Small-molecule inhibitor which reactivates p53 in human T-cell leukemia virus type 1-transformed cells.
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Matrix-assisted laser desorption/ionization time-of-flight mass spectrometric analysis of cellular glycerophospholipids enabled by multiplexed solvent dependent analyte-matrix interactions.
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Isolation and characterization of a new mutant human cell line unresponsive to alpha and beta interferons.
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Previously we described human cell line 2fTGH, in which expression of guanine phosphoribosyltransferase is tightly controlled by the upstream region of interferon (IFN)-stimulated human gene 6-16. After mutagenesis of 2fTGH and selection with 6-thioguanine and IFN-alpha, we isolated 11.1, a recessive mutant that does not respond to IFN-alpha. We now describe U2, a second recessive mutant, selected similarly, that complements 11.1. U2 had no response to IFN-alpha or IFN-beta, and its response to IFN-gamma was partially defective. Although many genes did respond to IFN-gamma in U2, the 9-27 gene did not and the antiviral response of U2 cells to IFN-gamma was greatly reduced. Band shift assays showed that none of the transcription factors normally induced in 2fTGH cells by IFN-alpha (E and M) or IFN-gamma (G) were induced in U2. However, extracts of untreated U2 cells gave rise to a novel band that was increased by treatment with IFN-gamma but not IFN-alpha. Band shift complementation assays revealed that untreated and IFN-gamma-treated U2 cells lack the functional E gamma subunit of transcription factor E and that IFN-alpha-treated U2 cells do contain the functional E alpha subunit. (+info)
High-affinity triplex targeting of double stranded DNA using chemically modified peptide nucleic acid oligomers.
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On the role of topoisomerase I in mediating the cytotoxicity of 9-aminoacridine-based anticancer agents.
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9-Aminoacridine inhibition of HIV-1 Tat dependent transcription.
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Selective desorption/ionization of sulfatides by MALDI-MS facilitated using 9-aminoacridine as matrix.
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MALDI-TOF/MS analysis of archaebacterial lipids in lyophilized membranes dry-mixed with 9-aminoacridine.
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