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(1/99) Keratinocyte growth factor protects against Clara cell injury induced by naphthalene.

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(2/99) Distal airways in mice exposed to cigarette smoke: Nrf2-regulated genes are increased in Clara cells.

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(3/99) A technological advance comparing epithelial lining fluid from different regions of the lung in smokers.

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(4/99) Prospective isolation of bronchiolar stem cells based upon immunophenotypic and autofluorescence characteristics.

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(5/99) A protein kinase Cdelta-dependent protein kinase D pathway modulates ERK1/2 and JNK1/2 phosphorylation and Bim-associated apoptosis by asbestos.

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(6/99) Drosophila convoluted/dALS is an essential gene required for tracheal tube morphogenesis and apical matrix organization.

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(7/99) Type IV collagen alpha chains of the basement membrane in the rat bronchioalveolar transitional segment.

In the present study, we have analyzed the alpha(IV) chain distribution in the subepithelial basement membrane (BM) of the rat pulmonary airway from the bronchi to alveoli. We have furthermore analyzed the alpha(IV) chain distribution in the subepithelial BM of the bronchioalveolar duct junction (BADJ) using alpha(IV) chain specific monoclonal antibodies. Our results show that the BM of the bronchial and bronchiolar epithelium contains [alpha1(IV)]2alpha2(IV) and [alpha5(IV)]2alpha6(IV) molecules and confirmed that the alveolar BM consists of [alpha1(IV)]2alpha2(IV) and alpha3(IV) alpha4(IV)alpha5(IV) molecules. There are also small regions in BADJ consisting of only [alpha1(IV)]2alpha2(IV) molecules without alpha3(IV)alpha4(IV)alpha5(IV) and [alpha5(IV)]2alpha6(IV) molecules. Moreover, the bronchioalveolar stem cells (BASCs)-primordial cells for bronchiolar Clara cells and alveolar type II (AT2) cells - lie adjacent to such small regions. These findings suggest that [alpha1(IV)]2 alpha2(IV) may be important for the BASCs to self-renew or to self-maintain themselves and that microenvironments produced by alpha(IV) chains may be important for cell differentiation.  (+info)

(8/99) beta-Catenin is not necessary for maintenance or repair of the bronchiolar epithelium.

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