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Cell CycleCell Cycle ProteinsCheckpoint Kinase 2Cell Cycle CheckpointsDNA DamageG2 PhaseGenes, cdcAtaxia Telangiectasia Mutated ProteinsProtein-Serine-Threonine KinasesS PhaseMitosisG2 Phase Cell Cycle CheckpointsG1 PhaseDNA RepairProtein KinasesTumor Suppressor Protein p53Tumor Suppressor ProteinsDNA-Binding ProteinsM Phase Cell Cycle CheckpointsAtaxia TelangiectasiaGamma Rayscdc25 PhosphatasesNuclear ProteinsRadiation, IonizingDNA ReplicationHydroxyureaCyclinsCyclin-Dependent Kinase Inhibitor p21PhosphorylationSpindle ApparatusCDC2 Protein KinaseCyclin BRadiation ToleranceCell DivisionApoptosisGenomic InstabilityG1 Phase Cell Cycle CheckpointsMutationSaccharomyces cerevisiae ProteinsSchizosaccharomycesCyclin B1S Phase Cell Cycle CheckpointsUltraviolet RaysNocodazoleCell Line, TumorSignal TransductionCell LineSchizosaccharomyces pombe ProteinsDNA Breaks, Double-StrandedSaccharomyces cerevisiaeHeLa CellsRetinoblastoma ProteinChromosomal InstabilityFibroblastsBRCA1 ProteinModels, BiologicalFlow CytometryCyclin-Dependent Kinase 2Fungal ProteinsHistonesMolecular Sequence DataGenes, p53KinetochoresTumor Cells, CulturedCell ProliferationCell NucleusDNACyclin EMimosineIntracellular Signaling Peptides and ProteinsMethyl MethanesulfonateDNA Repair EnzymesCell SurvivalCDC2-CDC28 KinasesCyclin-Dependent KinasesRNA, Small InterferingCells, CulturedCaffeineCyclin AAphidicolinAmino Acid SequenceProtein BindingNucleic Acid Synthesis InhibitorsPolyploidyCentrosomeCyclin-Dependent Kinase Inhibitor p27MetaphaseThioguanineDose-Response Relationship, RadiationBlastulaHCT116 CellsCyclin D1Antineoplastic AgentsTime FactorsExonucleasesCarrier ProteinsChromosome BreakageBase Sequence14-3-3 ProteinsChromatin

p53: guardian of ploidy. (57/1169)

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Cellular iron depletion and the mechanisms involved in the iron-dependent regulation of the growth arrest and DNA damage family of genes. (58/1169)

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Gamma-tubulin is required for bipolar spindle assembly and for proper kinetochore microtubule attachments during prometaphase I in Drosophila oocytes. (59/1169)

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Gadd45a and Gadd45g regulate neural development and exit from pluripotency in Xenopus. (60/1169)

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Resveratrol inhibits proliferation and survival of Epstein Barr virus-infected Burkitt's lymphoma cells depending on viral latency program. (61/1169)

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Pre-B cell receptor-mediated activation of BCL6 induces pre-B cell quiescence through transcriptional repression of MYC. (62/1169)

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RNA interference-mediated survivin gene knockdown induces growth arrest and reduced migration of vascular smooth muscle cells. (63/1169)

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Synergistic growth inhibition of cancer cells harboring the RET/PTC1 oncogene by staurosporine and rotenone involves enhanced cell death. (64/1169)

TPC-1 is a highly proliferative thyroid papillary carcinoma-derived cell line. These cells express the RET/PTC1 fusion protein, whose isoforms are characterized in this work. The bacterial alkaloid staurosporine and the plant extract rotenone are death-inducing drugs that have an inhibitory synergistic effect on the growth of TPC-1 cells. We show that this synergism is accompanied by an enhancement of the induction of cell death. Staurosporine alone induces cell cycle arrest in G(1), whereas rotenone induces arrest in G(2)/M. We suggest that this additive pressure may drive cells to die, resulting in the synergistic interaction of the drug combination. These data emphasize the potential use of the staurosporine plus rotenone combination as an anticancer tool.  (+info)