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Receptors, CalcitoninCalcitoninReceptors, Islet Amyloid PolypeptideCalcitonin Gene-Related PeptideReceptor Activity-Modifying ProteinsReceptor Activity-Modifying Protein 1Receptors, Calcitonin Gene-Related PeptideCalcitonin Receptor-Like ProteinReceptor Activity-Modifying Protein 3SalmonOsteoclastsReceptor Activity-Modifying Protein 2Islet Amyloid PolypeptideMolecular Sequence DataCyclic AMPAmino Acid SequenceReceptors, PeptideAcid PhosphataseCOS CellsBone ResorptionRANK LigandSequence Homology, Amino AcidAmyloidIntracellular Signaling Peptides and ProteinsCercopithecus aethiopsCloning, MolecularCell LineReceptors, Cell SurfaceBase SequenceMembrane ProteinsPeptidesReceptor Activator of Nuclear Factor-kappa BBinding, CompetitiveTransfectionRNA, MessengerProtein BindingCells, CulturedAdenylate Cyclase Toxin

Age-related changes in dorsal root ganglia, circulating and vascular calcitonin gene-related peptide (CGRP) concentrations in female rats: effect of female sex steroid hormones. (73/119)

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Molecular basis of association of receptor activity-modifying protein 3 with the family B G protein-coupled secretin receptor. (74/119)

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Investigation of the association between CALCRL polymorphisms and primary angle closure glaucoma. (75/119)

PURPOSE: To determine whether the polymorphisms of calcitonin receptor-like receptor gene (CALCRL) are associated with primary angle closure glaucoma (PACG) in a southern Chinese population. METHODS: A total of 207 individuals with acute and chronic PACG and 205 ethnically matched controls were recruited in the current study. A tag-single nucleotide polymorphism approach was used to investigate this gene. Alleles were determined by PCR restriction fragment length polymorphism. RESULTS: The results show a nominal association between rs1157699 and acute PACG (uncorrected p=0.024 and 0.028 for alleles and genotypes, respectively). Haplotype T(rs840617)C(rs6759535)T(rs1157699) frequency is significantly higher in acute PACG patients than in controls (corrected p=0.012), whereas haplotype T(rs840617)C(rs6759535)C(rs1157699) frequency is significantly lower in acute PACG patients compared with controls (corrected p=0.02). However, no significant difference was detected between chronic PACG and CALCRL tag single nucleotide polymorphisms. CONCLUSIONS: The study suggests a possible role of CALCRL in the pathogenesis of acute PACG but not chronic PACG. A replication of this study with a larger sample size as well as on different populations will be helpful in confirming this finding.  (+info)

Activation of calcitonin receptor and calcitonin receptor-like receptor by membrane-anchored ligands. (76/119)

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Mapping interaction sites within the N-terminus of the calcitonin gene-related peptide receptor; the role of residues 23-60 of the calcitonin receptor-like receptor. (77/119)

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Non-peptidic antagonists of the CGRP receptor, BIBN4096BS and MK-0974, interact with the calcitonin receptor-like receptor via methionine-42 and RAMP1 via tryptophan-74. (78/119)

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Structure-function relationships of the N-terminus of receptor activity-modifying proteins. (79/119)

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Cystathionine gamma-lyase deficiency and overproliferation of smooth muscle cells. (80/119)

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