Multiplexing ligand-receptor binding measurements by chemically patterning microfluidic channels. (1/75)

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The recombinational anatomy of a mouse chromosome. (2/75)

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Analysis of ketoprofen and mefenamic acid by high-performance liquid chromatography with molecularly imprinted polymer as the stationary phase. (3/75)

A simple and sensitive high-performance liquid chromatographic method for simultaneous determination of ketoprofen and mefenamic acid in tablets has been developed. HPLC with UV detection (220 nm) was performed on an analytical column packed with molecularly imprinted polymer (MIP) as the stationary phase. The MIPs are prepared by bulk polymerisation followed by crushing and sieving to the desired particle size. In this paper, we selected ketoprofen, methacrylic acid, and ethylene glycoldimethacrylate as template, functional monomer, and crosslinker in the presence of chloroform as the solvent. The retention times of mefenamic acid and ketoprofen were approximately 5 and 20 min, respectively. In order to compare the chromatographic data from the stationary phase, separation factors (alpha) were given. The values of alpha were 4.36 approximately 4.39 and showed that the MIPs were able to recognize structurally subtle differences from the template molecule. The limits of detection for ketoprofen and mefenamic acid were found to be 0.029 and 0.038 (g/L), while the limits of quantitation were 0.097 and 0.127 (g/L), respectively. Our results showed good accuracy, indicating that a ketoprofen-selective polymer was suitable for ketoprofen and mefenamic acid separations. Therefore, the MIPs are certainly applied to commercial tablet analysis.  (+info)

Computational insights on sulfonamide imprinted polymers. (4/75)

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Nanoimprinted thin films of reactive, azlactone-containing polymers: combining methods for the topographic patterning of cell substrates with opportunities for facile post-fabrication chemical functionalization. (5/75)

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Examination of imprinting process with molsidomine as a template. (6/75)

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An electrochemical sensor for phenylephrine based on molecular imprinting. (7/75)

Molecularly imprinted polymers (MIPs) were applied as molecular recognition elements to an electrochemical sensor for phenylephrine. A MIPs membrane was created on a glassy carbon electrode. SEM revealed a gradual change on the morphology of modified electrodes as the ratios of function monomer and cross-linking varied. When the ratio was 4:40, the surface morphology between the imprinted electrode (M-electrode) and the control electrode (N-electrode) became unambiguously different. This artificial receptor exhibited high selectivity for the template compared to closely related analogue. The response of the sensor varied in different concentration range might due to the heterogeneity of the MIPs membrane. This sensor was also used to determine phenylephrine in tablet samples.  (+info)

Hybrid separation and detection device for analysis of benzene, toluene, ethylbenzene, and xylenes in complex samples. (8/75)

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