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Cyclin D1Cyclin-Dependent KinasesCyclin-Dependent Kinase 4Cyclin-Dependent Kinase 5Cyclin-Dependent Kinase 2Cyclin D2Cyclin DCyclinsCDC2-CDC28 KinasesCyclin D3Cyclin-Dependent Kinase 6CDC2 Protein KinaseCell CycleCyclin-Dependent Kinase 9Genes, bcl-1Cell Cycle ProteinsG1 PhaseChromosomes, Human, Pair 11Gene AmplificationCyclin ECyclin-Dependent Kinase Inhibitor p27PhosphorylationProtein-Serine-Threonine KinasesLymphoma, Mantle-CellKinetinCyclin-Dependent Kinase 8Diagnostic Techniques, RadioisotopeS PhaseCell Line, TumorOncogene ProteinsIn Situ Hybridization, FluorescenceCyclin-Dependent Kinase Inhibitor p16Cyclin-Dependent Kinase Inhibitor p21Proto-Oncogene ProteinsPurinesCyclin HGene Expression Regulation, NeoplasticCell ProliferationCyclin BTumor Suppressor ProteinsMitosisCyclin-Dependent Kinase Inhibitor p18Translocation, GeneticCyclin-Dependent Kinase 3Genes, mycCyclin TFibroblast Growth Factor 3Cyclin CCyclin B1cdc25 PhosphatasesChromosomes, Human, Pair 14Gene Expression ProfilingRNA, MessengerBreast NeoplasmsCell Cycle CheckpointsCortactinProto-Oncogene Proteins c-mycMicrotubule-Associated ProteinsGenes, cdcCyclin-Dependent Kinase Inhibitor ProteinsDown-RegulationReverse Transcriptase Polymerase Chain ReactionMutationOligonucleotide Array Sequence AnalysisNuclear ProteinsSignal TransductionProtein BindingCell DivisionApoptosisCell LineMolecular Sequence DataG2 PhaseEnzyme InhibitorsRNA InterferenceGene DosageRNA, Small InterferingDNA, NeoplasmCarcinoma, Squamous CellGenes, erbB-2Positive Transcriptional Elongation Factor BPolymorphism, GeneticCell NucleusHeLa CellsGene Expression RegulationComparative Genomic HybridizationProlactinomaDNA PrimersCells, CulturedTechnetium CompoundsTumor Cells, CulturedGenes, p16Enzyme ActivationSOXC Transcription FactorsThreonineTransfectionTranscription, GeneticGenotypeTranscription FactorsCell Transformation, NeoplasticTumor Suppressor Protein p53
2023Cancer
20233
Cancer1
  • Amplification of the CCND1 gene is present in: non-small cell lung cancers (30-46%) head and neck squamous cell carcinomas (30-50%) pancreatic carcinomas (25%) bladder cancer (15%) pituitary adenomas (49-54%) breast carcinoma (13%) Cyclin D1 overexpression is strongly correlated to ER+ breast cancer and deregulation of cyclin D1 is associated with hormone therapy resistance in breast cancer. (wikipedia.org)