Taste change associated with a dental procedure: case report and review of the literature.
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Loss or alteration of taste is a rare phenomenon that may be idiopathic or may be caused by head trauma, medication use or systemic and local factors including various invasive dental procedures resulting in nerve damage. We present an unusual case of generalized taste change following an oral surgical procedure. The case is presented to enhance understanding of taste disorders and their relation to a localized traumatic event. Causative factors and management strategies are also reviewed. (+info)
Burning mouth disorder (BMD) and taste: a hypothesis.
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BACKGROUND: Burning mouth disorder (BMD) is a burning or stinging sensation affecting the oral mucosa, lips, and/or tongue, in the absence of clinically visible mucosal lesions. There is a strong female predilection, with the age of onset being approximately 50 years. The causes of BMD are multifactorial and remain poorly understood. Often BMD patients report, in association, change in taste. In this regards, it is relevant that in central nervous system connections exist between taste and oral pain and that taste normally inhibits oral pain. AIM: The working hypothesis of this study considers a possible relationship between burning mouth disorders and alterations of taste. Several conditions or pathologies can be responsible of taste disturbances that might be the cause of oral pain in BMD patients. SUBJECTS AND METHODS: We have analyzed, retrospectively, 142 cases of BMD with associated taste disturbance. Possible causes that could be responsible for alterations of taste were investigated. RESULTS AND CONCLUSIONS: Sixty-one subjects revealed the habitual use of drugs having a documented interference with taste perception. Thirty-five subjects, among the 81 patients who had no associated pathology or habitual use of drugs, noticed in their clinical history conditions, pathologies or use of drugs that are known to affect the gustatory system. Therefore, we propose that BMD may represent an oral phantom pain induced in susceptible individuals by alteration of taste. (+info)
Relation between drug-induced taste disorder and chelating behavior with zinc ion; statistical approach to the drug-induced taste disorder, part II.
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There are many reports that the drug-induced taste disorder is ascribable to the chelate reaction of a drug with zinc ion and the following zinc deficiency. As a quantitative measure of the chelating ability of drugs with zinc ions, the chelating ability was estimated from the electrode potential change of the Zn2+/Zn(Hg) system during the addition of a drug. The electrode potential was measured in a water-N,N-dimethylformamide mixed solution and in an aqueous solution depending on the solubility of the drugs. The observed electrode potential change showed a positive correlation to the frequency of the drug-induced taste disorder that was supplied from the manufacturer of the original drug. The regression analysis was carried out assuming that the frequency of the taste disorder and the electrode potential change was linear. The F-values, p-values, and R2-values were 4.29, 0.13, 0.589, and 4.15, 0.13, 0.580, respectively. The positive correlation between the drug-induced taste disorder and the electrode potential change appeared evident if the uncertainty in the frequency of the taste disorder was taken into consideration. Thus the assumption of the zinc ion chelating mechanism on the drug-induced disorder was also evident except for cisplatin. The frequency of the drug-induced taste disorder of bezafibrate was estimated to be 0.4--0.5 from the regression analysis. (+info)
Self-care strategies to cope with taste changes after chemotherapy.
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Qualitative and quantitative assessment of taste and smell changes in patients undergoing chemotherapy for breast cancer or gynecologic malignancies.
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