Latin as the language of medical terminology: some remarks on its role and prospects. (17/351)

The present paper offers an up-to-date view of the status of Latin as the language of medicine, namely in its terminological component. It is concerned in greater detail with the three basic terminological vocabularies in which a doctor cannot so far manage without its knowledge. In this sense a primary rank is occupied by anatomical nomenclature whose international version remains Latin in the full extent. A more varied picture is presented by the clinical disciplines where, apart from Latin terms, expressions of ancient provenance have been applied in a large measure in the form of ethnic languages. At the same time, particularly in view of the needs of computerisation, repeated attempts have appeared to support English, which has the greatest chance of becoming a new language in the particular region of clinical medicine. In pharmaceutical terminology Latin has, for the time being, remained a functioning means of international communication, guaranteed by the European Pharmacopoeia (1996) and by the corpus of International Non-proprietary Names (1992, 1996), even though in the future an ever stronger competition of national languages should be taken into account.  (+info)

Publications in epidemiology journals: Japanese perspectives. (18/351)

This paper presents information on Japan's contribution to reputable epidemiologic journals as compared to other leading countries. Ten journals in the field of epidemiology with high impact factors were selected. Articles published in these journals during the period between 1991 and 2000 were searched for the authors' affiliation using Medline database. We found that Japan contributed only 1.1% of the total number of articles published and ranked 14th among all the countries. The United States of America contributed 56.3% of the total and ranked top followed by the United Kingdom (7.6%), Canada (4.1%), and the Netherlands (3.5%). In a time trend analysis, Japan's share of articles did not increase significantly in the last decade (p = 0.41). Barriers in conducting epidemiologic research in Japan should be identified and appropriate measures should be taken accordingly.  (+info)

Evaluation of informative materials on leishmaniasis distributed in Brazil: criteria and basis for the production and improvement of health education materials. (19/351)

Based on categories related to structure, content, language, and illustrations, the present study provides an evaluation of the quality of educational materials on leishmaniasis available to health services in Brazil. The 18 publications evaluated consisted of four handbooks, four guided studies, four booklets, and six leaflets. Of the total publications assessed, nine were produced by the Brazilian National Health Foundation (FUNASA), five by State and Municipal Health Departments jointly with FUNASA, and one by the Pan-American Health Organization. The evaluations were also performed by three professionals: a physician specialized in leishmaniasis, a parasitologist, and an information/communications expert. The publications failed to specify key items such as target public, objective, and bibliography. The illustrations, especially in the booklets and leaflets, failed to clarify the text, portrayed biased concepts, and omitted credits and scale. According to this study, informative materials on leishmaniasis distributed in Brazil present major limitations which jeopardize the quality of information they contain.  (+info)

Rumbles and grumbles from around the world. (20/351)

A different kind of shake-up will hit the science establishment when the New Year dawns in earthquake-prone Japan, reports Nature in its lead story this week. Science kicks off self-referentially with a lead story about its decision to publish a paper on sequencing the human genome from Craig Venter of Celera Genomics.  (+info)

Fluorescence in situ hybridization: past, present and future. (21/351)

Fluorescence in situ hybridization (FISH), the assay of choice for localization of specific nucleic acids sequences in native context, is a 20-year-old technology that has developed continuously. Over its maturation, various methodologies and modifications have been introduced to optimize the detection of DNA and RNA. The pervasiveness of this technique is largely because of its wide variety of applications and the relative ease of implementation and performance of in situ studies. Although the basic principles of FISH have remained unchanged, high-sensitivity detection, simultaneous assay of multiple species, and automated data collection and analysis have advanced the field significantly. The introduction of FISH surpassed previously available technology to become a foremost biological assay. Key methodological advances have allowed facile preparation of low-noise hybridization probes, and technological breakthroughs now permit multi-target visualization and quantitative analysis - both factors that have made FISH accessible to all and applicable to any investigation of nucleic acids. In the future, this technique is likely to have significant further impact on live-cell imaging and on medical diagnostics.  (+info)

The computational analysis of scientific literature to define and recognize gene expression clusters. (22/351)

A limitation of many gene expression analytic approaches is that they do not incorporate comprehensive background knowledge about the genes into the analysis. We present a computational method that leverages the peer-reviewed literature in the automatic analysis of gene expression data sets. Including the literature in the analysis of gene expression data offers an opportunity to incorporate functional information about the genes when defining expression clusters. We have created a method that associates gene expression profiles with known biological functions. Our method has two steps. First, we apply hierarchical clustering to the given gene expression data set. Secondly, we use text from abstracts about genes to (i) resolve hierarchical cluster boundaries to optimize the functional coherence of the clusters and (ii) recognize those clusters that are most functionally coherent. In the case where a gene has not been investigated and therefore lacks primary literature, articles about well-studied homologous genes are added as references. We apply our method to two large gene expression data sets with different properties. The first contains measurements for a subset of well-studied Saccharomyces cerevisiae genes with multiple literature references, and the second contains newly discovered genes in Drosophila melanogaster; many have no literature references at all. In both cases, we are able to rapidly define and identify the biologically relevant gene expression profiles without manual intervention. In both cases, we identified novel clusters that were not noted by the original investigators.  (+info)

Methodology in diagnostic laboratory test research in clinical chemistry and clinical chemistry and laboratory medicine. (23/351)

BACKGROUND: The application of epidemiologic principles to clinical diagnosis has been less developed than in other clinical areas. Knowledge of the main flaws affecting diagnostic laboratory test research is the first step for improving its quality. We assessed the methodologic aspects of articles on laboratory tests. METHODS: We included articles that estimated indexes of diagnostic accuracy (sensitivity and specificity) and were published in Clinical Chemistry or Clinical Chemistry and Laboratory Medicine in 1996, 2001, and 2002. Clinical Chemistry has paid special attention to this field of research since 1996 by publishing recommendations, checklists, and reviews. Articles were identified through electronic searches in Medline. The strategy combined the Mesh term "sensitivity and specificity" (exploded) with the text words "specificity", "false negative", and "accuracy". We examined adherence to seven methodologic criteria used in the study by Reid et al. (JAMA1995;274:645-51) of papers published in general medical journals. Three observers evaluated each article independently. RESULTS: Seventy-nine articles fulfilled the inclusion criteria. The percentage of studies that satisfied each criterion improved from 1996 to 2002. Substantial improvement was observed in reporting of the statistical uncertainty of indices of diagnostic accuracy, in criteria based on clinical information from the study population (spectrum composition), and in avoidance of workup bias. Analytical reproducibility was reported frequently (68%), whereas information about indeterminate results was rarely provided. The mean number of methodologic criteria satisfied showed a statistically significant increase over the 3 years in Clinical Chemistry but not in Clinical Chemistry and Laboratory Medicine. CONCLUSIONS: The methodologic quality of the articles on diagnostic test research published in Clinical Chemistry and Clinical Chemistry and Laboratory Medicine is comparable to the quality observed in the best general medical journals. The methodologic aspects that most need improvement are those linked to the clinical information of the populations studied. Editorial actions aimed to increase the quality of reporting of diagnostic studies could have a relevant positive effect, as shown by the improvement observed in Clinical Chemistry.  (+info)

Modeling interventions to improve access to public health information. (24/351)

In a Robert Wood Johnson funded project, we established a model-based means for automatically analyzing and representing grey literature that reports on public health (PH) interventions. We summarize the development of an intervention model for public health documents and provide a project update on the implementation of natural language technology to improve access to difficult to find public health information.  (+info)