How much pharyngeal exposure is "normal"? Normative data for laryngopharyngeal reflux events using hypopharyngeal multichannel intraluminal impedance (HMII).
(26/48)
Delayed gastric emptying in an indonesian population with reflux esophagitis.
(28/48)
AIM: to observe the delayed gastric emptying in patients with reflux esophagitis as well as to recognize the proportion of GERD patients who have delayed gastric emptying in Indonesian population by using standard scintigraphic method. METHODS: patients with heartburn and/or regurgitation in the last six-month period were included in the study. After endoscopic examination of upper gastrointestinal tract, scintigraphic examination was performed in appropriate to Consensus Recommendation for Gastric Emptying Scintigraphy with standard 99Tc-labeled egg-white meal of 255 kcal. Delayed gastric emptying was defined when there was gastric retention >90% at 1 hour, >60% at 2 hours and >10% at 4 hours. RESULTS: twenty-three patients with reflux esophagitis were compared to 23 subjects with Non-erosive reflux disease (NERD). Subjects with reflux esophagitis demonstrated slower gastric emptying compared to subjects with NERD at 1 hour (p<0.05), 2 hours (p<0.05) and 4 hours (p<0.05). Gastric retention >10% at 4 hours was found in 6% patients with GERD (2 patients with reflux esophagitis and 1 patient with NERD). CONCLUSION: gastric emptying in patients with reflux esophagitis is significantly slower than in patients with NERD. (+info)
Combination of PPI with a prokinetic drug in gastroesophageal reflux disease.
(29/48)
AIM: to evaluate the efficacy of combination of PPI with prokinetic drug compared to PPI mono therapy in GERD patients with high frequency scale for the symptoms of GERD (FSSG) score. METHODS: sixty dyspeptic patients having heartburn and/or regurgitation were recruited during the period of July 2010-April 2011 in this double blind clinical trial. By randomization, they were divided into two groups; group A was given omeprazole 2 x 20 mg and domperidone 3 x 10 mg for 2 weeks, while another group was only given omeprazole 2 x 20 mg. The FSSG score was performed before treatment and after 2 weeks of treatment. RESULTS: there were 20 (33%) males and 40 (67%) females. The mean total score of FSSG was 25.3 +/- 8.2 at pretest, and 19.3 +/- 9.7 at posttest, with improvement of 6.1 +/- 4.9. The FSSG score in group A after treatment (19.3 +/- 11.3) was significantly lower than before treatment (26.7 +/- 8.9, p<0.001) as well as in group B (from 23.9 +/- 7.3 to 19,3 +/- 7.9, p<0.001). The mean improvement score in group A was 7.5 +/- 5.9, while in the group B was of 4.6 +/- 3.3, and this difference was statistically significant (p=0.02) CONCLUSION: combination of omeprazole with domperidone in GERD patients with high FSSG score is more superior compared to omeprazole monotherapy. (+info)
No significant association between halitosis and upper gastrointestinal endoscopic findings: a prospective study.
(30/48)
BACKGROUND: Previous studies have focused on the relationship between halitosis, gastroesophageal reflux disease and Helicobacter pylori. In this study we aimed to investigate the interaction between halitosis and upper gastrointestinal endoscopic findings. METHODS: Patients who previously had dyspepsia and had undergone endoscopic examination were included in the study. Symptoms of dyspepsia were investigated by means of a questionnaire that investigated halitosis. Patients who suffered from objective halitosis (confirmed by questions both to the patient and their relatives) were further investigated. Patients with known local or systemic causes of halitosis or structural disorders at endoscopy were excluded. RESULTS: The study included 358 patients (121 men and 237 women) with dyspeptic symptoms. The patients with and without halitosis had mean ages of (39.4 +/- 13.5) and (43.1 +/- 14.9) years, respectively. Patients without halitosis were significantly older than those in the halitosis group (P < 0.05). Patients in the halitosis group had significantly higher frequencies of regurgitation, bloating and nausea (P < 0.05) when compared to patients without halitosis. Endoscopic findings, including esophagitis, open cardia, hiatal hernia, gastritis and duodenitis, were comparable in the two groups. CONCLUSIONS: The frequency of halitosis was high in patients with dyspepsia who underwent upper gastrointestinal endoscopy. Halitosis had a close relationship with several upper gastrointestinal symptoms, including regurgitation, nausea and bloating. There was no significant association between upper gastrointestinal endoscopic findings and halitosis. (+info)
pH salivary analysis of subjects suffering from Sjogren's syndrome and laryngopharyngeal reflux.
(31/48)