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Cyclin D1Cyclin ACyclin ECyclin BCyclin B1Cyclin D2Cyclin D3Cyclin A1Cyclin A2Cyclin DCyclin G1Cyclin GCyclinsCyclin CCyclin-Dependent KinasesCyclin B2Cyclin TCyclin-Dependent Kinase 2Cyclin G2Cyclin HCell CycleCyclin-Dependent Kinase 4CDC2-CDC28 KinasesCDC2 Protein KinaseG1 PhaseCell Cycle ProteinsCyclin-Dependent Kinase Inhibitor p27S PhaseRetinoblastoma ProteinCyclin IMitosisOncogene ProteinsGenes, bcl-1Protein-Serine-Threonine KinasesCyclin-Dependent Kinase 6PhosphorylationCyclin-Dependent Kinase Inhibitor p21Cell DivisionG2 PhaseCell ProliferationTumor Suppressor ProteinsCell Line, TumorRNA, MessengerE2F Transcription Factorscdc25 PhosphatasesMolecular Sequence DataProto-Oncogene ProteinsCell NucleusTumor Cells, CulturedMicrotubule-Associated ProteinsGene Expression Regulation, NeoplasticProliferating Cell Nuclear AntigenF-Box ProteinsProtamine KinaseG0 PhaseCell LineProtein BindingBlotting, WesternMaturation-Promoting FactorDown-RegulationImmunohistochemistryTranscription FactorsTransfectionPromoter Regions, GeneticCyclin-Dependent Kinase Inhibitor p16Nuclear ProteinsGene Expression RegulationTranscription Factor DP1ApoptosisCyclin-Dependent Kinase 9HeLa CellsStarfishSignal Transduction3T3 CellsRetinoblastoma-Binding Protein 1Tumor Suppressor Protein p53Transcription, GeneticE2F1 Transcription FactorDNA-Binding ProteinsRetinoblastoma-Like Protein p107Amino Acid SequenceBase SequenceCells, CulturedProtein KinasesUbiquitin-Protein Ligase ComplexesMutationRecombinant Fusion ProteinsCDC28 Protein Kinase, S cerevisiaeS-Phase Kinase-Associated ProteinsEnzyme ActivationCyclin-Dependent Kinase Inhibitor ProteinsRNA, Small InterferingBreast NeoplasmsEnzyme InhibitorsOocytesLymphoma, Mantle-CellKi-67 AntigenNIH 3T3 CellsFibroblastsReverse Transcriptase Polymerase Chain Reaction

Combination of nutlin-3 and VX-680 selectively targets p53 mutant cells with reversible effects on cells expressing wild-type p53. (49/89)

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Quantitative reconstitution of mitotic CDK1 activation in somatic cell extracts. (50/89)

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BZL101, a phytochemical extract from the Scutellaria barbata plant, disrupts proliferation of human breast and prostate cancer cells through distinct mechanisms dependent on the cancer cell phenotype. (51/89)

BZL101 is an aqueous extract from the Scutellaria barbata plant shown to have anticancer properties in a variety of human cancers. In order to determine its efficacy on human reproductive cancers, we assessed the responses of two human breast cancer cell lines, estrogen sensitive MCF7 and estrogen insensitive MDA-MB-231, and of two human prostate cancer cell lines, androgen sensitive LNCaP and androgen insensitive PC3 which are human cell lines that represent early and late stage reproductive cancers. BZL101 inhibited reproductive cancer growth in all cell lines by regulating expression levels of key cell cycle components that differ with respect to the cancer cell phenotypes. In early stage estrogen sensitive MCF7 cells, BZL101 induced a G(1) cell cycle arrest and ablated expression of key G(1) cell cycle regulators Cyclin D1, CDK2 and CDK4, as well as growth factor stimulatory pathways and estrogen receptor-alpha expression. Transfection of luciferase reporter plasmids revealed that the loss of CDK2, CDK4 and estrogen receptor-alpha transcript expression resulted from the BZL-dependent ablation of promoter activities. BZL101 growth arrests early stage androgen sensitive LNCaP cells in the G(2)/M phase with corresponding decreases in Cyclin B1, CDK1 and androgen receptor expression. In late stage hormone insensitive breast (MDA-MB-231) and prostate (PC3) cancer cells, BZL101 induced an S phase arrest with corresponding ablations in Cyclin A2 and CDK2 expression. Our results demonstrate that BZL101 exerts phenotype specific anti-proliferative gene expression responses in human breast and prostate cancer cells, which will be valuable in the potential development of BZL-based therapeutic strategies for human reproductive cancers.  (+info)

BrunoL1 regulates endoderm proliferation through translational enhancement of cyclin A2 mRNA. (52/89)

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The roles of cyclin A2, B1, and B2 in early and late mitotic events. (53/89)

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Suppression of cell-cycle progression by Jun dimerization protein-2 (JDP2) involves downregulation of cyclin-A2. (54/89)

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Geminin escapes degradation in G1 of mouse pluripotent cells and mediates the expression of Oct4, Sox2, and Nanog. (55/89)

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Function of the A-type cyclins during gametogenesis and early embryogenesis. (56/89)

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