Simultaneous determination of albendazole and praziquantel by second derivative spectrophotometry and multivariated calibration methods in veterinary pharmaceutical formulation.
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The simultaneous determination of albendazole (ABZ) and praziquantel (PZQ) was performed by different mathematical approaches: second derivative spectrophotometry (SDS), classical least squares, regression of partial least squares and principal components regression based on spectral data of drugs dissolved in methanol-hydrochloric acid solution. The detection limits for multivariate calibrations were determined by creating a surrogate variable signal. SDS presented the best analytical features. The recoveries of ABZ and PZQ from the synthetic samples were near to 100 +/- 5%. The methods were applied in veterinary pharmaceutical formulation whose mass ratio ABZ:PZQ is 10:1; the results obtained were according to nominal content. (+info)
Determination of active substances in multicomponent veterinary preparations of antiparasitic action by HPLC method.
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The study aimed at the development of an HPLC method enabling the identification and determination of the content of selected compounds occurring in multicomponent veterinary preparations used in parasitic diseases. The studied compounds included: pyrantel embonate, fenbendazole, praziquantel, epsiprantel and febantel. Using the developed HPLC method, a good separation of the above compounds was achieved. The regression analysis has shown linearity of the method in the required concentration range. The determination of the compounds mentioned and statistical evaluation of the results have demonstrated that the method is characterized by a good selectivity and high precision. (+info)
Dose imprecision and resistance: free-choice medicated feeds in industrial food animal production in the United States.
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