Inbred rats derived from Sprague-Dawley rats and used for the study of salt-dependent hypertension. Salt-sensitive and salt-resistant strains have been selectively bred to show the opposite genetically determined blood pressure responses to excess sodium chloride ingestion.

Sodium chloride used in foods.

A ubiquitous sodium salt that is commonly used to season food.

Animals that are produced through selective breeding to eliminate genetic background differences except for a single or few specific loci. They are used to investigate the contribution of genetic background differences to PHENOTYPE.

A diet which contains very little sodium chloride. It is prescribed by some for hypertension and for edematous states. (Dorland, 27th ed)

Sodium or sodium compounds used in foods or as a food. The most frequently used compounds are sodium chloride or sodium glutamate.

Persistently high systemic arterial BLOOD PRESSURE. Based on multiple readings (BLOOD PRESSURE DETERMINATION), hypertension is currently defined as when SYSTOLIC PRESSURE is consistently greater than 140 mm Hg or when DIASTOLIC PRESSURE is consistently 90 mm Hg or more.

PRESSURE of the BLOOD on the ARTERIES and other BLOOD VESSELS.

Inbreed BN (Brown Norway) rats are a strain of laboratory rats that are specifically bred for research purposes, characterized by their uniform genetic makeup and susceptibility to various diseases, which makes them ideal models for studying human physiology and pathophysiology.

Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.

A P450 oxidoreductase that catalyzes the hydroxylation of the terminal carbon of linear hydrocarbons such as octane and FATTY ACIDS in the omega position. The enzyme may also play a role in the oxidation of a variety of structurally unrelated compounds such as XENOBIOTICS, and STEROIDS.

An alpha-2 selective adrenergic agonist used as an antihypertensive agent.

Genetically identical individuals developed from brother and sister matings which have been carried out for twenty or more generations or by parent x offspring matings carried out with certain restrictions. This also includes animals with a long history of closed colony breeding.

The internal portion of the kidney, consisting of striated conical masses, the renal pyramids, whose bases are adjacent to the cortex and whose apices form prominent papillae projecting into the lumen of the minor calyces.

Rats bearing mutant genes which are phenotypically expressed in the animals.

Loose heterogeneous collection of cells in the anterior hypothalamus, continuous rostrally with the medial and lateral PREOPTIC AREAS and caudally with the TUBER CINEREUM.