Total synthesis and the biological activities of (+/-)-norannuradhapurine.
(17/80)
(+info)
Total syntheses of telisatin A, telisatin B and lettowianthine.
(18/80)
(+info)
Grandine A, a new proaporphine alkaloid from the bark of Phoebe grandis.
(19/80)
(+info)
(+/-)-Nantenine analogs as antagonists at human 5-HT(2A) receptors: C1 and flexible congeners.
(20/80)
(+info)
First total syntheses of (+/-)-isopiline, (+/-)-preocoteine, (+/-)-oureguattidine and (+/-)-3-methoxynordomesticine and the biological activities of (+/-)-3-methoxynordomesticine.
(21/80)
A convenient and economical synthesis of 4-hydroxy-2,3-dimethoxybenzaldehyde has been developed. This was used as the starting material for the first total syntheses of (+/-)-isopiline, (+/-)-preocoteine, (+/-)-oureguattidine and (+/-)-3-methoxynordomesticine in which the key step involved formation of ring C of the aporphines by a radical-initiated cyclisation. Although (+/-)-3-methoxynordomesticine possesses weak antimicrobial activity, it inhibits the production of nitric oxide (NO), prostaglandin (PG)E(2), tumor necrosis factor (TNF)-alpha, interleukin (IL)-1 beta and IL-6 and the expression of inducible nitric oxide synthase (iNOS) and cycloxygenase (COX)-2 in macrophages stimulated with LPS in vitro. (+info)
(+)-N-(2-hydroxypropyl)lindcarpine: a new cytotoxic aporphine isolated from Actinodaphne pruinosa Nees.
(22/80)
(+info)
The aporphine alkaloid boldine induces adiponectin expression and regulation in 3T3-L1 cells.
(23/80)
(+info)
Bioactive constituents of the stem bark of Mitrephora glabra.
(24/80)
(+info)