MAPK signaling in equations and embryos.
(49/246)The Extracellularly Regulated Kinase/Mitogen Activated Protein Kinase (ERK/MAPK) signaling pathway is a critical regulator of cellular processes in adult and developing tissues. Depending on the cellular context, MAPK cascade can act as a rheostat, a switch, or an oscillator. The highly conserved structure of the cascade does not imply a rigid function, as was suggested by the early mathematical models of MAPK signaling, and can instead produce a wide range of input-output maps. Given a large number of pathway components and modes of regulation, it is essential to establish experimental systems that will allow both manipulating the MAPK cascade and monitoring its dynamics. The terminal patterning system in the Drosophila embryo appears to be ideally suited for this purpose. Our recent experiments characterized dynamics of the MAPK phosphorylation gradient in the terminal system and proposed that it is regulated by a cascade of diffusion-trapping modules. Here we discuss a biophysical model that can describe the observed dynamics and guide future experiments for exploring the relative importance of multiple layers of MAPK cascade regulation. (+info)
Biophysical characterization of a new phospholipid analogue with a spin-labeled unsaturated fatty acyl chain.
Stability of protein-decorated mixed lipid membranes: The interplay of lipid-lipid, lipid-protein, and protein-protein interactions.
Excitability at the motoneuron pool and motor cortex is specifically modulated in lengthening compared to isometric contractions.
Responses of neurons in chinchilla auditory cortex to frequency-modulated tones.
Enhanced CREB-dependent gene expression increases the excitability of neurons in the basal amygdala and primes the consolidation of contextual and cued fear memory.
The effect of age on a visual learning task in the American cockroach.
Evidence that exocytosis is driven by calcium entry through multiple calcium channels in goldfish retinal bipolar cells.