Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control. (49/104)

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General practitioners' experiences with provision of healthcare to patients with self-reported multiple chemical sensitivity. (50/104)

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Functional impairment in chronic fatigue syndrome, fibromyalgia, and multiple chemical sensitivity. (51/104)

OBJECTIVE: To characterize patients diagnosed with multiple chemical sensitivity (MCS), chronic fatigue syndrome (CFS), or fibromyalgia (FM), to compare their level of function with Canadian population average values, and to assess factors associated with function. DESIGN: Chart review and abstraction of clinical information. SETTING: The Environmental Health Clinic (EHC) at Women's College Hospital in Toronto, Ont, which is a provincial referral centre for patients with illnesses with suspected environmental links, especially MCS, CFS, and FM. PARTICIPANTS: A total of 128 consecutive patients diagnosed with 1 or more of MCS, CFS, or FM, seen between January 2005 and March 2006 at the EHC. MAIN OUTCOME MEASURES: Demographic and socioeconomic characteristics, comorbid diagnoses, duration of illness, health services usage, life stresses, helpful therapeutic strategies, and functional impairment measured by the Short Form-36, compared with Canadian population average values. Factors significantly associated with function in bivariate analyses were included in multiple linear and logistic regression models. RESULTS: The patient population was predominantly female (86.7%), with a mean age of 44.6 years. Seventy-eight patients had discrete diagnoses of 1 of MCS, CFS, or FM, while the remainder had 2 or 3 overlapping diagnoses. Most (68.8%) had stopped work, and on average this had occurred 3 years after symptom onset. On every Short Form-36 subscale, patients had markedly lower functional scores than population average values, more so when they had 2 or 3 of these diagnoses. Having FM, younger age at onset, and lower socioeconomic status were most consistently associated with poor function. CONCLUSION: Patients seen at the EHC demonstrated marked functional impairment, consistent with their reported difficulties working and caring for their homes and families during what should be their peak productive years. Early comprehensive assessment, medical management, and social and financial support might avoid the deterioration of function associated with prolonged illness. Education and information resources are required for health care professionals and the public, along with further etiologic and prognostic research.  (+info)

Odors eliciting fear: a conditioning approach to Idiopathic Environmental Intolerances. (52/104)

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The association between idiopathic environmental intolerance and psychological distress, and the influence of social support and recent major life events. (53/104)

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Affected by smells? Environmental chemical responsivity predicts odor perception. (54/104)

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The search for reliable biomarkers of disease in multiple chemical sensitivity and other environmental intolerances. (55/104)

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Factors in genetic susceptibility in a chemical sensitive population using QEESI. (56/104)

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