Acute upper genital-tract disease in female monkeys provoked experimentally by Mycoplasma genitalium.
(2/5)
The oviducts of two grivet monkeys and three marmosets, all sexually mature animals, were inoculated with Mycoplasma genitalium at laparotomy. The mycoplasma was not recovered from the grivet monkeys, nor from the oviducts of the marmosets although it was isolated intermittently from the vagina of two of the latter animals up to 4-6 weeks after inoculation. In contrast, all of the animals developed antibody to M. genitalium measured by a micro-immunofluorescence technique. It developed rapidly in the grivet monkeys but slowly in the marmosets, being detected first about 1 month after inoculation with a maximal response by 2 months. Furthermore, despite an absence of vaginal discharge or cytological response, all the animals developed a moderate to severe endosalpingitis characterized by the infiltration of acute inflammatory cells into the tubal epithelium, together with a lumenal exudate and adhesions between the mucosal folds. The changes are similar to those produced by Chlamydia trachomatis in simian models and naturally in women. (+info)
Some operative and postoperative hazards of legal termination of pregnancy.
(3/5)
Analysis of 1,317 patients admitted for N.H.S. abortion showed an overall morbidity of 16.8% excluding urinary tract infection. Genital infection, chest infection, reevacuation or perforation of the uterus, and haemorrhage were the more common complications. There was one maternal death. (+info)
Experimental infection of the upper genital tract of female grivet monkeys with Mycoplasma fermentans.
(4/5)
Mycoplasma fermentans inoculated directly into the uterine tubes of female grivet monkeys produced a self-limiting acute salpingitis and parametritis. The inflammation was accompanied by a significant rise in titre of specific indirect haemagglutinating antibodies. Inoculation of M. fermentans into the uterine cavity through the cervical canal without dilatation of the cervix produced practically no signs of inflammation and no antibody response. However, when the intrauterine inoculation of mycoplasmas was followed by currettage of the endometrium, in animals whose uterine tubes had been closed by ligatures, pronounced upper genital-tract inflammation developed, together with a significant antibody response. (+info)
Experimental infection of the genital tract of female grivet monkeys by Mycoplasma hominis.
(5/5)
Mycoplasma hominis, a common inhabitant of the mucosae of the genitourinary tract of human and nonhuman primates, was inoculated directly into the uterine tubes of five laparotomized grivet monkeys. A self-limiting acute salpingitis and parametritis developed within a few days in all animals. Although there were no clinical signs of overt disease, the gross pathology was characterized by pronounced oedematous swelling and hyperaemia of the tubes and parametria. Microscopically, cellular infiltrations of lymphocytes and some polymorphonuclear leukocytes were found in the acute phase in the subserosa and muscularis of the tubes and in the parametria. Granulation tissue and fat necrosis appeared at a later stage in the parametria. The infection was associated with a marked antibody response and a moderate rise of the erythrocyte sedimentation rate and leukocyte counts. The capability of M. hominis to produce salpingitis and parametritis in a nonhuman primate would seem to add rather significantly to the available evidence suggesting an etiological role of this organism in inflammatory diseases of the internal female genitals of humans. (+info)