantly elevated over plasma levels. (nih.gov)
  • Plasma CXCL16 levels were elevated for 4 weeks after minimally invasive colorectal resection for cancer. (nih.gov)
  • Increased plasma CXCL16 levels may promote tumor angiogenesis in the first month after MICR. (nih.gov)
  • 1 5 These clinical considerations suggest that the direct influence of peripheral ET-1 levels on the retinal microcirculation is very unlikely. (bmj.com)
  • At very high co-exposure levels, when the enzyme is saturated, the toxicities of chloroform and 1,1-dichloroethylene could be expected to decrease for the majority of sensitive endpoints due to mutual inhibition of each other's metabolism. (cdc.gov)
  • The prevalence lowered in asthmatic patients and that the and morbidity rate of asthma have in- duration of asthma affects plasma and leu- creased in the past decade, despite kocyte vitamin C levels. (who.int)
  • In this study, we describe the quantification of 1,6-hexamethylene diamine (HDA) levels in hydrolyzed plasma of 46 spray painters applying 1,6-hexamethylene diisocyanate (HDI)-containing paint in vehicle repair shops collected during repeated visits to their workplace and their relationship with dermal and inhalation exposure to HDI monomer. (cdc.gov)
  • the variations in zinc levels over the course of anti-TB therapy after 1 and 4 months. (who.int)
  • Plasma Abeta(1-40) and Abeta(1-42) and the risk of dementia: a prospective case-cohort study. (alzforum.org)
  • van Oijen M, Hofman A, Soares HD, Koudstaal PJ, Breteler MM . Plasma Abeta(1-40) and Abeta(1-42) and the risk of dementia: a prospective case-cohort study . (alzforum.org)
  • In this study, we explore the possibility of using atmospheric pressure plasma as a dry process to treat 100% grey cotton knitted fabric (single jersey and interlock) before processing. (mdpi.com)
  • A new study shows that bacteria-killing jets of plasma could soon replace the drills used to treat cavities in our teeth, making visits to the dentist's office a bit less nerve-racking. (livescience.com)
  • Parish Sedghizadeh is an assistant professor at the University of Southern California School of Dentistry who works with plasmas but was not involved with the new study. (livescience.com)
  • Asthma is a chronic relapsing inflammatory study in Tehran with the hypothesis that disorder of the airways and a major health plasma and leukocyte vitamin C level are problem worldwide [ 1 ]. (who.int)
  • The adequate vitamin C intake has been associ- diagnosis of asthma was established from a ated with the protective effects of airways documented clinical history of recurrent responsiveness and lung function [ 1,5-7 ]. (who.int)
  • CRC patients who had MICR and for whom plasma was available in a tissue bank were eligible. (nih.gov)
  • One supposes that all patients were on medication at the time of the blood sampling for ET-1 measurements. (bmj.com)
  • For further discussion on HIV-2 RNA monitoring in patients with HIV-1/HIV-2 coinfection or HIV-2 mono-infection, see the HIV-2 Infection section. (hiv.gov)
  • Une corrélation significative positive a été trouvée entre la vitamine C plasmatique et l'apport alimentaire en vitamine C. Le taux de vitamine C plasmatique et leucocytaire était significativement moins élevé dans le groupe des patients asthmatiques. (who.int)
  • Survey of Voyager plasma science ions at Jupiter: 1. (mit.edu)
  • Na + ions are detected between 5 and 40 R J at an abundance of 1 to 10%, produced by the ionization of the extended neutral cloud emanating from Io that has been observed since 1974. (mit.edu)
  • Total nucleic acid was extracted from plasma pools as described previously ( 4 ) before analysis for PARV4 DNA. (cdc.gov)
  • The mean preoperative plasma CXCL16 level was 2.36 ± 0.57 ng/ml. (nih.gov)
  • E ditor ,-I read with interest the article by Iannaccone et al 1 on the connection between venous plasma endothelin-1 (ET-1) level and retinal vein occlusions (RVO). (bmj.com)
  • It would have been especially interesting and might have supported the authors' hypothesis on the marker role of venous ET-1 level, if time dependency of the ET-1 level had been investigated individually, at least in the early cases. (bmj.com)
  • A significant association was observed between duration of asthma and plasma vitamin C level. (who.int)
  • Perricone MD Cold Plasma Plus+ Advanced Serum Concentrate, 1 oz. (macys.com)
  • This cold plasma does not seem like the original? (macys.com)
  • This purple beam of "cold" plasma could help kill germs as part of cavity treatments one day. (livescience.com)
  • Instead, "cold" plasmas with a temperature of about 100 degrees Fahrenheit (38 degrees Celsius) are made in the lab by partially ionizing helium gas with pulses of microwaves lasting just millionths of a second. (livescience.com)
  • These lyophilised quality controls from Chromsystems are based on human plasma and should be used according to the instruction manual. (chromsystems.com)
  • We describe a robust nano liquid chromatography-mass spectrometry (nanoLC-MS) platform for measuring the total amount of OT in human plasma/serum. (nature.com)
  • Using a sequence-independent polymerase chain reaction (PCR) amplification method, we recently identified a new parvovirus in plasma from a patient with exposures and symptoms consistent with acute HIV infection, but who was HIV RNA negative ( 1 ). (cdc.gov)
  • Depending on the beam density, temperature and velocity, we get a critical condition for which the quadratic nonlinearity vanishes from the plasma system. (frontiersin.org)
  • You can provide feedback direct to the developers via the #Plasma IRC channel , Plasma-devel mailing list or report issues via Bugzilla . (kde.org)