Cerebrospinal fluid rhinorrhoea from massive osteolysis of the skull.
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Involvement of the skull by a rare disorder-massive osteolysis-led to CSF rhinorrhoea and meningitis. This is believed to be the first time that such a case has been reported. (+info)
Bone and soft tissue changes in paraplegic patients.
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The loss of bone mineral in 66 paraplegic patients has been measured in the lower femoral shaft by scanning the leg with a beam of mono-energetic radiation from 241Am. The profile of the transmitted radiation was used to determine a parameter which was related to bone mass. The bone mass of paraplegic patients was significantly lower than normal. Persistent paralysis does not lead to a continued fall in bone mass, but once it has fallen, bone mass remains constant. Soft tissues also showed a muscle/fat ratio was lower than normal. (+info)
Intraosseous hemangiomatosis: technetium-99m(V)dimercaptosuccinic acid and technetium-99m-hydroxymethylene diphosphonate imaging.
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We report a case of histologically proven intraosseous hemangiomatosis in which marked accumulation of pentavalent technetium-99m-dimercaptosuccinic acid (99mTc(V)DMSA) and technetium-99m-hydroxymethylene diphosphonate (99mTc-HMDP) was observed in the osteolytic hemangiomatous lesions. (+info)
Gorham's syndrome: a usually fatal cause of pleural effusion treated successfully with radiotherapy.
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A 21 year old man presented with a right sided pleural effusion. Destruction of the 11th and 12th right ribs and adjacent vertebral bodies was noted on computed tomographic scanning. An open rib biopsy revealed the histopathological changes of Gorham's syndrome. In view of the progressive vertebral destruction and inevitable spinal cord compromise, he was treated with high dose radiotherapy. The process was arrested and he remains well with no signs of recurrence after four years. Pleural effusion and vertebral destruction complicating Gorham's syndrome carry a poor prognosis but, in this case, high dose radiotherapy has been effective in controlling both the effusion and the progressive bony destruction. (+info)
Chylothorax may rarely occur in osteolysis. A fatal case of bilateral chylothorax complicating massive osteolysis is described and the pathogenesis and management are discussed. (+info)
Pathology of disappearing bone disease: a case report with immunohistochemical study.
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A case of disappearing bone disease of the proximal femur is reported with histopathological and immunohistochemical studies. There was a densely packed cellular tissue, positive to endothelial antibodies, in areas of massive bone destruction. A more differentiated vascular tissue was present where trabecular cancellous or cortical bone was preserved with only focal zones of accelerated bone remodelling. The self-limited course correlates well with two phases of evolution of the histopathological lesions with neoplastic-like proliferation of endothelial cells corresponding to the rapid and massive bone destruction, and a later differentiation of the cells in mature vascular structures, but still with accelerated bone resorption which is partly compensated by appositional activity. (+info)
Review of septic arthritis throughout the antibiotic era.
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134 patients with septic arthritis who have been treated at the Nuffield Orthopaedic Centre during a 30-year period have been reviewed. There has been little change in the overall incidence during the last 20 years, but recently the disease has become more common among the elderly and patients tend to be less ill on presentation. The problems and necessity of rapidly establishing a diagnosis are stressed. Overall, 70% attained a good result though infection in infants' hips and all joints in the elderly carried a poor prognosis. Once a good result was achieved the joint did not deteriorate with the passage of time. (+info)