Clinical decision support systems: perspectives in dentistry.
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Clinical decision-support systems (CDSSs) are computer programs that are designed to provide expert support for health professionals making clinical decisions. The goal of these systems is to help health professionals analyze patient data and make decisions regarding diagnosis, prevention, and treatment of health problems. This article discusses the characteristics of such systems, addresses the challenges in developing them, identifies potential barriers for their use in clinical practice, and provides perspectives for the future. (+info)
Medical ethics, logic traps, and game theory: an illustrative tale of brain death.
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Decision making and choices are frequent themes in medical ethics. Game theory is based upon modelled decision making. Game theory, and associated logic traps, may have relevance to the clinical practice of medicine and medical ethics. The "prisoner's dilemma" is one logic trap from game theory in which "rational" decision making on the part of participating individuals can lead to "suboptimal" situations. An example of such a situation involving brain death is presented and discussed from the perspective of the prisoner's dilemma. (+info)
Response to: A rational cure for pre-reproductive stress syndrome.
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This response to "A rational cure for pre-reproductive stress syndrome" first suggests it is existence that is essential and prerequisite to everything good or bad, therefore it deserves to be protected and respected. Secondly, it argues that every life is worth living, even if it is worse than some other lives, if the only alternative is non-existence. Finally, it takes a critical view of and challenges Hayry's suggestion that in a good clinical situation, the idea of the irrationality of having children could be a legitimate part of the guidance given, since it is not the counsellor's or doctor's duty to advise a couple who wish to have children that it is irrational or even immoral to bring a child into life. (+info)
Audism: exploring the metaphysics of oppression.
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This article traces the development of the concept of "audism" from its inception in the mid-1970s by exploring three distinct dimensions of oppression: individual, institutional, and metaphysical. Although the first two aspects of audism have been identified, there is a deeply rooted belief system regarding language and human identity that is yet to be explored within the context of audism. This article attempts to expose how our particular historical and philosophical constructions of language and being have created what French philosopher Jacques Derrida calls phonocentrism. Although Derrida does not discuss audism, his deconstruction of the Western notion of language provides a lens through which we can better see the orientation that has provided fertile ground out of which individual and institutional audism has flourished. (+info)
Activities and sensitivities in boolean network models.
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We study how the notions of importance of variables in Boolean functions as well as the sensitivities of the functions to changes in these variables impact the dynamical behavior of Boolean networks. The activity of a variable captures its influence on the output of the function and is a measure of that variable's importance. The average sensitivity of a Boolean function captures the smoothness of the function and is related to its internal homogeneity. In a random Boolean network, we show that the expected average sensitivity determines the well-known critical transition curve. We also discuss canalizing functions and the fact that the canalizing variables enjoy higher importance, as measured by their activities, than the noncanalizing variables. Finally, we demonstrate the important role of the average sensitivity in determining the dynamical behavior of a Boolean network. (+info)
Boolean logic functions of a synthetic peptide network.
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Living cells can process rapidly and simultaneously multiple extracellular input signals through the complex networks of evolutionary selected biomolecular interactions and chemical transformations. Recent approaches to molecular computation have increasingly sought to mimic or exploit various aspects of biology. A number of studies have adapted nucleic acids and proteins to the design of molecular logic gates and computational systems, while other works have affected computation in living cells via biochemical pathway engineering. Here we report that de novo designed synthetic peptide networks can also mimic some of the basic logic functions of the more complex biological networks. We show that segments of a small network whose graph structure is composed of five nodes and 15 directed edges can express OR, NOR, and NOTIF logic. (+info)
Are patents for methods of medical treatment contrary to the ordre public and morality or "generally inconvenient"?
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"No one has advanced a just and logical reason why reward for service to the public should be extended to the inventor of a mechanical toy and denied to the genius whose patience, foresight, and effort have given a valuable new [discovery] to mankind" (Katopis CJ. Patents v patents: policy implications of recent patent legislation. St John's Law Review 1997;71:329). The law around the world permits the granting of patents for drugs, medical devices, and cosmetic treatment of the human body. At the same time, patentability for a method of treatment of the same body is denied in some countries on various public policy grounds. Is there any logical justification for this distinction? Are methods of medical treatment not as vital to the health or even to the life of a patient as drugs or medical devices? Why is a cosmetic result patentable and a curative result not? (+info)
The impact of two multiple-choice question formats on the problem-solving strategies used by novices and experts.
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BACKGROUND: Pencil-and-paper examination formats, and specifically the standard, five-option multiple-choice question, have often been questioned as a means for assessing higher-order clinical reasoning or problem solving. This study firstly investigated whether two paper formats with differing number of alternatives (standard five-option and extended-matching questions) can test problem-solving abilities. Secondly, the impact of the alternatives number on psychometrics and problem-solving strategies was examined. METHODS: Think-aloud protocols were collected to determine the problem-solving strategy used by experts and non-experts in answering Gastroenterology questions, across the two pencil-and-paper formats. RESULTS: The two formats demonstrated equal ability in testing problem-solving abilities, while the number of alternatives did not significantly impact psychometrics or problem-solving strategies utilized. CONCLUSIONS: These results support the notion that well-constructed multiple-choice questions can in fact test higher order clinical reasoning. Furthermore, it can be concluded that in testing clinical reasoning, the question stem, or content, remains more important than the number of alternatives. (+info)