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Cyclic AMP-Dependent Protein Kinase Catalytic SubunitsCyclic AMPProtein KinasesProtein Kinase CCyclic AMP-Dependent Protein KinasesPhosphorylationCalcium-Calmodulin-Dependent Protein KinasesEnzyme ActivationProtein Kinase InhibitorsMolecular Sequence DataProtein-Serine-Threonine KinasesCalcium-Calmodulin-Dependent Protein Kinase Type 2Amino Acid SequenceCalcium-Calmodulin-Dependent Protein Kinase Type 1CalciumSignal TransductionCyclic GMP-Dependent Protein KinasesProtein SubunitsKineticsIsoenzymesCatalytic DomainCalmodulinCell LinePhosphatidylinositol 3-KinasesPhosphoprotein PhosphatasesMitogen-Activated Protein KinasesProtein BindingCells, CulturedParamecium tetraureliaMAP Kinase Signaling SystemEnzyme InhibitorsSubstrate SpecificityCyclic AMP-Dependent Protein Kinase Type IIp38 Mitogen-Activated Protein KinasesBase SequenceMutationeIF-2 KinaseCasein Kinase IICyclic GMPBinding SitesTetradecanoylphorbol AcetateProtein Kinase C-alphaCattleMitogen-Activated Protein Kinase 1Blotting, WesternAdenosine TriphosphateMacromolecular SubstancesCyclic AMP-Dependent Protein Kinase RIalpha SubunitProtamine KinaseSequence Homology, Amino AcidTransfectionMitogen-Activated Protein Kinase KinasesNucleotides, CyclicElectrophoresis, Polyacrylamide GelRecombinant ProteinsMitogen-Activated Protein Kinase 3AMP-Activated Protein KinasesMolecular WeightProtein Kinase C-deltaColforsinRNA, MessengerBucladesineCalcium-Binding ProteinsCloning, MolecularRecombinant Fusion ProteinsIsoquinolinesJNK Mitogen-Activated Protein KinasesPeptide TPhosphoproteinsRabbitsSerineCyclic GMP-Dependent Protein Kinase Type I1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine8-Bromo Cyclic Adenosine MonophosphateGene Expression Regulation, EnzymologicReceptors, Cyclic AMPProtein Phosphatase 1Carrier ProteinsProtein Structure, TertiaryCatalysis

PKA and PDE4D3 anchoring to AKAP9 provides distinct regulation of cAMP signals at the centrosome. (57/64)

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The activation loop of PKA catalytic isoforms is differentially phosphorylated by Pkh protein kinases in Saccharomyces cerevisiae. (58/64)

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Specific protein kinase C isoforms alpha and betaI are involved in follicle-stimulating hormone-induced mouse follicle-enclosed oocytes meiotic resumption. (59/64)

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STAT1, STAT6 and adenosine 3',5'-cyclic monophosphate (cAMP) signaling drive SOCS3 expression in inactive ulcerative colitis. (60/64)

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NPY Y1 receptors differentially modulate GABAA and NMDA receptors via divergent signal-transduction pathways to reduce excitability of amygdala neurons. (61/64)

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cAMP/PKA signaling defects in tumors: genetics and tissue-specific pluripotential cell-derived lesions in human and mouse. (62/64)

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Evolutionary paths of the cAMP-dependent protein kinase (PKA) catalytic subunits. (63/64)

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Association between PKA gene polymorphism and NTDs in high risk Chinese population in Shanxi. (64/64)

OBJECTIVE: This study aimed to investigate the single nucleotide polymorphisms (SNPs) of PKA and neural tube defects (NTDs) in Chinese population. METHOD: A total of 183 NTDs cases and 200 healthy controls were used in this study. 7 selected single nucleotide polymorphism (SNP) sites in the PKA gene were analyzed with MassArray high-throughput DNA analyzer with matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry. A series of statistical methods were carried out to investigate the correlation between the SNPs and the patient susceptibility to NTDs. RESULTS: Statistical analysis showed a significant correlation between the SNP sites rs12132032 in PRKACB and NTDs. The AA genotype, A-allele and dominant AA in rs12132032 significantly increased the incidence of NTDs especially anencephaly (OR=3.87, 95% CI: 1.80-8.34 with genotype; OR=2.08, 95% CI: 1.43-3.04 with allele; OR=3.10, 95% CI: 1.53-6.26 with dominant). The T-allele of rs594631 in PRKACB was correlative with NTDs in male but not in female. CONCLUSIONS: The gene polymorphism loci rs12132032 in PRKACB maybe a potential risk factor for anencephaly in Chinese population from Shanxi, while gender susceptibility may influence the correlation.  (+info)