A geographical area of the United States with no definite boundaries but comprising northeastern Alabama, northwestern Georgia, northwestern South Carolina, western North Carolina, eastern Kentucky, eastern Tennessee, western Virginia, West Virginia, western Maryland, southwestern Pennsylvania, southern Ohio, and southern New York.

#### My apologies, but "West Virginia" is a geographical location and not a medical term or condition. It is a state located in the Appalachian region of the United States, known for its diverse topography, rich cultural history, and contributions to various fields including medicine.