Factors influencing the response of Escherichia coli to antibiotics in conditions prevailing in the infected urinary bladder.
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The response of a sensitive strain of Escherichia coli to a variety of antibiotics was examined in an in vitro model which simulates the hydrokinetic features of the urinary bladder. Recovery of bacterial cultures from antibiotic effects was observed following exposure to bactericidal and bacteristatic antibiotics and no substantial difference was noted between the effectiveness of bacteristatic and bactericidal agents except that bacteristatic antibiotics were more influenced by alteration of the conditions of "diuresis" and "frequency of micturition". The response of dense bacterial populations to high concentrations of 3 beta-lactam antibiotics varied markedly under the different hydrokinetic conditions. Possible reasons for these variations are discussed. (+info)
PDZK1 regulates two intestinal solute carriers (Slc15a1 and Slc22a5) in mice.
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Synthesis and biological activity of novel 3-(2-propenyl)-cephalosporins. I.
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The synthesis, antibacterial activity and oral absorption of novel cephalosporins (3a-3d) having a 2-propenyl group at the C-3 position are described. Diphenylmethyl 7-amino-3-(2-propenyl)-3-cephem-4-carboxylate HCl (4) prepared from 7-aminocephalosporanic acid in 12 steps was acylated with various acid moieties to give cephems 3a-3d. The cephems 3a-3c showed similar antibacterial activities as cefixime. However, these cephems were not well absorbed orally. (+info)
IND-6, a highly divergent IND-type metallo-beta-lactamase from Chryseobacterium indologenes strain 597 isolated in Burkina Faso.
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