TyrosineSerinePhosphorylationAmino Acid SequenceMolecular Sequence DataMutagenesis, Site-DirectedBinding SitesCell LinePhosphoserineProtein BindingKineticsMutationPhosphotyrosinePhosphoproteinsEnzyme ActivationProtein Structure, TertiaryProtein KinasesProtein Tyrosine PhosphatasesBase SequenceRecombinant ProteinsModels, MolecularSequence Homology, Amino AcidProtein-Serine-Threonine KinasesThreonineSignal TransductionSubstrate SpecificityProtein ConformationProtein-Tyrosine KinasesAmino Acid SubstitutionPeptide MappingPhosphopeptidesTetranitromethaneTransfectionPeptide FragmentsStructure-Activity RelationshipRecombinant Fusion ProteinsProtein Processing, Post-TranslationalSerine EndopeptidasesCells, CulturedAmino AcidsCOS CellsEnzyme InhibitorsElectrophoresis, Polyacrylamide GelProteinsCloning, MolecularTyrosine 3-MonooxygenaseSequence AlignmentProtein Kinase CAmino Acid MotifsProto-Oncogene ProteinsBlotting, WesternEscherichia coliPeptidesPrecipitin TestsProtein Structure, SecondaryMolecular WeightIntracellular Signaling Peptides and ProteinsCysteineCyclic AMP-Dependent Protein KinasesDNA-Binding ProteinsMembrane ProteinsCasein Kinase IITrypsinCatalysisPhosphothreonineCell MembraneAdaptor Proteins, Signal TransducingCattlePoint Mutationsrc Homology DomainsCatalytic DomainImmunoblottingMitogen-Activated Protein KinasesAlanineConserved SequenceOxidative PhosphorylationCalcium-Calmodulin-Dependent Protein KinasesHeLa Cellssrc-Family KinasesCarrier Proteins3T3 CellsCricetinaeDNA PrimersPhosphoprotein PhosphatasesVanadatesIsoenzymesProtein Tyrosine Phosphatase, Non-Receptor Type 11CytoplasmHistidinePhosphatidylinositol 3-KinasesTumor Cells, CulturedMutagenesisCalciumHydrogen-Ion ConcentrationImmunoprecipitationChromatography, High Pressure LiquidDNAProto-Oncogene Proteins c-aktCrystallography, X-RayMass Spectrometry