AnatomyOrganismsDiseasesChemicals and DrugsPhenomena and Processes
CCN Intercellular Signaling ProteinsNephroblastoma Overexpressed ProteinCysteine-Rich Protein 61Connective Tissue Growth FactorImmediate-Early ProteinsIntercellular Signaling Peptides and ProteinsIntegrin alpha6beta1Fibromatosis, GingivalIntegrin alpha5beta1Integrin alphaVbeta3Cell AdhesionConnective Tissue CellsTransforming Growth Factor betaFibrosisFibroblastsInsulin-Like Growth Factor Binding ProteinsSignal TransductionCell MovementGrowth and DevelopmentEar CartilageMurinaeMesangial CellsGene Expression RegulationCells, CulturedNeovascularization, PhysiologicSmad3 ProteinCell ProliferationChondrocytes

Interleukin-18/WNT1-inducible signaling pathway protein-1 signaling mediates human saphenous vein smooth muscle cell proliferation. (65/98)

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Angiotensin-II type 1 receptor and NOX2 mediate TCF/LEF and CREB dependent WISP1 induction and cardiomyocyte hypertrophy. (66/98)

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Mechanical stretch induces epithelial-mesenchymal transition in alveolar epithelia via hyaluronan activation of innate immunity. (67/98)

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CCN6 (WISP3) decreases ZEB1-mediated EMT and invasion by attenuation of IGF-1 receptor signaling in breast cancer. (68/98)

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Kallikrein-related peptidase 12 hydrolyzes matricellular proteins of the CCN family and modifies interactions of CCN1 and CCN5 with growth factors. (69/98)

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Discovery of nonsteroidal anti-inflammatory drug and anticancer drug enhancing reprogramming and induced pluripotent stem cell generation. (70/98)

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CCN6 as a profibrotic mediator that stimulates the proliferation of lung fibroblasts via the integrin beta1/focal adhesion kinase pathway. (71/98)

Idiopathic pulmonary fibrosis is a progressive and lethal disease of the lung that is characterized by the proliferation of fibroblasts and increased deposition of the extracellular matrix. The CCN6/WISP-3 is a member of the CCN family of matricellular proteins, which consists of six members that are involved in many vital biological functions. However, the regulation of lung fibroblasts mediated by CCN6 protein has not been fully elucidated. Here, we demonstrated that CCN6 induced the proliferation of lung fibroblasts by binding to integrin beta1, leading to the phosphorylation of FAK(Y397). Furthermore, CCN6 showed a weak, but significant, ability to stimulate the expression of fibronectin. CCN6 was highly expressed in the lung tissues of mice treated with bleomycin. Our results suggest that CCN6 plays a role in the fibrogenesis of the lungs mainly by stimulating the growth of lung fibroblasts and is a potential target for the treatment of pulmonary fibrosis.  (+info)

Cysteine-rich 61-connective tissue growth factor-nephroblastoma-overexpressed 5 (CCN5)/Wnt-1-induced signaling protein-2 (WISP-2) regulates microRNA-10b via hypoxia-inducible factor-1alpha-TWIST signaling networks in human breast cancer cells. (72/98)

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