Total synthesis and the biological activities of (+/-)-norannuradhapurine. (17/80)

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Total syntheses of telisatin A, telisatin B and lettowianthine. (18/80)

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Grandine A, a new proaporphine alkaloid from the bark of Phoebe grandis. (19/80)

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(+/-)-Nantenine analogs as antagonists at human 5-HT(2A) receptors: C1 and flexible congeners. (20/80)

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First total syntheses of (+/-)-isopiline, (+/-)-preocoteine, (+/-)-oureguattidine and (+/-)-3-methoxynordomesticine and the biological activities of (+/-)-3-methoxynordomesticine. (21/80)

A convenient and economical synthesis of 4-hydroxy-2,3-dimethoxybenzaldehyde has been developed. This was used as the starting material for the first total syntheses of (+/-)-isopiline, (+/-)-preocoteine, (+/-)-oureguattidine and (+/-)-3-methoxynordomesticine in which the key step involved formation of ring C of the aporphines by a radical-initiated cyclisation. Although (+/-)-3-methoxynordomesticine possesses weak antimicrobial activity, it inhibits the production of nitric oxide (NO), prostaglandin (PG)E(2), tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta and IL-6 and the expression of inducible nitric oxide synthase (iNOS) and cycloxygenase (COX)-2 in macrophages stimulated with LPS in vitro.  (+info)

(+)-N-(2-hydroxypropyl)lindcarpine: a new cytotoxic aporphine isolated from Actinodaphne pruinosa Nees. (22/80)

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The aporphine alkaloid boldine induces adiponectin expression and regulation in 3T3-L1 cells. (23/80)

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Bioactive constituents of the stem bark of Mitrephora glabra. (24/80)

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