Modular synthesis of polyphenolic benzofurans, and application in the total synthesis of malibatol a and shoreaphenol.
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Syntheses of click PEG-dexamethasone conjugates for the treatment of rheumatoid arthritis.
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Labeling live cells by copper-catalyzed alkyne--azide click chemistry.
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Convenient synthesis of a propargylated cyclic (3'-5') diguanylic acid and its "click" conjugation to a biotinylated azide.
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Azido-coronatine: a useful platform for "click chemistry"-mediated probe synthesis for bioorganic studies.
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We report on the development of azide-coronatine as a useful platform for azide alkyne cycloaddition ("click chemistry")-mediated synthesis of molecular probes. (+)-Azido-coronatine was synthesized in 10 steps with 11% yield using improved synthesis of coronafacic acid, in which the highly exo-selective Diels-Alder reaction (endo:exo > 1:25) is the key step. Azido coronatine was as effective as the original coronatine in a stomatal opening assay, and was easily modified to a fluorescein isothiocyanate (FITC)-labeled probe with high yield. (+info)
Double click reaction for the acquisition of a highly potent and selective mPTPB inhibitor.
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Triostin A derived hybrid for simultaneous DNA binding and metal coordination.
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Receptor agonists of macrophage migration inhibitory factor.
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