• 2021 Mar 1;42(3):466-474. (umc.edu)
  • 2021 Mar 1;42(3):438-441. (umc.edu)
  • 2021 Jan 30;13(1):e13022. (umc.edu)
  • 2021 Apr 1;184(7):1895-1913.e19. (nih.gov)
  • Geneva: World Health Organization (https://www.who.int/health-topics/coronavirus#tab=tab_1, accessed 7 May 2021). (who.int)
  • These results suggest that differential expression of Apaf-1 and caspase-3 genes may underlie regulation of apoptotic susceptibility during brain development, as well as after acute injury to mature brain, through the intrinsic pathway of caspase activation. (jneurosci.org)
  • Our results indicate that canonical WNT signaling can collaborate with or antagonize the AP-1 transcription factor to fine-tune the expression of shared target genes in the colorectal epithelium. (duke.edu)
  • 2007. Maternal nutrient restriction in early pregnancy programmes hepatic mRNA expression of growth related genes and liver size in adult male sheep . (hutton.ac.uk)
  • A presente revisão destaca os genes e polimorfismos genéticos atualmente estudados, indicados como tendo influência na gênese da EI, como os genes MMP-3, IL-6, do colágeno tipo 1, de receptores de vitamina D e de estrógenos. (scielo.br)
  • En ese sentido, existe un creciente enfoque en la identificación de genes, polimorfismos genéticos asociados y loci de susceptibilidad múltiples. (scielo.br)
  • La presente revisión destaca los genes y polimorfismos genéticos actualmente estudiados, identificados como influyentes en la génesis de la EI, como los genes MMP-3, IL-6, colágeno tipo 1 y receptores de vitamina D y de estrógeno. (scielo.br)
  • Also, under/over-expression studies of the master regulator Oct4 have revealed that some self-renewal/pluripotency as well as differentiation genes are expressed in a biphasic manner with respect to the concentration of Oct4. (lu.se)
  • This analysis supports the GGI as a good predictor of relapse for ER-positive patients, even among patients who receive L. Validation of these results, in a larger series from BIG 1-98, is planned using the simplified GGI represented by a smaller set of genes and tested by qRT-PCR on paraffin-embedded tissues. (biomedcentral.com)
  • Bortoluzzi S, Alessi FD, Romualdi C, Danieli GA: Differential expression of genes coding for ribosomal proteins in different human tissues. (karger.com)
  • Mainz/Martinsried/Munich, Germany, 21 February 2022 - BioNTech SE (Nasdaq: BNTX, "BioNTech") and Medigene AG (FSE: MDG1, Prime Standard, "Medigene"), a clinical-stage immuno-oncology company focusing on the development of T cell immunotherapies, today announced that they have entered a multi-target research collaboration to develop T cell receptor (TCR) based immunotherapies against cancer. (pressetext.com)
  • Injury-induced cytochrome c -specific cleavage of caspase-9 followed by activation of caspase-3 in mature brain correlated with marked increases in Apaf-1 and caspase-3 mRNA and protein expression. (jneurosci.org)
  • ETS-1 and ETS-2 mRNA and protein levels were much higher in the ocular tissues of Tyrp-1-TAg mice than in control ocular tissues from wild-type mice. (molvis.org)
  • 2020 Oct 1;146(10):981. (umc.edu)
  • 2020 Nov 29:1-15. (umc.edu)
  • 2020). Long non-coding RNA lnc-DC in dendritic cells regulates trophoblast invasion via p-STAT3-mediated TIMP/MMP expression. (umaryland.edu)
  • 2020 Apr 3;11(1):1667. (uni-wuerzburg.de)
  • 2020 Mar 13;11(1):1356. (uni-wuerzburg.de)
  • Specifically, it focuses on the requests made in paragraphs 9(1-10) of resolution WHA73.1 (2020), capturing WHO's work as a representation of collective actions and achievements together with Member States and a wide range of partners including United Nations bodies, civil society organizations and national and local nongovernmental organizations. (who.int)
  • In cell culture systems, the luminal ERα + tumor cells are either outcompeted by other types of cells or the cells rapidly downmodulate ERα expression 5 . (nature.com)
  • In vivo, stable ERα expression has been reported in patient-derived xenograft (PDX) models, especially in tumor cells introduced via intraductal transplantations 8 , 9 and these findings have suggested a strong microenvironment-dependent dynamic component in the regulation of ERα expression. (nature.com)
  • The directed expression of SV40 T antigen has led to the development of several important transgenic models with spontaneous epithelial tumor formation. (molvis.org)
  • EDIL3 promotes adherence and migration of endothelial cells, and acts as an endothelial cell survival agent through upregulation of Bcl-2 expression. (rndsystems.com)
  • Our previous studies indicated that knockdown of the p65 gene or IKKβ inhibited lipopolysaccharide (LPS)-induced upregulation of TF and PAI-1 in rat AECII ( 15 , 16 ), indicating that the NF-κB signaling pathway participates in coagulation and fibrinolysis regulation in LPS-treated AECⅡ cells. (spandidos-publications.com)
  • We also demonstrated upregulation of ETS-1 and ETS-2 target expressions in Tyrp-1-TAg mice when comparing with the same target expressions in control mice. (molvis.org)
  • Here we demonstrate that, during brain maturation, the potential of the intrinsic apoptotic pathway is progressively reduced and that such repression is associated with downregulation of apoptotic protease-activating factor-1 (Apaf-1) and caspase-3 gene expression. (jneurosci.org)
  • Future therapeutic strategies for APC-deficient colorectal cancers might be expanded to include agents targeting the AP-1 pathway. (duke.edu)
  • The aim of the present study was to determine whether BAY11‑7082, an inhibitor of the NF‑κB pathway, inhibits the expressions of tissue factor (TF) and plasminogen activator inhibitor‑1 (PAI‑1) in AECⅡ in response to TNF‑α. (spandidos-publications.com)
  • In the phenylpropanoid biosynthesis pathway, the increased expression of 4-coumarate (1.13-fold) and sinapyl alcohol (1.26-fold) triggered by g-C3N4 coexposure with Cd or As played a critical role in promoting plant growth and enhancing rice resistance against metal(loid) stresses. (bvsalud.org)
  • That is, the controlled gene expression during transcription and translation coupled with the rearrangements of immunoglobulin gene segments result in the generation of antibody repertoire during development and maturation of B cells. (wikipedia.org)
  • Immunization with Pneumocystis Cross-Reactive Antigen 1 (Pca1) Protects Mice against Pneumocystis Pneumonia and Generates Antibody to Pneumocystis jirovecii. (rochester.edu)
  • Osteonectin expression was evaluated using immunohistochemistry with anti-secreted protein acidic and rich in cystein (anti-SPARC) antibody. (bvsalud.org)
  • In addition, the expression of ICAM-1 in lung parenchyma in areas outside the granulomas of OVA-orally tolerant mice was significantly reduced. (hindawi.com)
  • We have studied the transgenic mouse strain, Tyrp-1-TAg, to try to gain insight into possible molecular mechanisms common to pigmented ocular neoplasms occurring spontaneously in the eyes of these mice and human choroidal melanoma. (molvis.org)
  • This is the first study describing the production and distribution of ETS-1 and ETS-2 mRNAs and proteins using in situ hybridization and immunohistochemistry in murine ocular tissue sections of normal control eyes and tumoral eyes from mice of the same age. (molvis.org)
  • Using semi-quantitative reverse-transcription polymerase chain reaction (RT-PCR) and western blots experiments, we compared changes in ETS-1 and ETS-2 expression, their protein levels, and the regulation of some of their target gene expressions at different stages of the ocular tumoral progression in the transgenic mouse model, Tyrp-1-TAg, with those in normal eyes from control mice of the same age. (molvis.org)
  • CFTR expression, S1P concentrations, and immune cell frequencies were determined in vehicle- and C18-treated HF mice and sham controls using Western blotting, flow cytometry, mass spectrometry, and qPCR. (lu.se)
  • Diazinon immunotoxicity in mice: Modulation of cytokines level and their gene expression. (cdc.gov)
  • Pulmonary inflammation can damage pulmonary vascular endothelial cells and type-II alveolar epithelial cells (AECII), which further increases the expression of tissue factor (TF) and plasminogen activator inhibitor-1 (PAI-1) in these cells, thus activating the exogenous coagulation system. (spandidos-publications.com)
  • 2013. Regulation of RNA-dependent RNA polymerase 1 and isochorismate synthase gene expression in arabidopsis . (hutton.ac.uk)
  • Breast cancers are commonly divided into four molecular subtypes based on specific therapeutically actionable biomarkers and gene expression profiles 1 . (nature.com)
  • Scholars@Duke publication: Chromatin-associated APC regulates gene expression in collaboration with canonical WNT signaling and AP-1. (duke.edu)
  • NF‑κB signaling regulates the expression of molecules associated with coagulation and fibrinolytic inhibition in type‑II alveolar epithelial cells (AECII) stimulated by lipopolysaccharide. (spandidos-publications.com)
  • One potential mechanism underlying the persistent effects of stress on visceral sensitivity could be epigenetic modulation of gene expression. (frontiersin.org)
  • also Del-1 and integrin-binding DEL1) is a 52 kDa extracellular matrix protein that is expressed by endothelial tissues during embryonic vascular development. (rndsystems.com)
  • Oral tolerance is a T-cell-mediated phenomenon described as the inhibition of immune responsiveness to a protein previously contacted by the oral route [ 1 , 2 ]. (hindawi.com)
  • TNF‑α significantly promoted TF and PAI‑1 expression either at the mRNA or protein level in AECII cells. (spandidos-publications.com)
  • Overcoming Taxane Resistance: Preclinical and Phase 1 Studies of Relacorilant, a Selective Glucocorticoid Receptor Modulator, with Nab-Paclitaxel in Solid Tumors. (ucsf.edu)
  • We have previously shown that the Gene expression Grade Index (GGI) was able to identify two subtypes of estrogen receptor (ER)-positive tumors that were associated with statistically distinct clinical outcomes in both untreated and tamoxifen-treated patients. (biomedcentral.com)
  • Systemically, HF associated with higher S1P plasma levels compared to sham-operated controls and presented with higher S1P receptor 1-positive immune cells in the spleen. (lu.se)
  • 1994. Ah receptor in embryonic mouse palate and effects of TCDD on receptor expression. (cdc.gov)
  • HF led to decreased pulmonary CFTR expression, which was accompanied by elevated S1P concentrations and a pro-inflammatory state in the lungs. (lu.se)
  • CFTR correction with C18 attenuated the HF-associated alterations in pulmonary CFTR expression and, hence, led to lower pulmonary S1P levels, which was accompanied by reduced lung inflammation. (lu.se)
  • Chronic beryllium disease (CBD) provides a human disorder in which to study the delayed type IV hypersensitivity response to persistent Ag that leads to noncaseating pulmonary granuloma formation. (cdc.gov)
  • Ag that leads to noncaseating pulmonary granuloma formation. (cdc.gov)
  • As part of this collaboration an annotation system, named Euporia has been developed in order to offer digital support to the historico-anthropological study [1] carried out by the first author, as part of her doctoral research, on the dramatic functions of rituals in ancient Greek tragedy, ( Mugelli 2018b, defended on November 15 2018 ). (digitalhumanities.org)
  • Structure 2018 Jan 2;26(1):137-144.e3. (uni-wuerzburg.de)
  • Expression of large T-antigen (LT-Ag) and p53 within a subset of tumors. (cdc.gov)
  • Previous data has reported similarity between human brain and testis gene expression patterns. (karger.com)
  • Hence, it means that human testis could also play a crucial role in human speciation if these two tissues exhibit similar gene expression patterns. (karger.com)
  • Determining the large scale anatomy of gene expression patterns of various human tissues could draw a more convincing conclusion, and better our understanding of the correlation/inter-correlation among different tissues. (karger.com)
  • Among the 17 tissues, the highest similarity in gene expression patterns was between human brain and testis, based on DDD and clustering analysis. (karger.com)
  • Present results provide evidence to support the proposal that human testis and brain share the highest similarity of gene expression patterns. (karger.com)
  • Concentrations of TF and PAI‑1 in supernatant also significantly increased upon TNF‑α stimulation. (spandidos-publications.com)
  • Our data demonstrate that beryllium-stimulated bronchoalveolar lavage cells produce IL-10, and the neutralization of endogenous IL-10 does not increase significantly cytokine production, HLA expression, or T lymphocyte pro- liferation. (cdc.gov)
  • 2016. RNA-dependent RNA polymerase 1 in potato (Solanum tuberosum) and its relationship to other plant RNA-dependent RNA polymerases . (hutton.ac.uk)
  • Address correspondence to: Paolo Giacobini, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Lille Neuroscience & Cognition UMR-S 1172, 1 Place de Verdun, 59045, Lille, France. (jci.org)
  • bronchoalveolar lavage cells from control and CBD subjects to evaluate the beryllium salt-specific production of endogenous IL-10 and the effects of exogenous human rIL-10 (rhIL-10) on HLA expression, on the production of IL-2, IFN- , and TNF- , and on T lymphocyte proliferation. (cdc.gov)
  • exogenous rhIL-10 has a limited effect on cytokine production and no effect on T lymphocyte proliferation or HLA expression. (cdc.gov)
  • Reduction of granulomas by reexposure to orally tolerated proteins was not correlated with a shift in Th-1/Th-2 cytokines in serum or lung tissue extract. (hindawi.com)
  • Similarly to other inflammatory reactions, one critical aspect of granuloma formation is leukocyte migration dependent on the expression of adhesion molecules and cytokines [ 14 , 18 , 19 ]. (hindawi.com)
  • To inves- inflammatory cytokines and the timing of their production support tigate the interplay of proinflammatory and anti-inflammatory cyto- an immunologic response appropriate to the amount of Ag and kines in human granulomatous disease, we evaluated the ability of duration of exposure. (cdc.gov)
  • Hypercoagulability and fibrinolytic inhibition, either systemic or in lung tissue, are important characteristics of acute respiratory distress syndrome (ARDS) ( 1-4 ). (spandidos-publications.com)
  • The RGD motif of EDIL3 binds alpha v beta 5 integrin, which, in turn, leads to increased angiogenic transcription factor HoxD3 expression. (rndsystems.com)
  • LT-Ag is expressed within the nuclei of a subset of neoplastic astrocytes in 2 independent tumors. (cdc.gov)
  • p53 co-localizes with LT-Ag within nuclei of neoplastic cells. (cdc.gov)
  • In normal control adult mouse eyes, ETS-1 was mostly present in the nuclei of all neuroretinal layers whereas ETS-2 was mostly localized in the cytosol of the cell bodies of these layers with a smaller amount present in the nuclei. (molvis.org)
  • Some of the receptors are cation channels, which can directly depolarize the nociceptor upon activation, while other receptors activate second messenger systems to change neuronal excitability by changing expression of, or modifying the function of, other cation channels. (frontiersin.org)
  • LINE-1 retrotransposons drive human neuronal transcriptome complexity and functional diversification. (lu.se)
  • At the core of the network reside Oct4, Sox2 and Nanog, into embryonic stem cells [1,2,3,4,5], have made major inroads which form a self-organized core of the TFs maintaining into stem cell biology. (lu.se)
  • 1, 7, 8, 11, 17] Our research group has recently completed an extensive compilation of the K+ and Na+ concentrations found in more than 1200 wild and domesticated unsalted foods from all food groups. (thepaleodiet.com)
  • The concentrations of TF and PAI‑1 in culture supernatant were also measured by ELISA. (spandidos-publications.com)
  • These studies have consistently shown, on the basis of hierarchical clustering of gene expression profiles, that ER-positive breast cancers can be classified into molecular subtypes (mainly luminal A and B) and that these subtypes are associated with a different clinical outcome, suggesting a molecular basis behind the clinical heterogeneity. (biomedcentral.com)
  • While there are relatively few studies examining epigenetically mediated mechanisms involved in visceral nociception, stress-induced visceral pain has been linked to alterations in DNA methylation and histone acetylation patterns within the brain, leading to increased expression of pro-nociceptive neurotransmitters. (frontiersin.org)
  • The role of two members of the ETS (E26 avian leukemia oncogene) family of transcription factors, ETS-1 and ETS-2, has been investigated in many cancers but has not yet been studied in ocular tumors. (molvis.org)
  • We determined the expression of components of the ECS in the human fetal testis from 6 to 17 developmental weeks and assessed the direct effects of phytocannabinoids Δ9-trans-tetrahydrocannabinol (THC) and cannabidiol (CBD) on the testis morphology and cell functions ex vivo. (biomedcentral.com)
  • Ex vivo exposure of first trimester testes to CBD, THC, or CBD/THC [ratio 1:1] at 10 −7 to 10 −5 M altered testosterone secretion by Leydig cells, AMH secretion by Sertoli cells, and impacted testicular cell proliferation and viability as early as 72 h post-exposure. (biomedcentral.com)
  • We demonstrate the presence in the human fetal testis of two key endocannabinoids, 2-arachidonylglycerol (2-AG) and to a lower level anandamide (AEA), as well as a range of enzymes and receptors for the ECS. (biomedcentral.com)
  • 289 transcripts altered in expression following APC loss in human cells were linked to APC-associated genomic regions. (duke.edu)
  • Type 1 Cytotoxic T Cells Increase in Placenta after Intrauterine Inflammation. (umaryland.edu)
  • Undifferentiated mesenchymal stem cells are pluripotent cells that can differentiate into various phenotypes and are a source of osteogenic Cells 1,2 . (bvsalud.org)
  • EDIL3 has also been shown to be an endogenous inhibitor of inflammatory cell recruitment by interfering with the integrin LFA-1-dependent leukocyte-endothelial adhesion. (rndsystems.com)
  • Here, we set out to study the relationship between S1P and CFTR expression in the HF lung. (lu.se)
  • The Centers for Disease Control and Prevention's (CDC) National Notifiable Diseases Surveillance System (NNDSS) ( 1 ) receives viral hepatitis case reports electronically each week from state and territorial health departments in the United States (U.S.) via CDC's National Electronic Telecommunications System for Surveillance (NETSS), a computerized public health surveillance system. (cdc.gov)
  • Both provisions also target expression for restriction on the basis of its content. (techdirt.com)
  • Visual impairment is common, affecting between 2.8% and 10% of patients, 1 - 3 and may result directly from damage to uveal tract structures, or may occur due to secondary effects on neighboring tissues: for example, accelerated cataract formation, glaucoma, and macular edema. (dovepress.com)
  • We generated gene expression profiles (Affymetrix) and computed the GGI for a matched, case-control sample of patients enrolled in the BIG 1-98 trial from the two hospitals where frozen samples were available. (biomedcentral.com)
  • A mouse microglial cell line was treated with medium or organic dust extract (ODE, 1% v/v) along with either phosphate-buffered saline (PBS) or mitoapocynin (MA, 10 µmol). (cdc.gov)
  • Long-distance training results in a switch of muscle type expression to type I, which supports endurance. (brainmass.com)
  • 1) reported the results of a genome-wide association study (GWAS) of resistance to stripe rust in a large collection of hexaploid spring wheat cultivars in six different environments in the western USA. (ucdavis.edu)
  • Cannabis action is mediated by the endocannabinoid system (ECS), which expression is well established in the brain but unknown in the developing testis. (biomedcentral.com)
  • Motif analysis and comparison to ChIP-seq datasets for other transcription factors identified a prevalence of binding sites for the TCF7L2 and AP-1 transcription factors in APC-associated genomic regions. (duke.edu)
  • [ 1 ] Macrophages phagocytose debris and bacteria. (medscape.com)
  • We of both mitogen- and Ag-induced accessory cell-dependent T lym- phocyte proliferation. (cdc.gov)
  • G substitution at aa 66 and a deletion of aa 67-76 found in isoform 1. (rndsystems.com)