Relapsing-remitting behavioural variant of frontotemporal dementia in a bipolar patient.
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We report the case of a bipolar I patient who was diagnosed with frontotemporal dementia at the age of 54 during a manic episode. Her neurological state improved when this episode ended. Each subsequent thymic relapse was associated with cognitive de fi cits which subsided when the patient became euthymic, even though SPECT continued to show the same frontal hypoperfusion. We here discuss the hypothesis that the cognitive reserve of this patient, a former journalist, may, except during her mood episodes, have provided her with suf fi cient resources to meet her life demands despite her underlying neurological disorder. (+info)
Cognitive reserve moderates the association between hippocampal volume and episodic memory in middle age.
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