Perivascular epithelioid cell tumour of the liver.
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Perivascular epithelioid cell tumour is not uncommon in the liver but seldom malignant. (+info)
Epithelioid hemangioendothelioma of the oral cavity: a case report.
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Epithelioid hemangioendothelioma is a rare vascular neoplasm which exhibits the potential for malignancy and recurrence as well as the ability to metastasize. Although numerous sites of involvement are possible, these tumors most commonly arise in soft tissues, lung, liver, bone, and lymph nodes. In this report, we describe a case of oral epithelioid hemangioendothelioma in a child. This tumor appeared as exophytic ulcerated painless masses in the maxillary and mandibular gingiva. Histologically, the tumor was composed of a proliferation of tumor cells arranged in nests, cords, and short strands. Epithelioid cells exhibited abundant eosinophilic cytoplasm with nuclear and cellular pleomorphism and intra-cytoplasmic vacuoles. (+info)
Epithelioid trophoblastic tumor: comparative genomic hybridization and diagnostic DNA genotyping.
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Diagnostic value of epithelioid cell granulomas in bronchoscopic biopsies.
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BACKGROUND: The granulomatous inflammatory response is a manifestation of many lung diseases. OBJECTIVE: To evaluate the diagnostic value of epithelioid cell granulomas in bronchoscopic biopsies in daily clinical practice. METHODS: The data of 105 patients with epithelioid cell granulomas in biopsy tissue who had undergone the bronchoscopic lung biopsy or bronchial biopsy at the Centre of Pulmonology and Allergology of Vilnius University Hospital Santariski klinikos (Vilnius, Lithuania) were examined. All cases were divided into non-necrotizing epithelioid cell granulomas and epithelioid cell granulomas with necrosis. RESULTS: Of all the cases 66% had non-necrotizing epithelioid cell granulomas and 34% had epithelioid cell granulomas with necrosis. Without respect to the presence of necrosis in granulomas, the majority of the patients (79%) had sarcoidosis or tuberculosis; 94% of the patients with sarcoidosis had non-necrotizing epithelioid cell granulomas and the remaining 6% had granulomas with necrosis. The sensitivity of non-necrotizing epithelioid cell granuloma for the diagnosis of sarcoidosis was 94% and specificity 60%. The positive and negative predictive values were 68% and 92%, respectively. Of the patients with tuberculosis 76% had epithelioid cell granulomas with necrosis and 24% had non-necrotizing epithelioid cell granulomas. The sensitivity of epithelioid cell granuloma with necrosis for the diagnosis of tuberculosis was 76% and specificity 85%. The positive and negative predictive values were 69%, and 88%, respectively. CONCLUSION: A significant overlap in types of granulomatous inflammation between tuberculosis and sarcoidosis was found. The type of epithelioid cell granuloma alone was not sufficient for the final clinical diagnosis. (+info)
Giant cell formation in sarcoidosis: cell fusion or proliferation with non-division?
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Pineal germinoma with a prominent epithelioid cell granuloma component: case report.
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A 20-year-old man presented with a rare case of germinoma with a large component of epithelioid cell granuloma manifesting as oscillopsia. Magnetic resonance imaging demonstrated a mass in the pineal region with homogeneous enhancement with gadolinium. Craniotomy was performed, ending in biopsy. The initial histological diagnosis was epithelioid cell granuloma, but systemic investigation detected no evidence of granulomatous disorder. A revised diagnosis of germinoma was based on positive immunohistochemical staining for placental alkaline phosphatase (PLAP) and c-kit. Histological diagnosis is sometimes incorrect if granulomatous reaction is dominant. Immunohistochemical staining for PLAP and c-kit should be performed if germinoma is clinically suspected. (+info)
Epithelioid cells in mediastinal lymph nodes of cattle without cancer.
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Primary gastric lymphoma with florid granulomatous reaction.
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Epithelioid cell granulomas are more commonly seen in Hodgkin's disease and T cell lymphomas. Rarely florid granulomatous reaction with necrosis may be a prominent feature in lymphoma. To the best of our knowledge, a total of 11 cases of Burkitt's lymphoma with florid necrotizing granulomas have been reported in the English literature. None of these cases have previously had the stomach involved. Here we report a gastric Burkitt's lymphoma with florid granulomatous reaction diagnosed following a partial gastrectomy. The initial gastric biopsy showed granulomatous gastritis but the radiological and endoscopic appearance was that of a gastric stromal tumour. We conclude that in the presence of a mass lesion, the finding of epithelioid granulomas should warrant re-biopsy to establish an accurate diagnosis and exclude a concurrent malignant process. Hence, major surgery and postoperative complications can be avoided and appropriate treatment regimen can be initiated. (+info)