Metallo-intercalators and metallo-insertors.
(57/243)Since the elucidation of the structure of double helical DNA, the construction of small molecules that recognize and react at specific DNA sites has been an area of considerable interest. In particular, the study of transition metal complexes that bind DNA with specificity has been a burgeoning field. This growth has been due in large part to the useful properties of metal complexes, which possess a wide array of photophysical attributes and allow for the modular assembly of an ensemble of recognition elements. Here we review recent experiments in our laboratory aimed at the design and study of octahedral metal complexes that bind DNA non-covalently and target reactions to specific sites. Emphasis is placed both on the variety of methods employed to confer site-specificity and upon the many applications for these complexes. Particular attention is given to the family of complexes recently designed that target single base mismatches in duplex DNA through metallo-insertion. (+info)
Immobilization of chiral ferrocenyl ligands on silica gel and their testing in Pd-catalyzed allylic substitution and Rh-catalyzed hydrogenation.
(58/243)Five different silica gels containing two chiral ferrocenyl ligands were prepared by various synthetic routes and tested in an enantioselective Pd(0)-catalyzed allylic substitution and Rh-catalyzed hydrogenation. All the prepared anchored ligands were characterized by porosimetry data, DRIFTS spectra, thermal data and AAS. The aim of the work was to compare the influence of the carrier, surface properties and immobilization strategy on the performance of the catalyst. (+info)
Optimal TBHP allylic oxidation of Delta5-steroids catalyzed by dirhodium caprolactamate.
(59/243)Dirhodium caprolactamate is the most efficient catalyst for the oxidation of Delta5-steroids to 7-keto-Delta5-steroids by 70% tert-butyl hydroperoxide in water (T-HYDRO). Isolated product yields range from 38 to 87%. (+info)
Binding effect of the antitumor active dirhodium (II) compounds to plasmid DNA.
(60/243)Binding effect of the antitumor dirhodium (II) compounds to the plasmid pUC19 DNA has been studied under different molar ratio of Rh (II) compounds to base pair of pUC19 DNA (Rf) and time. The electrophoresis results indicate that Rh binding affect the DNA conformation and therefore, Rh-DNA migrated in the different position comparing with native DNA. At high value of Rf ICP-MS (Inductively Coupled Plasma Mass Spectrometry) measurement confirmed that 46% of Rh binds to DNA. In vitro result shows that DNA synthesis was inhibited by the Rh binding. (+info)
Rh(I)-catalyzed arylation of heterocycles via C-H bond activation: expanded scope through mechanistic insight.
Diastereo- and enantioselective hydrogenative aldol coupling of vinyl ketones: design of effective monodentate TADDOL-like phosphonite ligands.
Asymmetric synthesis of (-)-incarvillateine employing an intramolecular alkylation via Rh-catalyzed olefinic C-H bond activation.
Rhodium(I)-catalyzed cycloisomerizations of bicyclobutanes.