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Matrix Metalloproteinase 2Matrix Metalloproteinase 9Matrix Metalloproteinase InhibitorsMatrix Metalloproteinase 14Matrix Metalloproteinase 1Matrix Metalloproteinase 3Matrix MetalloproteinasesMetalloendopeptidasesMatrix Metalloproteinase 13Matrix Metalloproteinase 7Matrix Metalloproteinases, Membrane-AssociatedExtracellular MatrixTissue Inhibitor of Metalloproteinase-2Matrix Metalloproteinase 8Matrix Metalloproteinase 12Tissue Inhibitor of Metalloproteinase-1CollagenasesGelatinasesMatrix Metalloproteinase 10Matrix Metalloproteinase 11Tissue Inhibitor of MetalloproteinasesAntigens, CD147MetalloproteasesProtease InhibitorsMatrix Metalloproteinase 15Matrix Metalloproteinases, SecretedMatrix Metalloproteinase 16CollagenExtracellular Matrix ProteinsTissue Inhibitor of Metalloproteinase-3Matrix Metalloproteinase 20Enzyme PrecursorsCells, CulturedNeoplasm InvasivenessRNA, MessengerGene Expression Regulation, EnzymologicCell MovementADAM ProteinsMatrix Metalloproteinase 17GelatinFibroblastsReverse Transcriptase Polymerase Chain ReactionBlotting, WesternPhenylmercuric AcetateEnzyme ActivationCollagen Type IImmunohistochemistryCell Line, TumorChondrocytesDipeptidesUp-RegulationCartilage, ArticularHemopexinThiophenesMolecular Sequence DataSynovial MembraneNuclear MatrixProteoglycansOsteoarthritisHydroxamic AcidsDisease Models, AnimalAmino Acid SequenceFibronectinsSignal TransductionDoxycyclineProcollagen N-EndopeptidaseTumor Cells, CulturedAggrecansEnzyme InhibitorsCartilageMice, Inbred C57BLLamininBone MatrixGene ExpressionMice, KnockoutCulture Media, ConditionedRecombinant ProteinsEnzyme InductionElastinPhenylalanineCell LineCell ProliferationTransfectionFurinTime FactorsCollagen Type IIIFibrosisVentricular RemodelingNeovascularization, PathologicMicrobial CollagenaseGene Expression RegulationUrokinase-Type Plasminogen ActivatorBase SequenceInterleukin-1Enzyme-Linked Immunosorbent AssayCollagen Type IIDown-RegulationWound HealingTumor Necrosis Factor-alphaDose-Response Relationship, Drug

MT2-MMP-dependent release of collagen IV NC1 domains regulates submandibular gland branching morphogenesis. (17/39)

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Induction of a MT1-MMP and MT2-MMP-dependent basement membrane transmigration program in cancer cells by Snail1. (18/39)

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Membrane-type MMPs are indispensable for placental labyrinth formation and development. (19/39)

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Proteolytic cleavage of versican and involvement of ADAMTS-1 in VEGF-A/VPF-induced pathological angiogenesis. (20/39)

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Silencing of the MMP-3 gene by siRNA transfection in gastric cancer AGS cells. (21/39)

BACKGROUND: The gastric epithelium is continuously exposed to toxic reactive oxygen species and matrix metalloproteinases (MMPs) are the enzymes known for their roles in the invasion of tumor cells. Here, we report the suppression of matrix metalloproteinase 3 (MMP-3) in gastric cancer cell line AGS by small interfering RNA (siRNA) transfection and its potential role in gastric cancers. METHODS: Oxidative stress in the cell lines was assessed following H2O2 exposure using an oxidative stress marker, 2,7-dichlorofluorescein diacetate (DCFDA). Transfection of cells with small interfering RNA specific to MMP-3, Transwell invasion assay, quantitative reverse transcriptase polymerase chain reaction analysis, and over-expression of MMP-3 were used to determine the potential role of MMP-3 gene in gastric cancers. RESULTS: The silencing of the MMP-3 gene resulted in a decrease of invading AGS while the over-expression of it caused an increase in the invading cells compared to the untreated control cells. Moreover, it also caused a 4.1 fold increase in matrix metalloproteinase 10 (MMP-10) and a 7.4 fold decrease in matrix metalloproteinase 15 (MMP-15) mRNA expression levels. CONCLUSIONS: Our results show that the silencing of the MMP-3 gene decreases the number of invading AGS cells and additionally, affects the expressions of MMP-10 and MMP-15, suggesting that targeting the MMP-3 gene in gastric cancers might be a therapeutic approach due to its effects on the invasion of AGS cells and the expression of the MMP-15 gene.  (+info)

Dynamics of salivary gland morphogenesis. (22/39)

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Mmp15 is a direct target of Snai1 during endothelial to mesenchymal transformation and endocardial cushion development. (23/39)

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Sorafenib treatment of FLT3-ITD(+) acute myeloid leukemia: favorable initial outcome and mechanisms of subsequent nonresponsiveness associated with the emergence of a D835 mutation. (24/39)

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