No-Observed-Adverse-Effect Level: The highest dosage administered that does not produce toxic effects.Toxicity Tests, Subchronic: Experiments designed to determine the potential toxic effects of mid-term (a few months) exposure to a chemical or chemicals.Toxicity Tests, Chronic: Experiments designed to determine the potential toxic effects of a long-term exposure to a chemical or chemicals.Toxicity Tests, Acute: Experiments designed to determine the potential toxic effects of one-time, short-term exposure to a chemical or chemicals.Toxicity Tests: An array of tests used to determine the toxicity of a substance to living systems. These include tests on clinical drugs, foods, and environmental pollutants.Organ Size: The measurement of an organ in volume, mass, or heaviness.Dose-Response Relationship, Drug: The relationship between the dose of an administered drug and the response of the organism to the drug.Body Weight: The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.Administration, Oral: The giving of drugs, chemicals, or other substances by mouth.Eating: The consumption of edible substances.Rats, Sprague-Dawley: A strain of albino rat used widely for experimental purposes because of its calmness and ease of handling. It was developed by the Sprague-Dawley Animal Company.Abnormalities, Drug-Induced: Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment.Benzhydryl Compounds: Compounds which contain the methyl radical substituted with two benzene rings. Permitted are any substituents, but ring fusion to any of the benzene rings is not allowed.Toxicology: The science concerned with the detection, chemical composition, and biological action of toxic substances or poisons and the treatment and prevention of toxic manifestations.Phenols: Benzene derivatives that include one or more hydroxyl groups attached to the ring structure.Rats, Inbred F344Reproduction: The total process by which organisms produce offspring. (Stedman, 25th ed)Prenatal Exposure Delayed Effects: The consequences of exposing the FETUS in utero to certain factors, such as NUTRITION PHYSIOLOGICAL PHENOMENA; PHYSIOLOGICAL STRESS; DRUGS; RADIATION; and other physical or chemical factors. These consequences are observed later in the offspring after BIRTH.Environmental Exposure: The exposure to potentially harmful chemical, physical, or biological agents in the environment or to environmental factors that may include ionizing radiation, pathogenic organisms, or toxic chemicals.Occupational Exposure: The exposure to potentially harmful chemical, physical, or biological agents that occurs as a result of one's occupation.Pregnancy: The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.