Stachybotrys chartarum, trichothecene mycotoxins, and damp building-related illness: new insights into a public health enigma. (33/71)

Damp building-related illnesses (DBRI) include a myriad of respiratory, immunologic, and neurologic symptoms that are sometimes etiologically linked to aberrant indoor growth of the toxic black mold, Stachybotrys chartarum. Although supportive evidence for such linkages is limited, there are exciting new findings about this enigmatic organism relative to its environmental dissemination, novel bioactive components, unique cellular targets, and molecular mechanisms of action which provide insight into the S. chartarum's potential to evoke allergic sensitization, inflammation, and cytotoxicity in the upper and lower respiratory tracts. Macrocyclic trichothecene mycotoxins, produced by one chemotype of this fungus, are potent translational inhibitors and stress kinase activators that appear to be a critical underlying cause for a number of adverse effects. Notably, these toxins form covalent protein adducts in vitro and in vivo and, furthermore, cause neurotoxicity and inflammation in the nose and brain of the mouse. A second S. chartarum chemotype has recently been shown to produce atranones-mycotoxins that can induce pulmonary inflammation. Other biologically active products of this fungus that might contribute to pathophysiologic effects include proteinases, hemolysins, beta-glucan, and spirocyclic drimanes. Solving the enigma of whether Stachybotrys inhalation indeed contributes to DBRI will require studies of the pathophysiologic effects of low dose chronic exposure to well-characterized, standardized preparations of S. chartarum spores and mycelial fragments, and, coexposures with other environmental cofactors. Such studies must be linked to improved assessments of human exposure to this fungus and its bioactive constituents in indoor air using both state-of-the-art sampling/analytical methods and relevant biomarkers.  (+info)

Does short-term exposure to mobile phone base station signals increase symptoms in individuals who report sensitivity to electromagnetic fields? A double-blind randomized provocation study. (34/71)

BACKGROUND: Individuals with idiopathic environmental illness with attribution to electromagnetic fields (IEI-EMF) believe they suffer negative health effects when exposed to electromagnetic fields from everyday objects such as mobile phone base stations. OBJECTIVES: This study used both open provocation and double-blind tests to determine if sensitive and control individuals experience more negative health effects when exposed to base station-like signals compared with sham. METHODS: Fifty-six self-reported sensitive and 120 control participants were tested in an open provocation test. Of these, 12 sensitive and 6 controls withdrew after the first session. The remainder completed a series of double-blind tests. Subjective measures of well-being and symptoms as well as physiological measures of blood volume pulse, heart rate, and skin conductance were obtained. RESULTS: During the open provocation, sensitive individuals reported lower levels of well-being in both the global system for mobile communication (GSM) and universal mobile telecommunications system (UMTS) compared with sham exposure, whereas controls reported more symptoms during the UMTS exposure. During double-blind tests the GSM signal did not have any effect on either group. Sensitive participants did report elevated levels of arousal during the UMTS condition, whereas the number or severity of symptoms experienced did not increase. Physiological measures did not differ across the three exposure conditions for either group. CONCLUSIONS: Short-term exposure to a typical GSM base station-like signal did not affect well-being or physiological functions in sensitive or control individuals. Sensitive individuals reported elevated levels of arousal when exposed to a UMTS signal. Further analysis, however, indicated that this difference was likely to be due to the effect of order of exposure rather than the exposure itself.  (+info)

Living with toxic poisioning. (35/71)

In 1991 I was working as an administration officer at a school in North Queensland. I worked with two other women in a very small office and there were three other offices nearby, each with one person in them. The education department decided to put down new flooring around these offices, down the adjoining stairway and along the adjoining hallway. The new flooring was made up of coloured chips spread over the floor coated by a two part resin. At the time the flooring was being laid, the weather was very wet and humid. The two part coating would not set. It was soft to touch and smelt toxic. After complaints from office staff to the education department, the floor was patched up. This process happened about three times over a 3 year period.  (+info)

Measuring secondhand smoke exposure in children: an ecological measurement approach. (36/71)

OBJECTIVE: Behavioral, environmental, and biological measures of secondhand smoke (SHS) exposure are reviewed with special consideration of medically at-risk children. METHODS: An ecological measurement framework is introduced to examine SHS exposure of children in the context of their physical and social environments. RESULTS: The proposed approach emphasizes the need to measure (a) who uses tobacco, (b) where and when exposure takes place, (c) what media are contaminated, (d) how exposure takes place, (e) how much a child was exposed, and (f) factors that contribute to why tobacco is used in a child's environment. CONCLUSIONS: Existing research suggests that medically at-risk children are among the most vulnerable populations for the harmful effects of SHS exposure. Yet, little is currently known about how SHS exposure affects these populations. The proposed approach provides a framework for the comprehensive assessment of SHS exposure to study its health effects and to design effective interventions.  (+info)

The toxicity of diesel exhaust: implications for primary care. (37/71)

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Environmental factors as disease accelerators during chronic hepatitis C. (38/71)

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Clinical observation of 12 farmers who believe themselves to have suffered from chronic pesticide intoxication. (39/71)

BACKGROUND/AIM: We assessed twelve cases of suspected chronic pesticide intoxication, with medically unexplained physical symptoms. METHODS: Complete blood cell count (CBC), blood chemistry, routine urinalysis, chest X-ray, ECG, gastrofiberscopy, abdominal ultrasonography, neuroselective sensory nerve conduction threshold, and psychological assessment were performed on 12 farmers who believe themselves to have suffered from chronic pesticide intoxication. RESULTS: No specific abnormalities were observed on CBC, routine urinalysis, chest X-ray, ECG, gastroscopy, abdominal ultrasonography, or peripheral nerve conduction velocity test. They persistently manifested helplessness, depression, and anxiety. The results of both psychological assessment and general physical examination revealed the following clinical features: depression (8 cases), multiple chemical hypersensitivity syndrome (2 cases), alcoholism (1 case), and religious preoccupation (1 case). CONCLUSION: In those living in the western rural area of South Korea, depression is a prominent ongoing presentation in pesticide-exposed farmers, in addition to unexplainable physical symptoms.  (+info)

Air pollution threatens the health of children in China. (40/71)

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