• A striking finding was that PPL films containing the complete mix of surfactant phospholipids had greatly improved dynamic respreading corn, pared to DPPC, particularly surface excess films (30 and 15 Å 2 /molecule). (elsevier.com)
  • Hydrophobic gave an additional increase in dynamic respreading in SP and PL compared to PPL films for initial concentrations of 60, 30, and 15 Å 2 /molecule. (elsevier.com)
  • Spread films of SP and PL at 60 and 30 Å 2 /molecule had lower maximum pressures than PPL, but maximum pressures were slightly larger for SP and PL films at high initial concentration (15 Å 2 /molecule). (elsevier.com)
  • 1984). In a preliminary comparative metabolism study in rats, groups each of 2 animals were given 14 C-labelled alpha-cyclodextrin, -cyclodextrin or gelatinised potato starch by gavage as approximately 2.5 ml of a 2.5% aqueous solution. (inchem.org)
  • When administered intravenously to C57BL/6J mice bearing melanoma B16F1 tumour at 10 mg kg-1 dose, liposomal bleomycin in combination with hyperthermia (43°C, 30 min or 1 h) exhibited improved anticancer activity as evident by the enhanced volume doubling time and growth delay compared with animals treated with an equivalent dose of free bleomycin with or without hyperthermia. (elsevier.com)
  • Pharmaceutics: Special Issue: Liposomal Technologies ]] (2014): 6: 1-20. (openwetware.org)
  • Using a pulsating bubble surfactome-ter, we found that inflation pressures of bubbles at minimum radii in these mixtures were 0.34 ± 0.05 cm H 2 0 (± SD, n = 24) after 1 min. (elsevier.com)
  • We conclude that three synaptic release functions of syt-1, vesicle priming, spontaneous release clamping, and evoked release triggering, depend on direct SNARE complex interaction. (jneurosci.org)
  • Therefore, vesicle priming, clamping spontaneous release, and eliciting evoked release are three different functions of syt-1 that involve different interaction modes with the SNARE complex. (jneurosci.org)
  • Abstract No. 004429, NIshijima M. et al, `Detergent Resistant Phospho Lipase A of Escherichia-Coli K-12 Purification and Properties` of Eur J Biochem, 73 (1) 1977 115-124. (patentgenius.com)
  • The respiratory distress syndrome (RDS) of the newborn, due to hyaline membrane disease, is caused by an inability of the fetal or neonatal lung to synthesize adequate quantities of the lipoprotein, surfactant (1). (springer.com)
  • The first of these, a derivative of the Danielle model, (2) requires that the lipid component of the membrane be a bilayer in structure and contribute to the membrane its basic barrier properties. (springer.com)
  • FAAH (fatty acid amide hydrolase) is a membrane-bound enzyme that is responsible for the intracellular hydrolysis of the bioactive lipid AEA (anandamide or N -arachidonoylethanolamine) and other congeners known as eCBs (endocannabinoids) [ 1 ]. (biochemj.org)
  • In the case of neurotransmitter release, the synaptic vesicle-bound v-SNARE VAMP 2 interacts with its cognate t-SNARE, consisting of syntaxin 1 and SNAP-25, on the presynaptic plasma membrane. (rupress.org)
  • These membrane preparations were treated with phenols and anesthetics at 1 - 200 μM, followed by measuring the fluorescence polarization to determine the membrane interactivities to change membrane fluidity. (oalib.com)
  • Here, we employ the phase-sensitive membrane dye di-4-ANEPPDHQ together with a variety of spectrally-resolved microscopy techniques, including 2-channel ratiometric TIRF microscopy and fluorescence lifetime imaging, to characterize membrane order at the T cell immunological synapse at high spatial and temporal resolution in live cells at physiological temperature. (ox.ac.uk)
  • 4. The process of claim 1, wherein said fusogen is a fatty acid, sterol or phospholipid which when included in a phospholipid bilayer renders the bilayer capable of fusion with integral membrane proteins when any component of the bilayer is at or below the phase transition temperature. (freepatentsonline.com)
  • 7. The process of claim 1, wherein said integral membrane protein is bacteriorhodopsin, UDP-glucuronyltransferase, cytochrome oxidase, insulin receptor or βC 1 complex. (freepatentsonline.com)
  • 8. The process of claim 1, wherein said integral membrane protein is used in an amount such that the lipid to protein ratio (wt/wt) is 100/1 to 1/10. (freepatentsonline.com)
  • Two fluorescent probes, which insert into different regions of the bilayer, were selected: 1,6-diphenyl-1,3,5-hexatriene (DPH) was located at the deep hydrophobic core of the acyl chain regions and 2-dimethylamino-6-lauroylnaphthalene (Laurdan) at the hydrophilic-hydrophobic membrane interface. (escholarship.org)
  • Lactocin 705 exerted an inhibitory effect on the indicator strain Lactobacillus plantarum CRL691 with an optimal Lac705α/Lac705β peptide ratio of 1 to 4. (asm.org)
  • 2) Design, synthesis, and biophysical studies of sequence-controlled, biomimetic oligomers (synthetic peptide mimics) with helical structures, for biomedical and biomaterial applications (mimicry of lung surfactant proteins, antimicrobial and anticancer innate immune peptides). (stanford.edu)
  • The changes caused by cyclosporin A were assessed by the first moment (M 1 ) and order parameters calculated from the spectra. (elsevier.com)
  • The presence of cyclosporin A decreases the magnitude of M 1 at temperatures below the gel to liquid-crystalline state, cyclosporin A causes an increase in the order parameters along the acyl chains which suggests that cyclosporin A is located along the acyl chains of the phospholipid. (elsevier.com)
  • A synthetic phosphatidylglycerol-free surfactant however, was shown to further improve CATH-2 delivery and function at a remote site. (nature.com)
  • Approximately half of the fluorescence intensity was lost over a 1 week period following challenge of lavaged macrophage. (cdc.gov)
  • 8. A method for treating respiratory distress syndrome in mammals wherein natural lung surfactant normally produced by the mammal is absent or deficient, comprising introducing into the alveolar spaces a quantity of a composition consisting essentially of a major amount of 1,2 dipalmitoyl-sn-3-glycerophosphoryl choline in admixture with a minor amount of a fatty alcohol. (google.es)
  • Contrary to bigger particles, which get stuck in the upper respiratory ways, nanometre-sized particles can reach the gas-exchange surface in the alveoli [ 1 ], which is lined with a monolayer of lung surfactant [ 4 ]. (royalsocietypublishing.org)
  • Minimum inflation pressures were similar to those of modified bovine surfactant, surfactant Tokyo Akita (TA) (0.33 ± 0.05 cm H 2 0, n = 7). (elsevier.com)
  • Treatment of differentiated epithelial cells with secretagogues stimulated the secretion of functional surfactant-containing surfactant proteins B and C (SP-B and SP-C). Secreted material was further enriched in this same set of phospholipid species but was characterized by increased contents of short-chain monounsaturated and disaturated species other than dipalmitoyl PC (PC16:0/16:0), principally palmitoylmyristoyl PC (PC16:0/14:0) and palmitoylpalmitoleoyl PC (PC16:0/16:1). (biomedsearch.com)
  • The synthetic surfactant composition consists essentially of a major amount of 1,2-dipalmitoyl-sn-3-glycerophosphoryl. (google.es)
  • It has been demonstrated that the Type II ce1I of the lung synthesizes surfactant, a substance which markedly lowers the surface tension of the lung, preventing alveolar collapse (2). (springer.com)
  • The lipid composition of surfactant is illustrated in Figure 1. (springer.com)
  • SP-A, as well as the enzyme lysophosphatidylcholine acyltransferase-1 (LPCAT1), required for synthesis of surfactant dipalmitoylphosphatidylcholine, and the proinflammatory glycerophospholipid platelet-activating factor (PAF) were markedly reduced in SRC-1/-2-deficient fetal lungs near term. (jci.org)
  • Control and surfactant-treated dusts were used to challenge lavaged rat pulmonary macrophages in vitro over a 1-week period, to determine the effects of adsorbed surfactant on the expression of quartz cytotoxicity and genotoxicity. (cdc.gov)
  • Cytotoxicity of surfactant-treated quartz measured one day after challenge of lavaged macrophages was suppressed to values near those of the negative controls, and then increased over a 1 week incubation period to levels near those expressed by native quartz positive controls. (cdc.gov)
  • CATH-2 can kill bacteria through a diverse range of antibacterial pathways and exogenous surfactant can improve pulmonary drug distribution. (nature.com)
  • Unfortunately, simply mixing CATH-2 or other AMPs with a commercial exogenous surfactant has been shown to impact a drug's therapeutic efficacy 5 , 8 . (nature.com)
  • For example, we recently demonstrated that an exogenous surfactant with CATH-2, exhibited antimicrobial activity against antibiotic-resistant bacterial isolates from cystic fibrosis patients, albeit with less efficacy than CATH-2 by itself 5 . (nature.com)
  • 1) Molecular and cellular biophysics of human innate immunity, with a focus on the pleiotropic roles of host defense peptides and amyloidogenic peptides in human health and disease, including infectious disease, cancer, and plaque diseases. (stanford.edu)
  • 2. The hydrogel particles of claim 1, which further comprise one or more entrapped substances therein selected from the group consisting of drugs, vitamins, growth factors, hormones, peptides, polypeptides, proteins and oligonucleotides, which are entrapped by entrapping said substances in said hydrogel particles during formation thereof. (google.co.uk)
  • One proposed strategy is the use of exogenous surfactants to deliver antimicrobial peptides (AMPs), like CATH-2, to infected regions of the lung. (nature.com)
  • Polymorphic forms of 1,2-dipalmitoyl-sn-glycerol: a combined X-ray and electron diffraction study 的翻译是: 是什么意思?英文翻译中文,中 (woyaofanyi.com)
  • In vertebrates the N-terminal WIF domain (WIF-1(WD)) of Wnt inhibitory factor 1 (WIF-1) binds Wnt ligands. (rcsb.org)
  • Here, we evaluated the contribution of steroid receptor coactivators 1 and 2 (SRC-1 and SRC-2), which upregulate SP-A transcription, to the parturition process. (jci.org)
  • on Bone Nodule Formation and Expression of Bone Morphogenetic Protein 2, Osteocalcin, Osteopontin, Alkaline Phosphatase, and Type I Collagen mRNA in Long-Term Cultures of Fetal RatCalvarial Osteoblasts,"600 J Bone Miner Res (1994) 9:855-863. (patentgenius.com)
  • 1990 Mar 30;1023(1):12-18. (elsevier.com)
  • Exogenous Transforming Growth Factor-Beta 2 Enhances Connective Tissue Formation and Wound Strength in Guinea Pig Dermal Wounds Healing by Secondary Intent," Ann Surg (1990) 211(3):288-294. (patentgenius.com)
  • Abstract No. 066261, Zhang Y et al, `Purification and Characterization of aLysophospholipase from a Macrophage-Like Cell Line P388D-1` of J. Biol. (patentgenius.com)
  • EXPLANATION -Cyclodextrin is a cyclic heptamer composed of seven glucose units joined "head-to-tail" by alpha-1,4 links. (inchem.org)