Subretinal and disc neovascularisation in serpiginous choroiditis.
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Three out of 15 patients with serpiginous choroiditis who have been followed up for 1 to 10 years (mean 4.9 years) developed subretinal neovascularisation in the macula. In one eye new vessels were treated with argon laser without attaining permanent obliteration, in the second eye the neovascular membrane was regarded as untreatable because it was under the fovea, and in the third eye new vessels became obliterated spontaneously after atrophy of the surrounding choriocapillaris and the pigment epithelium of the retina. In a furth patient disc new vessels were seen at the active stage of serpiginous choroiditis; these new vessels disappeared after scarring of the initial chorioretinal lesions. (+info)
Bilateral nodular sarcoid choroiditis with vitreous haemorrhage.
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A 21-year-old black man with presumed systemic sarcoidosis had bilateral choroidal nodules, unilateral retinal neovascularisation and vitreous haemorrhage, and non-caseating granulomas on percutaneous liver biopsy. The choroidal nodules were serially documented by fundus photography and fluorescein angiography over a 22-month period. Fluorescein angiography was more accurate than ophthalmoscopy in demonstrating choroidal inflammation. The choroidal nodules resolved after systemic corticosteroid therapy. A vitreous haemorrhage occurred probably secondary to neovascularisation related to occlusion of an inferotemporal branch vein. The non-resolving vitreous haemorrhage and associated traction retinal detachment were treated with vitrectomy and membrane sectioning. (+info)
Natural history of experimental histoplasmic choroiditis in the primate. I. Clinical features.
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The clinical features of the long-term (3-year) natural history of experimental histoplasmic choroiditis in primates are documented in this report. The acute choroiditis resolved into four types of lesions: chorioretinal adhesions (atrophic scars) (2%); retinal pigment epithelial window defects (21%); subclinical lesions (19%); and "disappearing" lesions (58%). It was noted that the most obvious, acute lesions tend to disappear by clinical examination with long-term follow up. No subretinal neovascularization or spontaneous "reactivation" was observed. (+info)
Natural history of experimental histoplasmic choroiditis in the primate. II. Histopathologic features.
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The histopathologic features of experimental multifocal histoplasmic choroiditis in the primate are presented. Eyes were studied at various time periods from 30 days to 3 years after intracarotid injection with live Histoplasma capsulatum organisms. The acute lesions produced resolved into four distinct resolution patterns (chorioretinal scars, retinal pigment epithelial defects, subclinical lesions, and "disappearing" lesions) whose histopathologic features were studied. Organisms could not be demonstrated by culture or special stains in lesions present more than 6 weeks. A feature common to all eyes studied, including those whose lesions were clinically inactive or had clinically "disappeared," was the persistence of small foci of lymphocytes in the choroid. Damage to Bruch's membrane was observed in some specimens. (+info)
Septic choroiditis with serous detachment of the retina in dogs.
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The present study describes a model of multifocal septic choroiditis with serous retinal detachment after intracarotid injection of Staphylococcus aureus or Streptococcus faecalis. The fundus lesions occurred mainly in the tapetal area and, on ophthalmoscopic examination, were more extensive after S. aureus than after S. faecalis injection. On histopathologic examination there were microabscesses in the inner choroid and subretinal space, disrupting the outer retina but sparing the inner retina. (+info)
Pathologic mechanisms of multifocal choroiditis with retinal detachment after carotid injection of Streptococcus mutans and other bacteria in dogs.
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Multifocal choroiditis with overlying retinal detachment occurs after carotid injection of certain bacteria in dogs. The ocular lesions occur mainly in the tapetal area of the retina, correlate with microabscesses in the inner choroid and subretinal space, and occasionally occur in the inner retina and anterior uveal tract. The major pathophysiologic factor involved in the dog model of septic choroiditis appears to be embolization of the choriocapillairies by "live" bacteria, which clump and adhere well to tissues. In the dosages used, antibiotics did not prevent or alter the severity of the fundus lesions. (+info)
Septic choroiditis with serous retinal detachment in Streptococcus mutans-injected dogs.
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This report describes a dog model of multifocal choroiditis with serous retinal detachment after carotid injection of Streptococcus mutans. The fundus lesions occurred mainly in the tapetal area of the retina, and, on histopathologic examination, microabscesses in the choroid and subretinal space were observed. (+info)
Acquired retinochoroiditis in hamsters inoculated with ME 49 strain Toxoplasma.
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PURPOSE: These studies were undertaken to establish an animal model for use in studies of ocular toxoplasmosis. An animal model is needed to examine the development, progression, and resolution of ocular Toxoplasma infections and to study the effects on the disease of currently used and experimental therapies. METHODS: Cysts of the ME 49 strain of Toxoplasma gondii were injected intraperitoneally into each of 60 golden hamsters. The hamsters' eyes were examined before inoculation and at intervals after inoculation, and fundus photographs were taken. Histologic sections were analyzed and photographed to document the ocular effects of the infection. RESULTS: Retinochoroiditis was found in both eyes of all hamsters within 2 to 3 weeks of inoculation. The disease resolved spontaneously without treatment and was quiescent in most cases at 12 weeks after inoculation. The animals remained in good general health, and those tested had high antibody titers to Toxoplasma (1:256 to 1:32,000) at 6 months after the infection. The discovery of cysts and lesions in the retina confirmed the diagnosis. CONCLUSIONS: Although the lesions were not identical to those of human disease, this animal model of ocular toxoplasmosis offers several advantages: reproducibility, short incubation time, spontaneous resolution without treatment, consistent production of cysts, and ease of inoculation intraperitoneally without intraocular injection. (+info)