HMGB1 Protein: A 24-kDa HMGB protein that binds to and distorts the minor grove of DNA.HMGB2 Protein: A 23-kDa HMG-box protein that binds to and distorts the minor grove of DNA.HMGB3 Protein: An HMG-box domain (HMG-BOX DOMAINS) found highly expressed in embryonic tissue and in placenta.HMGB Proteins: A family of sequence-related proteins similar to HMGB1 PROTEIN that contains specific HMG-BOX DOMAINS.HMG-Box Domains: DNA-binding domains present in proteins of the HMG-box superfamily including the archetypal HMGB PROTEINS, a number of sequence specific TRANSCRIPTION FACTORS, and other DNA-BINDING PROTEINS. The domains consist of 70-80 amino acids that form an L-shaped fold from three alpha-helical segments. The domain has the capacity to recognize and/or induce specific DNA structures and effect the accessibility of the DNA to other proteins involved in transcription, recombination, or DNA repair. (Note that not all HIGH MOBILITY GROUP PROTEINS contain this domain.)Toll-Like Receptor 4: A pattern recognition receptor that interacts with LYMPHOCYTE ANTIGEN 96 and LIPOPOLYSACCHARIDES. It mediates cellular responses to GRAM-NEGATIVE BACTERIA.