Improved supersaturation and oral absorption of dutasteride by amorphous solid dispersions.
(65/97)
In this study, amorphous solid dispersions containing dutasteride and various excipients, manufactured by spray-drying processes, were characterized to determine the effects on their ability to form supersaturated solutions and to identify the effects of supersaturation on increasing the bioavailability of dutasteride. The excipients included Eudragit E, hydroxypropyl-beta-cyclodextrin (HP-beta-CD), hydroxypropyl cellulose (HPC), hydroxypropylmethyl cellulose (HPMC), and polyvinylpyrrolidone (PVP K30). A solid dispersion with Eudragit E displayed a high maximum supersaturation with extended supersaturation, compared with a water-soluble polymer. The maximum concentration and the degree of supersaturation increased in the following order: PVP K3024 h) and C(max) of dutasteride increased with supersaturation concentration. These results suggest that amorphous solid dispersions containing Eudragit E, formed by a spray-drying process, offer enhanced supersaturation characteristics, leading to increased oral absorption of dutasteride. (+info)
The G84E mutation of HOXB13 is associated with increased risk for prostate cancer: results from the REDUCE trial.
(66/97)
Effect of dutasteride on clinical progression of benign prostatic hyperplasia in asymptomatic men with enlarged prostate: a post hoc analysis of the REDUCE study.
(69/97)
Influence of hydrophilic additives on the supersaturation and bioavailability of dutasteride-loaded hydroxypropyl-beta-cyclodextrin nanostructures.
(71/97)
Prostate cancer cells differ in testosterone accumulation, dihydrotestosterone conversion, and androgen receptor signaling response to steroid 5alpha-reductase inhibitors.
(72/97)