Hedgehog signaling is a principal inducer of Myosin-II-driven cell ingression in Drosophila epithelia. (9/111)

Cell constriction promotes epithelial sheet invagination during embryogenesis across phyla. However, how this cell response is linked to global patterning information during organogenesis remains unclear. To address this issue, we have used the Drosophila eye and studied the formation of the morphogenetic furrow (MF), which is characterized by cells undergoing a synchronous apical constriction and apicobasal contraction. We show that this cell response relies on microtubules and F-actin enrichment within the apical domain of the constricting cell as well as on the activation of nonmuscle myosin. In the MF, Hedgehog (Hh) signaling is required to promote cell constriction downstream of cubitus interruptus (ci), and, in this context, Ci155 functions redundantly with mad, the main effector of dpp/BMP signaling. Furthermore, ectopically activating Hh signaling in fly epithelia reveals a direct relationship between the duration of exposure to this signaling pathway, the accumulation of activated Myosin II, and the degree of tissue invagination.  (+info)

Drosophila ELMO/CED-12 interacts with Myoblast city to direct myoblast fusion and ommatidial organization. (10/111)

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The YPWM motif links Antennapedia to the basal transcriptional machinery. (11/111)

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Septate junctions are required for ommatidial integrity and blood-eye barrier function in Drosophila. (12/111)

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Reconstructing the ancestral butterfly eye: focus on the opsins. (13/111)

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Hedgehog and Dpp signaling induce cadherin Cad86C expression in the morphogenetic furrow during Drosophila eye development. (14/111)

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Light and peptidergic eclosion hormone neurons stimulate a rapid eclosion response that masks circadian emergence in Drosophila. (15/111)

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Cell-type-specific transcription of prospero is controlled by combinatorial signaling in the Drosophila eye. (16/111)

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