Chronic ethanol attenuates centrally-mediated hypotension elicited via alpha(2)-adrenergic, but not I(1)-imidazoline, receptor activation in female rats.
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A newborn with positive antiglobulin test whose mother took methyldopa in pregnancy.
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Methyldopa is known to cause the production of autoantibodies against red blood cells (RBCs), leading to a positive direct antiglobulin test (DAT) and hemolytic anemia. In about 20% of patients taking methyldopa, IgG autoantibodies develop against RBCs. However, most of the patients do not have hemolysis. A small percentage of such DAT-positive patients, about 2% of those taking methyldopa, develop an autoimmune hemolytic anemia (AIHA). The fact that the DAT is positive in the newborn with unconjugated hyperbilirubinemia is considered as an isoimmune hemolytic disease caused by blood group incompatibility. In this article, a newborn with jaundice and positive DAT without hemolysis is reported. Her mother had the history of taking methyldopa in her pregnancy. Thus, when newborns are detected with positive DAT and jaundice, without blood group incompatibility, mothers should be questioned regarding drugs used in their pregnancy. (+info)
Increased local dopamine secretion has growth-promoting effects in cholangiocarcinoma.
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Effect of pH on the oxidation pathway of alpha-methyldopa catalysed by tyrosinase.
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This paper deals with the quantitative description of the effect of pH on the oxidation pathway of alpha-methyldopa. Tyrosinase catalyses the oxidation by molecular oxygen of alpha-methyldopa to o-alpha-methyldopaquinone, which evolves non-enzymically through a branched pathway with cyclization or hydroxylation reactions. The intermediates of the hydroxylation branch have been identified, and the corresponding rate constants have been determined. These compounds, which have been detected in melanosomes and in tumour cells, have great cytotoxic power and could have physiological significance in acidic media. (+info)
Preparation and evaluation of a new nano pharmaceutical excipients and drug delivery system based in polyvinylpyrrolidone and silicate.
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PURPOSE: This work describes the preparation of new nanocomposites based on lamellar silicates (AAM-alkyl ammonium montmorillonite) obtained by the intercalation of PVP K30 and glyceril monostearate. METHODS: By XRD, TGA and DSC analysis the AAM was characterized and its compactation characteristics, functionality and toxicity were also tested. The AAM/PVP K-30 and AAM/GME nanocomposite obtained were evaluated to identify the interlamellar spacing values by XRD diffratograms. Tablets were prepared using methyldopa and theophylline as model drugs and the dissolution tests were carried out in simulated gastric fluid and simulated enteric fluid. RESULTS: AAM showed a good compactability and compressibility characteristics for tablets preparation. The intercalation yields (approximately 25%) of the nanocomposites were efficient. The AAM/PVP K-30 nanocomposites were successfully tested as dissolution enhancers and sustained release matrixes. CONCLUSIONS: The results also suggested the promising use of AAM (viscogel B8) and the new nanocomposite prepared by clay/PVP K-30 intercalation as a new matrix for sustained release and the feasibility of using these new nanocomposites as dissolution enhancer. (+info)
Different culture media containing methyldopa for melanin production by Cryptococcus species.
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Therapeutic effect of a moderate intensity interval training program on the lipid profile in men with hypertension: a randomized controlled trial.
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