An inverse oblique effect in human vision.
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In the classic oblique effect contrast detection thresholds, orientation discrimination thresholds, and other psychophysical measures are found to be smallest for vertical or horizontal stimuli and significantly higher for stimuli near the +/-45 degrees obliques. Here we report a novel inverse oblique effect in which thresholds for detecting translational structure in random dot patterns [Glass, L. (1969). Moire effect from random dots. Nature, 223, 578-580] are lowest for obliquely oriented structure and higher for either horizontal or vertical structure. Area summation experiments provide evidence that this results from larger pooling areas for oblique orientations in these patterns. The results can be explained quantitatively by a model for complex cells in which the final filtering stage in a filter-rectify-filter sequence is of significantly larger area for oblique orientations. (+info)
Spatial-frequency and contrast properties of crowding.
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Crowding, the difficulty in recognizing a letter flanked by other letters, has been explained as a lateral masking effect. The purpose of this study was to examine the spatial-frequency and contrast dependencies of crowding, and to compare them with the properties of pattern masking. In experiment 1, we measured contrast thresholds for identifying the middle letters in strings of three randomly chosen lower-case letters (trigrams), for a range of letter spacings. Letters were digitally filtered using a set of bandpass filters, with peak object spatial frequencies ranging from 0.63 to 10 c/letter. Bandwidth of the filters was 1 octave. Frequencies of the target and flanking letters were the same, or differed by up to 2 octaves. Contrast of the flanking letters was fixed at the maximum value. Testing was conducted at the fovea and 5 degrees eccentricity. We found that crowding exhibits spatial-tuning functions like masking, but with generally broader bandwidths than those for masking. The spatial extent of crowding was found to be about 0.5 deg at the fovea and 2 deg at 5 degrees eccentricity, independent of target letter frequency. In experiment 2, we measured the contrast thresholds for identifying the middle target letters in trigrams for a range of flanking letter contrasts at 5 degrees eccentricity. At low flanker contrast, crowding does not show a facilitatory region, unlike pattern masking. At high flanker contrast, threshold rises with contrast with an exponent of 0.13-0.3, lower than corresponding exponents for pattern masking. In experiment 3, we varied the contrast ratio between the flanking letters and the target letters, and found that the magnitude of crowding increases monotonically with contrast ratio. This finding contradicts a prediction based on a grouping explanation for crowding. Our results are consistent with the postulation that crowding and masking may share the same first stage linear filtering process, and perhaps a similar second-stage process, with the additional property that the second-stage process in crowding pools information over a spatial extent that varies with eccentricity. (+info)
Information theoretical evaluation of parametric models of gain control in blowfly photoreceptor cells.
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Models are developed and evaluated that are able to describe the response of blowfly photoreceptor cells to natural time series of intensities. Evaluation of the models is performed using an information theoretical technique that evaluates the performance of the models in terms of a coherence function and a derived coherence rate (in bit/s). Performance is gauged against a maximum expected coherence rate determined from the repeatability of the response to the same stimulus. The best model performs close to this maximum performance, and consists of a cascade of two divisive feedback loops followed by a static nonlinearity. The first feedback loop is fast, effectively compressing fast and large transients in the stimulus. The second feedback loop also contains slow components, and is responsible for slow adaptation in the photoreceptor in response to large steps in intensity. Any remaining peaks that would drive the photoreceptor out of its dynamic range are handled by the final compressive nonlinearity. (+info)
The shape of the aging human lens: curvature, equivalent refractive index and the lens paradox.
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Scheimpflug slit images of the crystalline lens are distorted due to the refracting properties of the cornea and because they are obliquely viewed. We measured the aspheric curvature of the lens of 102 subjects ranging in age between 16 and 65 years and applied correction for these distortions. The procedure was validated by measuring an artificial eye and pseudophakic patients with intraocular lenses of known dimensions. Compared to previous studies using Scheimpflug photography, the decrease of the radius of the anterior lens surface with age was smaller, and the absolute value for the radius of the anterior and posterior lens surface was significantly smaller. A slight decrease of the posterior lens radius with age could be demonstrated. Generally, front and back surfaces were hyperbolic. Axial length was measured of 42 subjects enabling calculation of the equivalent refractive index of the lens, which showed a small, but highly significant decrease with age. These new findings explain the lens paradox and may serve as a basis for modelling the refractive properties of the lens. (+info)
Response to influenza immunisation during treatment for cancer.
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AIMS: To assess the annual risk of influenza infection in children with cancer and the immunogenicity of a trivalent split virus influenza vaccine in these children. METHODS: Eighty four children with cancer were tested for susceptibility to the circulating strains of influenza virus in autumn 1995 and 1996. Non-immunised children were reassessed the following spring for serological evidence of natural infection. Forty two patients received two doses of influenza vaccine. These children were receiving continuing chemotherapy for acute lymphoblastic leukaemia or were within six months of completing chemotherapy. RESULTS: Among the 84 children tested for influenza virus susceptibility only 8% of patients were fully protected (antibody titres >/= 40) against all three of the prevalent influenza virus strains; 33% were susceptible to all three viruses. Evidence of acquired natural infection was seen in 30% of unimmunised patients. Among immunised susceptible patients, 66% made some protective response to the vaccine and 55% showed protective antibody titres to all three viral strains following vaccination. Older age was associated with increased response to the H1N1 and H3N2 vaccine components, but total white cell count or neutrophil count at immunisation, type of cancer, or length of time on treatment for acute lymphoblastic leukaemia did not affect response. CONCLUSIONS: Most children with cancer studied were at risk of influenza infection. A significant response to immunisation was seen, supporting annual influenza vaccination for children being treated for cancer. (+info)
Corneal autofluorescence in choroidal melanoma or in choroidal naevus.
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AIMS: To investigate whether corneal autofluorescence is different in patients with choroidal melanoma or choroidal naevus. METHODS: Corneal autofluorescence was determined by fluorophotometry in both eyes of 32 patients with a unilateral choroidal melanoma, 32 patients with a unilateral choroidal naevus, and 32 age matched healthy controls. The corneal autofluorescence ratio between affected and contralateral eyes of patients or between randomly selected eyes of healthy controls was calculated. RESULTS: Mean corneal autofluorescence ratio of patients with a choroidal melanoma was significantly higher than that of healthy controls (mean ratio: 1.09 (SD 0.15) and 1.00 (0.09), respectively, ANOVA p=0.014), and than that of patients with choroidal naevus (mean ratio 0.96 (0.09), p<0.001). Mean ratios of patients with choroidal naevus and healthy controls were not significantly different (p=0.27). CONCLUSIONS: Corneal autofluorescence ratio of patients with a unilateral choroidal melanoma is increased. This is probably due to an increased flow of glucose through the impaired blood-aqueous barrier in the affected eye, resulting in additional glycation of corneal proteins and hence in increased autofluorescence. The corneal autofluorescence is not increased in patients with a choroidal naevus, because the blood-aqueous barrier is not impaired in the affected eye in these patients. Measurement of corneal autofluorescence is simple, fast, and non-invasive, and might be helpful to distinguish between patients with choroidal melanoma and those with choroidal naevus. (+info)
Activation of the endothelin system in insulin resistance.
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Endothelin-1, released from the vascular endothelium after cleavage from big endothelin-1, is a potent paracrine vasoconstrictor peptide. Small studies suggest that circulating levels of endothelin-1 are elevated in subjects with cardiovascular risk factors. Big endothelin-1 levels may better reflect endothelin-1 generation. We examined relationships between plasma endothelin-1, plasma big endothelin-1, and predisposition to hypertension or other cardiovascular risk factors associated with insulin resistance in a large group of healthy young men. We recruited 96 healthy men aged 24-33 years from a cohort of 864 young men and women in whom predisposition to hypertension had been defined on the basis of their own blood pressure and the blood pressures of their parents. They attended after an overnight fast for measurement of blood pressure, anthropometry, and plasma lipids, insulin, glucose, endothelin-1 and big endothelin-1. Plasma endothelin-1 and big endothelin-1 levels did not correlate with blood pressure (r=0.09, -0.002 respectively) and were not influenced by parental blood pressure. Higher plasma endothelin-1 levels were associated with higher body mass index (r=0.29, p<0.005), and higher plasma insulin (r=0.21, p<0.05). Higher plasma big endothelin-1 levels were associated with insulin resistance, as assessed by the Homeostasis Model of Assessment resistance index (r=0.30, p<0.005). Endothelin-1 levels are not related to blood pressure, but are higher in healthy young men with insulin resistance and obesity. (+info)
Compliance with inhaled glucocorticoids and concomitant use of long-acting beta2-agonists.
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We investigated whether treatment with a long-acting beta2-agonist (LAbeta2) is associated with a decrease in patient compliance with regard to inhalation corticosteroids (ICS). Date on prescriptions collected by 15,760 patients suffering from airways disease were provided by 69 Dutch pharmacies. All prescriptions of ICS and LAbeta2 were analysed and divided in four groups by LAbeta2 use during 1997 and 1998. Date from 15,760 patients were available. In the 10,929 patients not treated with LAbeta2, compliance decreased slightly but not significantly. In 3281 patients receiving LAbeta2 compliance also decreased slightly but not significantly. In 404 patients, who used a LAbeta2 in 1997 and discontinued treatment in 1998, the compliance fell significantly (P<0.05). In 1147 patients who started to use a LAbeta2 in 1998, compliance with ICS significantly improved (P<0.05). These results suggest that the regular use of LAbeta2 improves compliance with ICS. Therefore, the concern that compliance with inhaled corticosteroid therapy will decrease under concomitant use of LAbeta2 appear to be unfounded. (+info)