Thallium-201 for medical use. II: Biologic behavior.
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Thallium-201 has been evaluated for myocardial imaging by determining its distribution and assessing its imaging properties. Organ distribution with time was studied in goats, chosen for their large size and easy operability. Myocardial imaging was performed in living and sacrificed goats and also in two anesthetized dogs, without infarction. Infarcts were made by ligature at open chest surgery on the goats and the infarcts subsequently confirmed histologically. The myocardium of normal and infarced, young and old goats was cut into blocks and the isotope distribution measured and compared with that in the lungs, liver, spleen, and kidney in normal goats. The renal medulla-to-cortex concentration ratio in goats was studied and is approximately five. The heart uptake exceeds 3% for 100 min whereas contiguous organs have less than one-half of the myocardial concentration, and blood clearance is rapid. One problem may prove to be inhomogeneity of uptake of thallium in the "normal" myocardium, showing a standard deviation of 1u% in a young goat and 29% in an old goat. In view of the good myocardial uptake, however, this work strongly suggests the trial 201Tl in patients. (+info)
Chemical and biologic properties of 111In-phosphate for cisternography and glomerular filtration studies.
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Inorganic 111In-phosphate has been evaluated for cisternography in dogs, rats, and one human volunteer for chemical and biologic stability and renal clearance. It appears to be stable and to be completely cleared by glomerular filtration, suggesting its suitability for cisternography. (+info)
Diminished uptake of 67Ga-citrate in a case of pseudarthrosis.
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A 22-year-old man with pseudarthrosis and infection of the right hip was referred for a 67Ga-citrate scan. A striking decrease was seen in normal bone and soft-tissue uptake in the entire right leg compared with the normal limb. Aortic injection of 99mTc-labeled microspheres showed increased trapping in the region of the hip but contrast angiography was unremarkable. Despite clinical imporvement, 67Ga uptake by the right leg on a repeat scan did not return to normal. This case represents the first report of a "photon-deficient" body part on 67Ga scanning. (+info)
Pulmonary blood flow distribution after banding of pulmonary artery.
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Radioisotope lung scanning was used to investigate the distribution of pulmonary blood flow after banding of the pulmonary artery in children with a left-to-right shunt and pulmonary hypertension. An abnormal distribution of blood flow in the lung on the side of the operation approach was observed in all patients in the first three weeks following surgery. Abnormalities were still observed in 17 of 21 children 10 months to more than 8 years after the banding operation. There was no significant relation between the occurrence of these abnormalities and time after surgery. Diminished flow to the zones of the right lung was observed less frequently. The incidence of abnormalities in flow distribution was also high preoperatively. Respiratory complications in infants with large left-to-right shunts were considered to be responsible for most of the abnormal blood flow distributions observed. Radioactive lung scanning was found to be a valuable diagnostic method in the early and late postoperative period in infants and small children. It was more sensitive than the other techniques used in revealing deviation of blood flow from one lung in those cases with shifting of the applied band. (+info)
Pulmonary arteriovenous malformation: scintigraphic demonstration and analysis.
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Scintiphotographic demonstration of a pulmonary arteriovenous malformation in an 8-year-old child is presented. Using a data processor, the transit of radiopertechnetate through the lesion as well as various portions of the lung is shown. The "steal" of blood flow from the left lobe is documented. (+info)
Initial clinical experiences with a Fresnel zone-plate imager.
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First clinical studies with a Fresnel zone-plate radioisotope imager demonstrate high resolution, sharp tomography, and freedom from scatter. Improved radionuclide imaging is demonstrated, at least for small organs like the thyroid. Certain limitations are present that indicate a need for additional development before application to routine clinical practice. (+info)
Changes in 87mSr concentractions in skeletal metastases in patients responding to cyclical combination chemotherapy for advanced breast cancer.
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Serial 87mSr bone scintigrams were performed on a series of patients being treated by cyclical combination chemotherapy for metastatic breast cancer. All the patients investigated responeded to the chemotherapy, but initially the scintigrams showed an apparent deterioration, in that the tumor-to-normal isotope uptake ratios increased. Following this initial "flare" the scintigram appearance improved with a decrease in the tumor-to-normal uptake ratio. It is suggested that deterioration in the scintigram in the early stages of treatment should not be regarded as an indication that the patient is failing to respond. (+info)
Changes in liver scan following splenectomy.
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Changes in liver shape, position, and uptake of colloid have been noted by us in liver scans in patients following splenectomy. These changes have resulted in confusion in interpretation. Four cases are described to illustrate some of the possible misinterpretations. These include migration of the left lobe of the liver into the left upper quadrant mimicking residual or accessory spleen, mass lesion in the region of the porta hepatis, or recurrent foci of disease. (+info)