A major affective disorder marked by severe mood swings (manic or major depressive episodes) and a tendency to remission and recurrence.
Works containing information articles on subjects in every field of knowledge, usually arranged in alphabetical order, or a similar work limited to a special field or subject. (From The ALA Glossary of Library and Information Science, 1983)
Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of thought, feeling, and behavior producing either distress or impairment of function.
Disorders related to substance abuse.
An element in the alkali metals family. It has the atomic symbol Li, atomic number 3, and atomic weight [6.938; 6.997]. Salts of lithium are used in treating BIPOLAR DISORDER.
Persistent and disabling ANXIETY.
Agents that are used to treat bipolar disorders or mania associated with other affective disorders.
Marked depression appearing in the involution period and characterized by hallucinations, delusions, paranoia, and agitation.
Inorganic compounds that contain lithium as an integral part of the molecule.
Those disorders that have a disturbance in mood as their predominant feature.
An affective disorder manifested by either a dysphoric mood or loss of interest or pleasure in usual activities. The mood disturbance is prominent and relatively persistent.
Categorical classification of MENTAL DISORDERS based on criteria sets with defining features. It is produced by the American Psychiatric Association. (DSM-IV, page xxii)
Abnormal or excessive excitability with easily triggered anger, annoyance, or impatience.
Depressive states usually of moderate intensity in contrast with major depression present in neurotic and psychotic disorders.
Standardized procedures utilizing rating scales or interview schedules carried out by health personnel for evaluating the degree of mental illness.
An analysis comparing the allele frequencies of all available (or a whole GENOME representative set of) polymorphic markers in unrelated patients with a specific symptom or disease condition, and those of healthy controls to identify markers associated with a specific disease or condition.
A single nucleotide variation in a genetic sequence that occurs at appreciable frequency in the population.
A severe emotional disorder of psychotic depth characteristically marked by a retreat from reality with delusion formation, HALLUCINATIONS, emotional disharmony, and regressive behavior.
That part of the genome that corresponds to the complete complement of EXONS of an organism or cell.
Voltage-dependent cell membrane glycoproteins selectively permeable to calcium ions. They are categorized as L-, T-, N-, P-, Q-, and R-types based on the activation and inactivation kinetics, ion specificity, and sensitivity to drugs and toxins. The L- and T-types are present throughout the cardiovascular and central nervous systems and the N-, P-, Q-, & R-types are located in neuronal tissue.
A latent susceptibility to disease at the genetic level, which may be activated under certain conditions.