Sea urchin granuloma secondary to Strongylocentrotus purpuratus and Strongylocentrotus franciscanus.
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Sea urchin injuries have been associated with a variety of cutaneous lesions, ranging from acute, transient reactions, to more chronic inflammatory conditions that result in the formation of granulomas. Although diverse species of sea urchins have been reported to produce chronic cutaneous granulomas, the two most prevalent organisms found on the US West Coast, purple and red sea urchins (Strongylocentrotus purpuratus and Strongylocentrotus franciscanus), have not yet been reported to induce persistent granulomatosis in humans. We describe one case of a 35-year-old marine biologist with chronic cutaneous lesions produced after repeated exposures. The lesions were similar to the ones produced by other urchin species, consisting of small, firm, erythematous nodules on his palms, dorsum of the hands, elbows, and knees. Increased awareness of this condition, including its association with the two prevalent organisms on the West Coast, should lead to a more rapid diagnosis for those affected. This article reviews the types of injuries, clinical cutaneoous lesions, histopathological features, and pathogenesis of the chronic inflammatory process induced by sea urchins. (+info)
Caseating granulomata caused by hemostatic agent posing as metastatic leiomyosarcoma.
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BACKGROUND: As the number of minimally invasive and laparoscopic procedures increases, hemostatic agents are becoming more popular as a means of achieving rapid hemostasis. CASE REPORT: The patient is a 61-year-old woman who underwent a laparoscopic supracervical hysterectomy. FloSeal Hemostatic Matrix (Baxter Healthcare, Deerfield Illinois) was used at the conclusion of the procedure. RESULTS: Pathology unexpectedly revealed high-grade leiomyosarcoma of the uterus. The patient then presented to our facility for consultation and was scheduled for robotic trachelectomy and lymphadenectomy. Laparoscopy revealed nodular lesions throughout the abdomen and pelvis. Biopsies were performed and the case aborted. Final pathology however showed caseating foreign body giant cell granulomata in all specimens. No malignancy was found. The patient then underwent exploratory laparotomy, trachelectomy, and a staging procedure. All pathology specimens and pelvic washings were negative for malignancy. CONCLUSIONS: Use of gelatin-thrombin hemostatic agents may elicit a foreign body reaction leading to large giant cell granulomata. In this case, the presence of these granulomata mimicked metastatic disease. (+info)
Exposure to nanoparticles is related to pleural effusion, pulmonary fibrosis and granuloma.
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