Cell AgingCyclin-Dependent Kinase Inhibitor p16TelomereFibroblastsTumor Suppressor Protein p53Aging, PrematureTelomere ShorteningCyclin-Dependent Kinase Inhibitor p21Telomerasebeta-GalactosidaseAgingDNA DamageCell ProliferationCells, CulturedRetinoblastoma ProteinCell Cycle CheckpointsCell CycleCell Line, TumorOxidative StressCell Transformation, NeoplasticTumor Suppressor Protein p14ARFSirtuin 1Signal TransductionTumor Suppressor ProteinsCell LineProgeriaLongevityTelomeric Repeat Binding Protein 2NeoplasmsNuclear ProteinsGenes, p16RNA, Small InterferingReactive Oxygen SpeciesDiploidyPhenotypeGene Expression RegulationRNA InterferenceHeterochromatinApoptosisDown-RegulationWerner SyndromeHydrogen PeroxideGene Knockdown TechniquesDNA-Binding ProteinsModels, Biologicalras ProteinsCell DivisionPlant LeavesRepressor ProteinsOxidantsOncogenesTranscription FactorsUp-RegulationForeskinNevus, PigmentedCell Cycle ProteinsGene SilencingMice, KnockoutBlotting, WesternHCT116 CellsGenes, rasTOR Serine-Threonine KinasesHistonesCyclin-Dependent Kinase Inhibitor p15Polycomb Repressive Complex 1MutationProto-Oncogene Proteins c-mycInhibitor of Differentiation Protein 1Cell Line, TransformedGene Expression Regulation, NeoplasticSirtuinsRadiationToyocamycinReverse Transcriptase Polymerase Chain ReactionJumonji Domain-Containing Histone DemethylasesTelomere HomeostasisGenomic InstabilityGenes, p53Cyclin-Dependent Kinase Inhibitor p27Isopropyl ThiogalactosideIntranuclear Inclusion BodiesMicroRNAsEmbryo, MammalianProtein-Serine-Threonine KinasesCell ShapeAntigens, NuclearEndothelial CellsMice, Inbred C57BLPromoter Regions, GeneticRNA, MessengerCyclin-Dependent Kinase 6Proto-Oncogene Proteins c-mdm2Transcription, GeneticTransfectionEpithelial CellsPapillomavirus E7 ProteinsBiological MarkersMelanocytesPhosphorylationEpigenesis, Genetic