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Apocrine GlandsAnal SacsAnal Gland NeoplasmsSweat Gland NeoplasmsHidradenitis SuppurativaSweat Gland DiseasesPerianal GlandsPaget Disease, ExtramammaryDog DiseasesSalivary GlandsDogsMammary Glands, AnimalExocrine GlandsSubmandibular GlandParotid GlandEncyclopedias as TopicFibrocystic Breast DiseaseOsteitis DeformansPaget's Disease, MammaryMyositis, Inclusion BodyCarcinoma, Intraductal, NoninfiltratingMohs SurgeryNipples

Earwax, osmidrosis, and breast cancer: why does one SNP (538G>A) in the human ABC transporter ABCC11 gene determine earwax type? (41/80)

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Molecular characterization of apocrine carcinoma of the breast: validation of an apocrine protein signature in a well-defined cohort. (42/80)

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A functional ABCC11 allele is essential in the biochemical formation of human axillary odor. (43/80)

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Occurrence of apocrine secretion in the larval gut epithelial cells of Aedes aegypti L., Anopheles albitarsis Lynch-Arribalzaga and Culex quinquefasciatus say (Diptera: Culicidae): a defense strategy against infection by Bacillus sphaericus Neide? (44/80)

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Genetic influences on human body odor: from genes to the axillae. (45/80)

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Apocrine hidradenocarcinoma of the scalp: a classification conundrum. (46/80)

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Pharmacogenomics of human ABC transporter ABCC11 (MRP8): potential risk of breast cancer and chemotherapy failure. (47/80)

Some genetic polymorphisms of human ABC transporter genes are reportedly related to the risk of certain diseases and patients' responses to medication. Human ABCC11 functions as an ATP-dependent efflux pump for amphipathic anions. One non-synonymous SNP 538G>A (Gly180Arg) has been found to greatly affect the function and stability of de novo synthesized ABCC11 (Arg180) variant protein. The SNP variant lacking N-linked glycosylation is recognized as a misfolded protein in the endoplasmic reticulum (ER) and readily undergoes proteasomal degradation. This ER-associated degradation of ABCC11 protein underlies the molecular mechanism of affecting the function of apocrine glands. On the other hand, the wild type (Gly180) of ABCC11 is associated with wet-type earwax, axillary osmidrosis, colostrum secretion from the mammary gland, and the potential susceptibility of breast cancer. Furthermore, the wild type of ABCC11 reportedly has ability to efflux cyclic nucleotides and nucleoside-based anticancer drugs. The SNP (538G>A) of the ABCC11 gene is suggested to be a clinical biomarker for prediction of chemotherapeutic efficacy. Major obstacle to the successful chemotherapy of human cancer is development of resistance, and nucleoside-based chemotherapy is often characterized by inter-individual variability. This review provides an overview about the discovery and the genetic polymorphisms in human ABCC11. Furthermore we focus on the impact of ABCC11 538G>A on the apocrine phenotype, patients' response to nucleoside-based chemotherapy, and the potential risk of breast cancer.  (+info)

Androgen receptor driven transcription in molecular apocrine breast cancer is mediated by FoxA1. (48/80)

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