• Three types of lipids were assessed (1,2-Dioleoyl-sn-glycero-3-phosphocholine (DOPC), 1,2-Distearoyl-sn-glycero-3-phosphocholine (DSPC) and 1,2-distearoyl-sn-glycero-3-phospho-rac-(1-glycerol) (DSPG)), separately and in mixtures, forming anionic liposomes with good physicochemical characteristics, high entrapment efficiencies (varying from 56.5 to 89.4%), satisfactory in vitro release profiles and good physical stability. (mdpi.com)
  • dimyristoylphosphatidylcholine or dipalmitoylphosphatidylcholine liposomes had no effect. (villanova.edu)
  • Antioxidant effects were fluorometrically determined using diphenyl-1-pyrenylphosphine-incorporated liposomes which were treated with 10 - 100 μM phenols, and then peroxidized with 10 μM peroxynitrite. (oalib.com)
  • When administered intravenously to C57BL/6J mice bearing melanoma B16F1 tumour at 10 mg kg-1 dose, liposomal bleomycin in combination with hyperthermia (43°C, 30 min or 1 h) exhibited improved anticancer activity as evident by the enhanced volume doubling time and growth delay compared with animals treated with an equivalent dose of free bleomycin with or without hyperthermia. (elsevier.com)
  • Treatment of differentiated epithelial cells with secretagogues stimulated the secretion of functional surfactant-containing surfactant proteins B and C (SP-B and SP-C). Secreted material was further enriched in this same set of phospholipid species but was characterized by increased contents of short-chain monounsaturated and disaturated species other than dipalmitoyl PC (PC16:0/16:0), principally palmitoylmyristoyl PC (PC16:0/14:0) and palmitoylpalmitoleoyl PC (PC16:0/16:1). (biomedsearch.com)
  • 10 µCi quantities of L-α-DiPalmitoyl-[DiPalmitoyl-1- 14 C]-Phosphatidylcholine are available for your research. (perkinelmer.com)
  • Here, we employ the phase-sensitive membrane dye di-4-ANEPPDHQ together with a variety of spectrally-resolved microscopy techniques, including 2-channel ratiometric TIRF microscopy and fluorescence lifetime imaging, to characterize membrane order at the T cell immunological synapse at high spatial and temporal resolution in live cells at physiological temperature. (ox.ac.uk)
  • Whether interactions between synaptotagmin-1 (syt-1) and the soluble NSF attachment protein receptors (SNAREs) are required during neurotransmission is debated. (jneurosci.org)
  • We examined five SNAP-25 mutations designed to interfere with syt-1 interactions. (jneurosci.org)
  • SIGNIFICANCE STATEMENT The function of synaptotagmin-1 (syt-1):soluble NSF attachment protein receptor (SNARE) interactions during neurotransmission remains unclear. (jneurosci.org)
  • Figure 1 ), a chiral pair of natural naphthoquinone compounds, biosynthesized in the roots of more than 150 species of the Boraginaceae plant family (such as lithospermum , Alkanna , Anchusa and Echium) are widely used due to their various pharmacological activities. (mdpi.com)
  • We conclude that three synaptic release functions of syt-1, vesicle priming, spontaneous release clamping, and evoked release triggering, depend on direct SNARE complex interaction. (jneurosci.org)
  • Therefore, vesicle priming, clamping spontaneous release, and eliciting evoked release are three different functions of syt-1 that involve different interaction modes with the SNARE complex. (jneurosci.org)
  • In the same context, cholesterol has been shown to modulate AEA binding to the CB 1 (type-1 cannabinoid receptor) [ 9 ] and the TRPV1 (type-1 vanilloid receptor) [ 10 ]. (biochemj.org)
  • These membrane preparations were treated with phenols and anesthetics at 1 - 200 μM, followed by measuring the fluorescence polarization to determine the membrane interactivities to change membrane fluidity. (oalib.com)
  • 2. The method of claim 1 in which the cation is selected from the group consisting of calcium, manganese and magnesium. (patentgenius.com)
  • Clinical assessments for efficacy and tolerability were conducted at baseline, baseline post-application, week 2, and week 4. (readbyqxmd.com)
  • Lactocin 705 exerted an inhibitory effect on the indicator strain Lactobacillus plantarum CRL691 with an optimal Lac705α/Lac705β peptide ratio of 1 to 4. (asm.org)
  • 1,2 Recent studies suggest that statins may also have anti-inflammatory properties. (ahajournals.org)
  • or (3) infusions of HDL (8 mg/kg apolipoprotein A-I) on days 1 and 3 of the treatment phase. (ahajournals.org)