Embryo LossGenes, LethalFetal DeathGene TargetingEmbryo, MammalianEmbryonic DevelopmentMice, KnockoutHomozygoteGene Expression Regulation, DevelopmentalHeterozygoteEmbryonic and Fetal DevelopmentMice, Mutant StrainsBlastocystPhenotypeMutationMice, TransgenicMice, Inbred C57BLGene DeletionIntegrasesCrosses, GeneticAllelesPregnancyNuclear ProteinsEmbryonic Stem CellsGenotypeApoptosisMesodermTranscription FactorsDNA-Binding ProteinsTumor Suppressor ProteinsCarrier ProteinsBase SequenceIn Situ HybridizationExonsSignal TransductionFibroblastsCell Cycle ProteinsStem CellsCell ProliferationMolecular Sequence DataCells, CulturedRNA, MessengerCell LineCell DifferentiationMammalsReverse Transcriptase Polymerase Chain ReactionTumor Suppressor Protein p53Cell SurvivalAmino Acid SequenceTime FactorsCardiovascular AbnormalitiesCell DivisionEmbryo, NonmammalianCaenorhabditis elegans ProteinsYolk SacNeural Tube DefectsCaenorhabditis elegansSequence Homology, Amino AcidAnimals, Genetically ModifiedDNA PrimersPlacentaChimeraMembrane ProteinsRNA InterferenceTransgenesBlood VesselsGene Knockout TechniquesMutagenesisFetal ViabilityHeartRecombination, GeneticMorphogenesisProtein-Serine-Threonine KinasesGene ExpressionDrosophilaGene Expression RegulationProteinsDrosophila melanogasterNervous SystemOrgan SpecificityPlacentationCloning, MolecularModels, GeneticOrganogenesisBlotting, WesternGenes, HelminthCell CycleLiverFetal HeartRepressor ProteinsProtein BindingProtein Structure, TertiaryDNA, ComplementaryImmunohistochemistryDNA DamageDNAChromosomes, MammalianMice, 129 StrainHomeodomain ProteinsTranscription, Genetic