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(1/1311) Generation of pig induced pluripotent stem cells with a drug-inducible system.

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(2/1311) The genetics of induced pluripotency.

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(3/1311) Induction of stem cell gene expression in adult human fibroblasts without transgenes.

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(4/1311) Pluripotency can be rapidly and efficiently induced in human amniotic fluid-derived cells.

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(5/1311) Signaling pathways controlling pluripotency and early cell fate decisions of human induced pluripotent stem cells.

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(6/1311) Adenoviral gene delivery can reprogram human fibroblasts to induced pluripotent stem cells.

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(7/1311) Clone- and gene-specific aberrations of parental imprinting in human induced pluripotent stem cells.

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(8/1311) Induced pluripotent stem cells from swine (Sus scrofa): why they may prove to be important.

Three recent papers, published almost simultaneously by different groups, have described the generation of induced pluripotent stem (iPS) cells from the pig, a species whose size, anatomy and physiology render them attractive as clinical models for the human. The approach used in each case was to infect somatic cells with integrating retroviral vectors designed to express four reprogramming genes (POU5F1, SOX2, cMYC and KLF4). The cell lines generated met the standard criteria for pluripotency, including the ability to differentiate along multiple tissue lineages. In most respects, the porcine iPS cells more resembled human embryonic stem cells and human iPS cells than their murine equivalents. Provided such porcine iPS cells can be "personalized" to specific pigs and then coaxed to differentiate along specific lineages, it should be possible to use such animals to test transplantation therapies with iPS cells for safety and efficacy before the procedures are applied to human patients.  (+info)