Functional impact of heterogeneous nuclear ribonucleoprotein A2/B1 in smooth muscle differentiation from stem cells and embryonic arteriogenesis.
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Pneumonectomy for congenital isolated unilateral pulmonary artery agenesis.
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Unilateral pulmonary artery agenesis (UPAA) is a rare congenital anomaly usually diagnosed in infancy due to associated cardiovascular malformations. We report a rare case of isolated right UPAA that presented atypically in adulthood with massive haemoptysis requiring a pneumonectomy. This case highlights the importance of maintaining a high clinical suspicion, the role of CT angiography and a multi disciplinary approach. Optimal management is often surgical however bronchial artery embolization (BAE) remains a useful adjunct. (+info)
64-detector row CT evaluation of bronchial and non-bronchial systemic arteries in life-threatening haemoptysis.
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Preoperative measurement of pulmonary vascular resistance in complete transposition of the great arteries.
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Transposition of the great arteries is frequently complicated by the early onset of pulmonary vascular disease. It is difficult to measure pulmonary blood flow by the Fick principle because the pulmonary arteriovenous oxygen content difference is small and bronchial blood flow is increased in this condition. In eight patients (mean age 7.7 years, range 3 months to 29 years) with transposition of the great arteries mass spectrometry was used to measure oxygen uptake and predict pulmonary end capillary blood oxygen content. The effects of the bronchial circulation were studied by computer modelling. There was close agreement between pulmonary end capillary and pulmonary vein blood oxygen contents but the resultant percentage difference in arteriovenous content difference was significant (mean (SE of difference)) (14.5(3.8)%). The effect of the bronchial circulation was to give spuriously high estimates of pulmonary blood flow. The error was greatest when oxygen consumption was low and aortic blood was very desaturated. (+info)
Differential effects of inhaled methacholine on circumferential wall and vascular smooth muscle of third-generation airways in awake sheep.
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Pulmonary shunting by the bronchial artery in the anaesthetized horse.
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In the quietly standing horse the bronchial arterial blood flow is low, 0.1-0.2% of the pulmonary arterial flow. In horses anaesthetized with halothane, the bronchial arterial flow is reduced by a greater fraction than that in the pulmonary artery. Thus the shunting through the bronchial circulation is decreased about 3-fold by anaesthesia, and cannot, therefore, contribute significantly to the increased alveolar-arterial gradient seen in dorsal recumbency. The results indicate bronchial vasoconstriction under anaesthesia. (+info)
Coronary to bronchial artery fistula: are we treating it right?
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Fistulas between coronary artery and bronchial artery may be present from birth, with few hemodynamic consequences, and may remain closed due to similarity of the filling pressures at these 2 sites. They can also be secondary to pulmonary artery occlusive disease or chronic pulmonary inflammation. These pulmonary changes may cause a dilation of the fistula and make it functional, causing angina pectoris by coronary steal syndrome, which is the most common symptom. The presentation may also be composed of episodes of hemoptysis, heart failure, and infective endocarditis. However, most patients remain asymptomatic. The ones that need treatment may not have a good response to the medical management, requiring an intervention. This can be done using embolization coils, stents grafts, and performing surgical ligation of the fistulas. (+info)