Oceanic Ancestry Group
American Native Continental Ancestry Group
African Continental Ancestry Group
European Continental Ancestry Group
Individuals whose ancestral origins are in the continent of Europe.
Asian Continental Ancestry Group
Polymorphism, Single Nucleotide
Genome-Wide Association Study
The genetic constitution of the individual, comprising the ALLELES present at each GENETIC LOCUS.
Indians, South American
Individual members of South American ethnic groups with historic ancestral origins in Asia.
The proportion of one particular in the total of all ALLELES for one genetic locus in a breeding POPULATION.
Genetic Predisposition to Disease
Trinidad and Tobago
An independent state in the Lesser Antilles in the West Indies, north of Venezuela, comprising the islands of Trinidad and Tobago. Its capital is Port of Spain. Both islands were discovered by Columbus in 1498. The Spanish, English, Dutch, and French figure in their history over four centuries. Trinidad and Tobago united in 1898 and were made part of the British colony of Trinidad and Tobago in 1899. The colony became an independent state in 1962. Trinidad was so named by Columbus either because he arrived on Trinity Sunday or because three mountain peaks suggested the Holy Trinity. Tobago was given the name by Columbus from the Haitian tambaku, pipe, from the natives' habit of smoking tobacco leaves. (Webster's New Geographical Dictionary, 1988, p1228, 1216 & Room, Brewer's Dictionary of Names, 1992, p555, 547)
Specific regions that are mapped within a GENOME. Genetic loci are usually identified with a shorthand notation that indicates the chromosome number and the position of a specific band along the P or Q arm of the chromosome where they are found. For example the locus 6p21 is found within band 21 of the P-arm of CHROMOSOME 6. Many well known genetic loci are also known by common names that are associated with a genetic function or HEREDITARY DISEASE.
Nonrandom association of linked genes. This is the tendency of the alleles of two separate but already linked loci to be found together more frequently than would be expected by chance alone.
Principal Component Analysis
A coordinated international effort to identify and catalog patterns of linked variations (HAPLOTYPES) found in the human genome across the entire human population.
Chromosomes, Human, Y
Genetic Association Studies
A phenomenon that is observed when a small subgroup of a larger POPULATION establishes itself as a separate and isolated entity. The subgroup's GENE POOL carries only a fraction of the genetic diversity of the parental population resulting in an increased frequency of certain diseases in the subgroup, especially those diseases known to be autosomal recessive.
A chromosome disorder associated either with an extra chromosome 21 or an effective trisomy for chromosome 21. Clinical manifestations include hypotonia, short stature, brachycephaly, upslanting palpebral fissures, epicanthus, Brushfield spots on the iris, protruding tongue, small ears, short, broad hands, fifth finger clinodactyly, Simian crease, and moderate to severe INTELLECTUAL DISABILITY. Cardiac and gastrointestinal malformations, a marked increase in the incidence of LEUKEMIA, and the early onset of ALZHEIMER DISEASE are also associated with this condition. Pathologic features include the development of NEUROFIBRILLARY TANGLES in neurons and the deposition of AMYLOID BETA-PROTEIN, similar to the pathology of ALZHEIMER DISEASE. (Menkes, Textbook of Child Neurology, 5th ed, p213)
Chromosomes, Human, Pair 21
A genus of gram-negative, aerobic bacteria occurring as rods (subgenus Moraxella) or cocci (subgenus Branhamella). Its organisms are parasitic on the mucous membranes of humans and other warm-blooded animals.